Results 31 to 40 of about 1,344,829 (308)

Why Diversion Is Not Enough: A Comprehensive Community-Based Model for Juvenile Detention Alternatives, Diversion, and Restorative Services Programming

Social Sciences
Diversionary programs in the United States juvenile justice system were designed to redirect youth from formal legal processing towards services such as treatment, community service, or counseling. Alternative to Detention (ATD) emerged as a key strategy
Denise L. Jones, Dennis F. Jones, Zaida V. Pearson, Brittani Parham, Deanna C. E. Sinex, Lori Crawford, Keith Jamison   +6 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Spatial learning in pigs: effects of environmental enrichment and individual characteristics on behaviour and performance [PDF]

, 2008
Contains fulltext : 77372.pdf (Publisher’s version ) (Closed access)This study investigated the effects of both environmental enrichment and individual behavioural characteristics on spatial cognitive capabilities of pigs, using a novel
Jarno Jansen, J. Elizabeth Bolhuis, Schouten, W.G.P., Spruijt, B.M., Willem G. P. Schouten, Wiegant, V.M., Bolhuis, J.E., Berry M. Spruijt, Jansen, J., Victor M. Wiegant, Jarno JarnoJansen   +10 more
core   +1 more source

Release performance and kinetic behavior of volatile products from controlled pressure pyrolysis of oil shale in nitrogen atmosphere

Scientific Reports, 2023
The gas injection parameters such as temperature, pressure and duration during the in-situ pyrolysis of oil shale are important factors that affect the pore evolution and product release characteristics of oil shale. This paper takes Huadian oil shale as
Shuai Zhao, Jianzheng Su, Junwen Wu
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Home enrichment is associated with visual working memory function in preschoolers [PDF]

, 2023
Home enrichment plays an important role in shaping children's development. In the current study, we inquired whether home enrichment was associated with pre-schoolers' visual working memory (VWM) function, a critical cognitive system necessary for ...
Caes, Line, Wijeakumar, Sobanawartiny, Shing, Yee Lee, McKay, Courtney, Rafetseder, Eva, Davidson, Christina   +5 more
core   +1 more source

Volume fracturing of deep shale gas horizontal wells

Natural Gas Industry B, 2017
Deep shale gas reservoirs buried underground with depth being more than 3500 m are characterized by high in-situ stress, large horizontal stress difference, complex distribution of bedding and natural cracks, and strong rock plasticity.
Tingxue Jiang, Xiaobing Bian, Haitao Wang, Shuangming Li, Changgui Jia, Honglei Liu, Haicheng Sun   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In-situ stress prediction methods for continental shale oil reservoirs based on rheological models

Shiyou shiyan dizhi
Continental shale oil reservoirs typically exhibit strong heterogeneity, high clay content, and complex structural configurations, which result in significant deviations in conventional in-situ stress prediction methods.
Xinyu WANG, Xiwu LIU, Yuwei LIU, Qian LIU, Jiong LIU, Jinqiang ZHANG, Zizhuo MA, Yanjun XIAO   +7 more
doaj   +1 more source