Results 61 to 70 of about 14,747,636 (304)

Valutare la plusdotazione a scuola. Schoolwide Enrichment Model (SEM) per una didattica inclusiva dei gifted children

IUL Research
Nel grande capitolo dei Bisogni Educativi Speciali rientrano le alunne e gli alunni ad alto potenziale cognitivo (APC), meglio conosciuto, in ambito internazionale, con il termine anglosassone giftedness. La ricerca-formazione che sarà presentata in
Ilenia Amati
doaj   +1 more source

Quantification of histone modification ChIP-seq enrichment for data mining and machine learning applications

BMC Research Notes, 2011
Background The advent of ChIP-seq technology has made the investigation of epigenetic regulatory networks a computationally tractable problem. Several groups have applied statistical computing methods to ChIP-seq datasets to gain insight into the ...
Bekiranov Stefan, Xu Xiaojiang, Hoang Stephen A   +2 more
doaj   +1 more source

A probabilistic generative model for GO enrichment analysis [PDF]

Nucleic Acids Research, 2008
The Gene Ontology (GO) is extensively used to analyze all types of high-throughput experiments. However, researchers still face several challenges when using GO and other functional annotation databases. One problem is the large number of multiple hypotheses that are being tested for each study.
Lu, Yong, Rosenfeld, Roni, Simon, Itamar, Nau, Gerard J., Bar-Joseph, Ziv   +4 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

On the use of an internal DSL for enriching EMF models [PDF]

Proceedings of the 12th Workshop on OCL and Textual Modelling, 2012
The Object Constraint Language (OCL) is widely used to enrich modeling languages with structural constraints, side effect free query operations implementation and contracts. OCL was designed to be small and compact language with appealing short "to-the-point" expressions.
Filip Krikava, Philippe Collet
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Theoretical Investigation of the Material Usage During On-Bead Enrichment of Post-Translationally Modified Peptides in Suspension Systems

Molecules
Over the past decade, the number and diversity of identified protein post-translational modifications (PTMs) have grown significantly. However, most PTMs occur at relatively low abundance, making selective enrichment of modified peptides essential.
Kai Liu, Yuanyu Huang, Thomas Huang, Pengyuan Yang, Jilie Kong, Huali Shen, Quanqing Zhang   +6 more
doaj   +1 more source

Simulation analysis of the mechanism and influencing factors of remaining oil secondary enrichment in ultra-high water cut fault block reservoirs

Energy Exploration & Exploitation, 2023
After the near-abandoned production wells in the high part of the fault block reservoir are closed for a period of time, the remaining oil in the low part will accumulate at the fault in the high part to produce secondary enrichment. At present, research
Chuanzhi Cui, Jing Li, Zhongwei Wu, Ran Zong, Weijun Kong, Lifeng Li, Jianning Zhang, Shuzhen Su   +7 more
doaj   +1 more source

Semantically Enriched Models for Modal Sense Classification [PDF]

Proceedings of the First Workshop on Linking Computational Models of Lexical, Sentential and Discourse-level Semantics, 2015
Modal verbs have different interpretations depending on their context. Previous approaches to modal sense classification achieve relatively high performance using shallow lexical and syntactic features. In this work we uncover the difficulty of particular modal sense distinctions by eliminating both distributional bias and sparsity of existing small ...
Mengfei Zhou, Anette Frank, Annemarie Friedrich, Alexis Palmer   +3 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source