Results 51 to 60 of about 256,585 (269)

Optimasi Prakiraan Cuaca Menggunakan Metode Ensemble pada Naïve Bayes dan C4.5

JuTISI (Jurnal Teknik Informatika dan Sistem Informasi), 2022
Peramalan cuaca merupakan hal yang penting bagi keberlangsungan hidup masyarakat luas. Oleh karena itu, akurasi dari peramalan cuaca haruslah tinggi. Berdasarkan hal itu maka dilakukan penelitian untuk meningkatkan akurasi peramalan cuaca dengan model ...
Vini Indri Yani, Aradea Aradea, Husni Mubarok   +2 more
doaj   +1 more source

Ensembl 2007 [PDF]

Nucleic Acids Research, 2007
The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from Ensembl has increased from 15 to 33, with the addition of sites for the mammalian genomes of elephant, rabbit, armadillo, tenrec, platypus, pig, cat, bush baby ...
Hubbard, T. J. P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., Clarke, L., Coates, G., Cunningham, F., Cutts, T., Down, T., Dyer, S. C., Fitzgerald, S., Fernandez-Banet, J., Graf, S., Haider, S., Hammond, M., Herrero, J., Holland, R., Howe, K., Howe, K., Johnson, N., Kahari, A., Keefe, D., Kokocinski, F., Kulesha, E., Lawson, D., Longden, I., Melsopp, C., Megy, K., Meidl, P., Ouverdin, B., Parker, A., Prlic, A., Rice, S., Rios, D., Schuster, M., Sealy, I., Severin, J., Slater, G., Smedley, D., Spudich, G., Trevanion, S., Vilella, A., Vogel, J., White, S., Wood, M., Cox, T., Curwen, V., Durbin, R., Fernandez-Suarez, X. M., Flicek, P., Kasprzyk, A., Proctor, G., Searle, S., Smith, J., Ureta-Vidal, A., Birney, E.   +57 more
openaire   +4 more sources

Ensembl 2020

Nucleic Acids Research, 2019
Abstract The Ensembl (https://www.ensembl.org) is a system for generating and distributing genome annotation such as genes, variation, regulation and comparative genomics across the vertebrate subphylum and key model organisms. The Ensembl annotation pipeline is capable of integrating experimental and reference data from multiple ...
Andrew D Yates, Premanand Achuthan, Wasiu Akanni, James Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Andrey G Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, José Carlos Marugán, Carla Cummins, Claire Davidson, Kamalkumar Dodiya, Reham Fatima, Astrid Gall, Carlos Garcia Giron, Laurent Gil, Tiago Grego, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Mike Kay, Ilias Lavidas, Tuan Le, Diana Lemos, Jose Gonzalez Martinez, Thomas Maurel, Mark McDowall, Aoife McMahon, Shamika Mohanan, Benjamin Moore, Michael Nuhn, Denye N Oheh, Anne Parker, Andrew Parton, Mateus Patricio, Manoj Pandian Sakthivel, Ahamed Imran Abdul Salam, Bianca M Schmitt, Helen Schuilenburg, Dan Sheppard, Mira Sycheva, Marek Szuba, Kieron Taylor, Anja Thormann, Glen Threadgold, Alessandro Vullo, Brandon Walts, Andrea Winterbottom, Amonida Zadissa, Marc Chakiachvili, Bethany Flint, Adam Frankish, Sarah E Hunt, Garth IIsley, Myrto Kostadima, Nick Langridge, Jane E Loveland, Fergal J Martin, Joannella Morales, Jonathan M Mudge, Matthieu Muffato, Emily Perry, Magali Ruffier, Stephen J Trevanion, Fiona Cunningham, Kevin L Howe, Daniel R Zerbino, Paul Flicek   +75 more
openaire   +2 more sources

Ensembl 2018 [PDF]

Nucleic Acids Research, 2017
The Ensembl project has been aggregating, processing, integrating and redistributing genomic datasets since the initial releases of the draft human genome, with the aim of accelerating genomics research through rapid open distribution of public data. Large amounts of raw data are thus transformed into knowledge, which is made available via a multitude ...
Zerbino, Daniel R.; Achuthan, Premanand; Akanni, Wasiu; Amode, M. Ridwan; Barrell, Daniel; Bhai, Jyothish; Billis, Konstantinos; Cummins, Carla; Gall, Astrid; Giron, Carlos Garcia; Gil, Laurent; Gordon, Leo; Haggerty, Leanne; Haskell, Erin; Hourlier, Thibaut; Izuogu, Osagie G.; Janacek, Sophie H.; Juettemann, Thomas; To, Jimmy Kiang; Laird, Matthew R.; Lavidas, Ilias; Liu, Zhicheng; Loveland, Jane E.; Maurel, Thomas; McLaren, William; Moore, Benjamin; Mudge, Jonathan; Murphy, Daniel N.; Newman, Victoria; Nuhn, Michael; Ogeh, Denye; Ong, Chuang Kee; Parker, Anne; Patricio, Mateus; Riat, Harpreet Singh; Schuilenburg, Helen; Sheppard, Dan; Sparrow, Helen; Taylor, Kieron; Thormann, Anja; Vullo, Alessandro; Walts, Brandon; Zadissa, Amonida; Frankish, Adam; Hunt, Sarah E.; Kostadima, Myrto; Langridge, Nicholas; Martin, Fergal J.; Muffato, Matthieu; Perry, Emily; Ruffier, Magali; Staines, Dan M.; Trevanion, Stephen J.; Aken, Bronwen L.; Cunningham, Fiona; Yates, Andrew; Flicek, Paul   +57 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Ensembl 2009 [PDF]

Nucleic Acids Research, 2009
The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases, and other information for chordate, selected model organism and disease vector genomes. As of release 51 (November 2008), Ensembl fully supports 45 species, and three additional species have preliminary ...
Hubbard, T J P, Aken, B L, Ayling, S, Ballester, Benoit, Beal, K, Bragin, E, Brent, S, Chen, Y, Clapham, P, Clarke, L, Coates, G, Fairley, S, Fitzgerald, S, Fernandez-Banet, J, Gordon, L, Graf, S, Haider, S, Hammond, M, Holland, R, Howe, K, Jenkinson, A, Johnson, N, Kahari, A, Keefe, D, Keenan, S, Kinsella, R, Kokocinski, F, Kulesha, E, Lawson, D, Longden, I, Megy, K, Meidl, P, Overduin, B, Parker, A, Pritchard, B, Rios, D, Schuster, M, Slater, G, Smedley, D, Spooner, W, Spudich, G, Trevanion, S, Vilella, A, Vogel, J, White, S, Wilder, S, Zadissa, A, Birney, E, Cunningham, F, Curwen, V, Durbin, R, Fernandez-Suarez, X M, Herrero, J, Kasprzyk, A, Proctor, G, Smith, J, Searle, S, Flicek, P   +57 more
openaire   +4 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source