Results 31 to 40 of about 742,868 (250)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Impact of nutrition route on microaspiration in critically ill patients with shock: a planned ancillary study of the NUTRIREA-2 trial

Critical Care, 2019
Background Microaspiration of gastric and oropharyngeal secretions is the main mechanism of entry of bacteria into the lower respiratory tract in intubated critically ill patients. The aim of this study is to determine the impact of enteral nutrition, as
Saad Nseir, Amélie Le Gouge, Jean-Baptiste Lascarrou, Jean-Claude Lacherade, Emmanuelle Jaillette, Jean-Paul Mira, Emmanuelle Mercier, Pierre-Louis Declercq, Michel Sirodot, Gaël Piton, François Tinturier, Elisabeth Coupez, Stéphane Gaudry, Michel Djibré, Didier Thevenin, Jeremy Pasco, Malika Balduyck, Farid Zerimech, Jean Reignier   +18 more
doaj   +1 more source

Effectiveness of Noninvasive Positive Pressure Ventilation Combined with Enteral Nutrition in the Treatment of Patients with Combined Respiratory Failure after Lung Cancer Surgery and Its Effect on Blood Gas Indexes

Emergency Medicine International, 2022
Purpose. To investigate the effect of noninvasive positive pressure ventilation (NIPPV) combined with enteral nutrition support in the treatment of patients with combined respiratory failure after lung cancer surgery and its effect on blood gas indexes ...
Yongjun Zhang, Lanbo Liu, Dawei Li, Dongsheng Zhou   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Protective effect of gardenia jasminoides ellis and early enteral nutrition on intestinal mucosal barrier in rats with severe acute pancreatitis

Huli yanjiu, 2023
ObjectiveTo explore the protective effect of gardenia jasminoides ellis and early enteral nutrition on intestinal mucosal barrier function in rats with severe acute pancreatic.Methods90 SD rats were randomly divided into control check group，severe acute ...
NIE Yongchun, SU Xiaofang, LI Mingyue, WANG Qinghua   +3 more
doaj  

Enteral nutrition in critically ill children: Are prescription and delivery according to their energy requirements?

, 2007
Background: the purpose of this study was to compare the differences between prescribed and delivered energy among critically ill children and to identify the factors that impede the optimal delivery of enteral nutrition in the first 5 days of nutrition ...
Heitor Pons Leite, Santana e Meneses, Juliana Fernandez, Juliana Fernandez Santana e Meneses, Simone Brasil de Oliveira Iglesias, Werther Brunow de Carvalho, Iglesias, Simone Brasil de Oliveira, Brunow de Carvalho, Werther, Leite, Heitor Pons   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of early postoperative enteral nutrition initiation timing on infection rate and nutritional status in children with congenital heart disease

BMC Pediatrics
Background The optimal timing for initiating enteral nutrition after congenital heart disease surgery remains controversial. This study aimed to evaluate the impact of early versus delayed enteral nutrition initiation on postoperative infection rate and ...
Li Ye, Maoting Chen, Qianling Wei, Yue Wang   +3 more
doaj   +1 more source

Prevention of dexamethasone-induced lymphocytic apoptosis in the intestine and in Peyer patches by enteral nutrition

, 2001
Background. Apoptosis is a programmed cell death, genetically controlled, that can be activated by physiological and pathophysiological events and by the administration of several drugs, including the exogenous administration of corticosteroids.
Díaz-Chico, B. N., Rey, A., López, A., Losada, A., Manzano, J. L., Ruiz-Santana, S., Torres, S., Latasa, L.   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source