Results 61 to 70 of about 197,218 (326)

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Advanced Science, EarlyView.
Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao, Ruiyan Ma, Shuai Hao, Xuxin Tan, Xue Zeng, Rui Song, Bing Chen, Zhezhe Cao, Wei Shen, Zhenchun Luo, Jianfeng Huang, He Huang, Liangming Liu, Chenyang Duan   +13 more
wiley   +1 more source

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, EarlyView.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

High Magnitude of Fecal Carriage of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae at Debre Berhan Comprehensive Specialized Hospital, Ethiopia

Infection and Drug Resistance, 2022
Demissew Shenkute,1 Melese Hailu Legese,2 Berhanu Yitayew,1 Asaye Mitiku,3 Getabalew Engidaye,4 Saba Gebremichael,5 Daniel Asrat,6 Yimtubezinash Woldeamanuel6 1Department of Medical Laboratory Science, College of Health Sciences, Debre Berhan University,
Shenkute D, Legese MH, Yitayew B, Mitiku A, Engidaye G, Gebremichael S, Asrat D, Woldeamanuel Y   +7 more
doaj  

Carbapenem Resistance In Enterobacteriaceae [PDF]

Sohag Medical Journal, 2020
Carbapenem resistance is now a public health concern worldwide. Carbapenem is considered the last resort antimicrobial drug used for treatment of hospital care associated infection and community acquired infection that resistant to all other β-lactam drugs. There are a different mechanisms by which bacteria become resistant to carbapenem drug including
Hasnaa Abo-Elwafa, Radwa Mohammed Farag, Hadir Elmahllawy, Laila M. Yousef   +3 more
openaire   +2 more sources

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

Serotype epidemiology and multidrug resistance patterns of Salmonella enterica infecting humans in Italy [PDF]

, 2016
BACKGROUND: Salmonella enterica is the zoonotic agent most frequently responsible for foodborne infections in humans worldwide. In this work the presence of S.
Bettanello, Sabrina, De Canale, Ettore, Frasson, Ilaria, Palu', Giorgio, Richter, Sara   +4 more
core   +1 more source

Genome plasticity in Enterobacteriaceae

International Journal of Medical Microbiology, 2000
The comparative analysis of multiple representatives of the genomes of particular species are leading us away from a view of bacterial genomes as static, monolithic structures towards the view that they are relatively variable, fluid structures. This plasticity is mainly the result of the rearrangement of genes within the genome and the acquisition of ...
Werner Brunder, Helge Karch
openaire   +3 more sources

The Interplay between the Gut and Ketogenic Diets in Health and Disease

Advanced Science, EarlyView.
This review synthesizes current knowledge on the interaction between ketogenic diets and the gut, covering gut physiology, intestinal immunity, and the gut microbiome. It explores innovative methods for tailoring the diet to maximize benefits while reducing side effects. Emphasis is placed on gut‐mediated mechanisms as a critical interface between diet
Chunlong Mu, Jong M. Rho, Jane Shearer
wiley   +1 more source

Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]

, 2017
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De, Mascellino, Maria Teresa, Oliva, Alessandra   +2 more
core   +1 more source

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source