Results 51 to 60 of about 4,145 (297)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Caracterización molecular de enterobacterias patógenas relacionadas con diarreas neonatales en bovinos. [PDF]

open access: yes, 2020
Antecedentes: Las diarreas infecciosas neonatales en terneros son un problema común en la industria ganadera en el mundo y representa grandes pérdidas económicas.
Vélez Ceballos, Nicolás
core  

Resistencia a los antimicrobianos y concentración inhibitoria mínima (CIM) de enterobacterias aisladas de leche cruda (I)

open access: yesRevista Científica, 2010
A 416 muestras de leche cruda, recolectadas aleatoriamente a nivel de cántaras en 5 receptorías ubicadas en la Cuenca del Lago de Maracaibo del estado Zulia, Venezuela, se les determinó la presencia de antibióticos mediante el Delvotest-P (Gist-Brocades)
José Faría   +3 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Carga bacteriana de los peces Cynoscion squamipinnis (Perciformes: Scianidae) y Lutjanus gutattus (Perciformes: Lutjanidae) en la cadena de comercialización, Costa Rica

open access: yesRevista de Biología Tropical, 2009
Con el fin de determinar la calidad bacteriológica de los productos pesqueros en las diferentes etapas de comercialización, desde marzo del 2004 y hasta febrero del 2006, recolectamos muestras mensuales y realizamos análisis microbiológicos para ...
Carolina Marín   +5 more
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

COMPARAÇÃO ENTRE COLETAS DE AMOSTRAS FECAIS PARA ANÁLISE MICROBIOLÓGICA EM CAMUNDONGOS ORALMENTE TOLERIZADOS

open access: yesBrazilian Journal of Veterinary Medicine, 2013
A análise microbiológica de material fecal pode ser determinada a partir de coletas diretas e indiretas e posterior realização de ensaios bioquí- micos clássicos de identificação bacteriana, estando sua perfeita caracterização diretamente relacionada com
Camilla da Paixão Duarte   +1 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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