Results 61 to 70 of about 822 (260)

Bacteriemia por enterobacterias en adultos en un hospital universitario: análisis de cinco años Bacteremia by enterobacteria in adults from a university hospital: a five year analysis

Revista Argentina de Microbiología, 2007
La bacteriemia sigue siendo una de las causas más importantes de morbilidad y mortalidad en pacientes adultos, a pesar de los numerosos antimicrobianos hoy disponibles y del aumento de las medidas de soporte. El objetivo del presente estudio fue analizar
A. V. Ocaña Carrizo, M. Rocchi, A. Gasparotto, I. Conrero, M. Navarro, S. Factorovich, C. Albrecht, A. Monterisi   +7 more
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Enterobacterias productoras de betalactamasas de espectro extendido en muestras fecales en el Instituto Nacional de Salud del Niño, Perú

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos. Describir la frecuencia de enterobacterias productoras de betalactamasas de espectro extendido (BLEE) en muestras fecales en el Instituto Nacional de Salud del Niño, Lima, Perú. Materiales y métodos.
Fabiola Colquechagua Aliaga, Carlos Sevilla Andrade, Edgar Gonzales Escalante   +2 more
doaj   +2 more sources

Isolamento de Salmonella spp. e Escherichia coli de psittaciformes: relevância em saúde pública

Arquivos do Instituto Biológico, 2016
RESUMO: O tráfico de animais selvagens consiste numa atividade ilegal exercida em diversas partes do mundo, e o Brasil, em função de sua grande extensão territorial e vasta biodiversidade, é um país bastante atingido por essa prática.
Elisângela de Souza Lopes, William Cardoso Maciel, Régis Siqueira de Castro Teixeira, Átilla Holanda de Albuquerque, Ruben Horn Vasconcelos, Débora Nishi Machado, Windleyanne Gonçalves Amorim Bezerra, Isabel Cristina Lima Santos   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Presencia de enterobacterias, Listeria spp., Vibrio spp y Staphylococcus spp en macerados de mosca doméstica (Musca domestica l.), colectada en diferentes sitios relacionados con algunas especies domesticas

Revista Científica, 2012
El presente estudio se llevó a cabo en explotaciones de animales del área metropolitana de Monterrey, Nuevo León y la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Autónoma de Nuevo León.
Jesús Jaime Hernández Escareño, Zaida Melina Rentería Solís, Luis Eduardo Flores Landaverde, Gustavo Hernández Vidal, Arturo Espinoza Mata, Juan José Zárate Ramos   +5 more
doaj  

Evaluación de la capacidad antagonista de un antimicrobiano producido por Streptomyces sp cepa 13a-2 frente a microorganismos resistentes a B-lactámico de origen hospitalario

Revista Peruana de Investigación Materno Perinatal, 2016
Objetivo. Evaluar la actividad antimicrobiana in vitro del actinomiceto marino cepa 13A-2 frente a enterobacterias productoras de P-lactamasas aisladas de pacientes con infecciones urinarias. Material y Métodos.
Mirko Lino-Navarro, Jorge León-Quispe, Mónica Huamán-Iturrizaga   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

[Interpretive reading of enterobacteria antibiograms].

Enfermedades infecciosas y microbiologia clinica, 2010
The resistance pattern observed in the antibiogram of an isolate should be the sum of its natural resistance pattern, characteristic of the species, plus the acquired resistances. In Enterobacteriaceae, the production of inactivating enzymes is the main mechanism of resistance to beta-lactams and aminoglycosides.
Navarro, F, Miro, E, Mirelis, B
openaire   +2 more sources