Results 41 to 50 of about 50,812 (278)

Generalizability analyses with a partially nested trial design: the Necrotizing Enterocolitis Surgery Trial [PDF]

arXiv, 2023
We discuss generalizability analyses under a partially nested trial design, where part of the trial is nested within a cohort of trial-eligible individuals, while the rest of the trial is not nested. This design arises, for example, when only some centers participating in a trial are able to collect data on non-randomized individuals, or when data on ...
arxiv  

A review of the immunomodulating components of maternal breast milk and protection against necrotizing enterocolitis [PDF]

, 2019
Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant\u27s gestational and chronological age, lactation stage, and the mother ...
Fiorentino, Jinquan, Lila S. Nolan, Misty Good, Moe-Byrne, Olivia B. Parks   +5 more
core   +2 more sources

Lower injection‐site reactions and long‐term safety, immunogenicity, and efficacy of etanercept biosimilar YLB113: Results from a post‐hoc analysis of a double‐blind, randomized, phase III comparative study and its open‐label extension in patients with rheumatoid arthritis

International Journal of Rheumatic Diseases, Volume 26, Issue 1, Page 108-115, January 2023., 2023
Abstract Aim YLB113 biosimilar was evaluated in an open‐label extension single‐arm study to assess long‐term safety, efficacy, and immunogenicity in patients with rheumatoid arthritis (RA). We also report post‐hoc results on the incidence of injection‐site reactions (ISRs) and injection‐site erythema (ISE) from a phase III study.
Hisashi Yamanaka, Yoshiya Tanaka, Toshihiko Hibino, Gopalakrishnan Unmesh, Chirag Shah, Dhananjay Bakhle, Dimitris Stefanidis   +6 more
wiley   +1 more source

SURVEILLANCE DATA ON BACTERIAL ENTEROCOLITIS IN BULGARIA FOR 2014-2018

Problems of Infectious and Parasitic Diseases, 2019
Worldwide, 30% of cases of infectious diarrhoea are caused by bacterial pathogens. As in other countries of the European Union, in Bulgaria the most common etiological agents are Escherichia coli (STEC), Salmonella spp., Shigella spp., Campylobacter spp.
Maria Pavlova, V. Velev, Miroslav Karageorgiev, Ekaterina Alexandrova, E. Kamenov, Todor Kantardjiev   +5 more
doaj   +1 more source

The effect of metformin or dipeptidyl peptidase 4 inhibitors on clinical outcomes in metastatic non‐small cell lung cancer treated with immune checkpoint inhibitors

Thoracic Cancer, Volume 14, Issue 1, Page 52-60, January 2023., 2023
Abstract Background Preclinical data have shown the immunomodulatory effects of metformin and dipeptidyl peptidase 4 (DPP4) inhibitors in patients with diabetes. However, its clinical impact remains unclear in lung cancer. Methods Between 2017 and 2021, 466 patients received ICI monotherapy.
Jieun Yang, Se Hyun Kim, Eun Hee Jung, Sang‐A Kim, Koung Jin Suh, Ji Yun Lee, Ji‐Won Kim, Jin Won Kim, Jeong‐Ok Lee, Yu Jung Kim, Keun‐Wook Lee, Jee Hyun Kim, Soo‐Mee Bang, Jong Seok Lee   +13 more
wiley   +1 more source

DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection

Aging Cell, Volume 21, Issue 12, December 2022., 2022
Our data suggest DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection and provide a novel target for anti‐viral intervention. Abstract Coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is known to disproportionately affect older individuals.
Rui Jin, Chang Niu, Fengyun Wu, Sixin Zhou, Tao Han, Zhe Zhang, Entao Li, Xiaona Zhang, Shanrong Xu, Jiadong Wang, Shen Tian, Wei Chen, Qinong Ye, Cheng Cao, Long Cheng   +14 more
wiley   +1 more source

Enteric dysbiosis and fecal calprotectin expression in premature infants. [PDF]

, 2019
BackgroundPremature infants often develop enteric dysbiosis with a preponderance of Gammaproteobacteria, which has been related to adverse clinical outcomes.
A Ghidini, AG Roseth, Akhil Maheshwari, Alyson L. Yee, BC MacQueen, Benjamin A. Torres, Bradley Kane, BS Fullerton, C Rouge, C Urbaniak, CJ Stewart, D Boccia, D Canioni, DC Straus, EA Albanna, F Sommer, FJ Verdam, HH Stone, HM Moore, HR Hill, J Penders, Jack A. Gilbert, JM Rhoads, JP Gisbert, LM Kindinger, M Pammi, M Zhang, Maureen W. Groer, MC Lu, MS Goyal, N Gregersen, PD Smith, PJ Turnbaugh, R Cortese, RM Torrazza, RM Torrazza, SH Patel, Thao T. B. Ho, TTB Ho, VK Gupta, Y Wang, Y Zhou   +41 more
core   +2 more sources

The first documented case of enterocolitis in Yugoslavia caused by enterohemorrhagic Escherichia coli 0517 [PDF]

Vojnosanitetski Pregled, 2003
A ‘new’ group of pathogenic agents, enterohemorrhagic Escherichia coli (EHEC) (particularly the strains of O157 serogroup), emerged in the last 20 years causing an increased number of sporadic and epidemic diarrhoeal diseases with hemorrhagic ...
Čobeljić Miloje, Bojić Ivanko, Opačić Dolores, Lepšanović Zorica, Lazić Srđan   +4 more
doaj   +1 more source

Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia [PDF]

, 2019
BACKGROUND: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in ...
Drucker, Natalie A., Jensen, Amanda R., Markel, Troy A., Te Winkel, Pieter Jan   +3 more
core   +1 more source

The Simple Predictors of Pseudomembranous Colitis in Patients with Hospital-Acquired Diarrhea: A Prospective Observational Study

Gut and Liver, 2014
Background/AimsAs the incidence rate of and mortality from pseudomembranous colitis (PMC) are increasing worldwide, it is important to study the simple predictive risk factors for PMC among patients with hospital-acquired diarrhea (HAD).
doaj   +1 more source