Results 51 to 60 of about 77,920 (294)

Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19

BMJ Open Gastroenterology, 2021
We present a case of haemorrhagic enterocolitis in a patient with SARS-CoV-2 who recovered from respiratory failure after support with venovenous extracorporeal membrane oxygenation.
Warren Carll, M. Rady, M. Salomao, Bhavesh M Patel, Vijay P. Singh, Ayan Sen   +5 more
semanticscholar   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Diagnostic performance of noninvasive tests for cytomegalovirus ileocolitis: a systematic review and meta-analysis [PDF]

Intestinal Research
Background/Aims Diagnosis of cytomegalovirus (CMV) ileocolitis traditionally requires colonoscopy with tissue biopsy. Due to potential complications in high-risk patients, there is growing interest in serum and stool tests for diagnosing this condition ...
Thanaboon Chaemsupaphan, Onuma Sattayalertyanyong, Julajak Limsrivilai   +2 more
doaj   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation

Nature Communications, 2020
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high mortality rate, indicating the need for precision treatment.
Y. Koike, Bo Li, N. Ganji, Haitao Zhu, H. Miyake, Yong Chen, Carol Lee, Maarten Janssen Lok, C. Zozaya, Ethan Lau, Dorothy Lee, S. Chusilp, Zhen Zhang, M. Yamoto, R. Wu, M. Inoue, K. Uchida, M. Kusunoki, P. Delgado-Olguín, L. Mertens, A. Daneman, S. Eaton, P. Sherman, A. Pierro   +23 more
semanticscholar   +1 more source

Clostridium perfringens α and β recombinant toxoids in equine immunization [PDF]

Pesquisa Veterinária Brasileira, 2020
: Clostridium perfringens is considered one of the main causative agents of superacute enterocolitis, usually fatal in the equine species, due to the action of the β toxin, and is responsible for causing severe myonecrosis, by the action of the α toxin ...
Nayra F.Q.R. Freitas, José D. Barbosa, Denis Y. Otaka, Marcos Roberto A. Ferreira, Rafael R. Rodrigues, Clóvis Moreira Jr, Fabricio R. Conceição, Felipe M. Salvarani   +7 more
doaj   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Nutrition in Necrotizing Enterocolitis and Following Intestinal Resection

Nutrients, 2020
This review aims to discuss the role of nutrition and feeding practices in necrotizing enterocolitis (NEC), NEC prevention, and its complications, including surgical treatment.
J. Ou, Cathleen M. Courtney, A. Steinberger, Maria E. Tecos, B. Warner   +4 more
semanticscholar   +1 more source

Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab

Journal for ImmunoTherapy of Cancer, 2021
Introduction Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis.
J. Alexander, H. Ibraheim, Bhavisha P. Sheth, J. Little, Muhammad Saheb Khan, Camellia Richards, N. Hunter, Dharmisha Chauhan, Raguprakash Ratnakumaran, K. Mchugh, D. Pinato, P. Nathan, J. Choy, S. Crusz, A. Furness, S. Turajlic, L. Pickering, J. Larkin, J. Teare, S. Papa, A. Speight, Anand Sharma, N. Powell   +22 more
semanticscholar   +1 more source

Immune Dysregulation in Cancer Patients Undergoing Immune Checkpoint Inhibitor Treatment and Potential Predictive Strategies for Future Clinical Practice

Frontiers in Oncology, 2018
Realization of the full potential of immune checkpoint inhibitor-targeted onco-immunotherapy is largely dependent on overcoming the obstacles presented by the resistance of some cancers, as well as on reducing the high frequency of immune-related adverse
Ronald Anderson, Ronald Anderson, Bernardo L. Rapoport, Bernardo L. Rapoport   +3 more
doaj   +1 more source