Results 111 to 120 of about 10,640,678 (241)

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

Journal of Visualized Experiments, 2017
The gut is the largest endocrine organ of the body, with hormone-secreting enteroendocrine cells located along the length of the gastrointestinal epithelium. Despite their physiological importance, enteroendocrine cells represent only a small fraction of
A. Psichas, G. Tolhurst, Cheryl A. Brighton, F. Gribble, F. Reimann   +4 more
semanticscholar   +1 more source

Regulation of Insulin Secretion Through Long‐Chain Fatty Acid Receptors

iNew Medicine, EarlyView.
Stefan Offermanns
wiley   +1 more source

Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation

Biology Open, 2016
The proliferation of intestinal stem cells (ISCs) and differentiation of enteroblasts to form mature enteroendocrine cells and enterocytes in the Drosophila intestinal epithelium must be tightly regulated to maintain homeostasis.
Mojca Adlesic, Christian Frei, Ian J. Frew   +2 more
doaj   +1 more source

The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine

Nature Communications, 2019
Notch signaling mediates intestinal enteroblast specification in Drosophila but the molecular mechanism as to how this is regulated is unclear. Here, the authors show that the transcription factor Klumpfuss ensures enteroblast commitment through ...
Jerome Korzelius, Sina Azami, Tal Ronnen-Oron, Philipp Koch, Maik Baldauf, Elke Meier, Imilce A. Rodriguez-Fernandez, Marco Groth, Pedro Sousa-Victor, Heinrich Jasper   +9 more
doaj   +1 more source

Intestinal Stem Cells Exhibit Conditional Circadian Clock Function

Stem Cell Reports, 2018
Summary: The circadian clock is a molecular pacemaker that produces 24-hr physiological cycles known as circadian rhythms. How the clock regulates stem cells is an emerging area of research with many outstanding questions.
Kathyani Parasram, Nathaniel Bernardon, Maha Hammoud, Hanna Chang, Li He, Norbert Perrimon, Phillip Karpowicz   +6 more
doaj   +1 more source

Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells

Biomolecules and Therapeutics, 2013
Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on suppressive effects on appetite.
Kim, Hye Young, Park, Min, Kim, Kyong, Lee, Yu Mi, Rhyu, Mee Ra   +4 more
openaire   +3 more sources

A High-Throughput Automated Microfluidic Platform for Calcium Imaging of Taste Sensing

Molecules, 2016
The human enteroendocrine L cell line NCI-H716, expressing taste receptors and taste signaling elements, constitutes a unique model for the studies of cellular responses to glucose, appetite regulation, gastrointestinal motility, and insulin secretion ...
Yi-Hsing Hsiao, Chia-Hsien Hsu, Chihchen Chen   +2 more
doaj   +1 more source

Transdifferentiation of Enteroendocrine K-cells into Insulin-expressing Cells

Korean Diabetes Journal, 2009
Background: Despite a recent breakthough in human islet transplantation for treating type 1 diabetes mellitus, the limited availability of donor pancreases remains a major obstacle. Endocrine cells within the gut epithelium (enteroendocrine cells) and pancreatic β cells share similar pathways of differentiation during embryonic development.
Esder Lee, Jun Mo Yu, Min Kyung Lee, Gyeong Ryul Ryu, Seung-Hyun Ko, Yu-Bae Ahn, Sung-Dae Moon, Ki-Ho Song   +7 more
openaire   +1 more source

Human enteroendocrine cell responses to infection with Chlamydia trachomatis: a microarray study

Gut Pathogens, 2014
BackgroundEnteroendocrine cells (EEC) are highly specialized cells producing signalling molecules vital to the normal functions of the gut. Recently, we showed altered protein distribution in Chlamydia infected EEC in vitro.
A. Dlugosz, S. Muschiol, K. Zakikhany, G. Assadi, M. D’Amato, G. Lindberg   +5 more
semanticscholar   +1 more source

Role of FFAR3 in ketone body regulated glucagon-like peptide 1 secretion

Biochemistry and Biophysics Reports
Background: Roux-en-Y gastric bypass (RYGB) is an effective treatment for obesity, resulting in long-term weight loss and rapid remission of type 2 diabetes mellitus.
Sara MT. Persson, Anna Casselbrant, Aiham Alarai, Erik Elebring, Lars Fändriks, Ville Wallenius   +5 more
doaj   +1 more source