Results 111 to 120 of about 10,616,742 (287)

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

Cell Reports, 2019
Summary: Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are widely
Pierre Larraufie, Geoffrey P. Roberts, Anne K. McGavigan, Richard G. Kay, Joyce Li, Andrew Leiter, Audrey Melvin, Emma K. Biggs, Peter Ravn, Kathleen Davy, David C. Hornigold, Giles S.H. Yeo, Richard H. Hardwick, Frank Reimann, Fiona M. Gribble   +14 more
doaj   +1 more source

Human resident gut microbe Bacteroides thetaiotaomicron regulates colonic neuronal innervation and neurogenic function

Gut Microbes, 2020
Background and aims As the importance of gut–brain interactions increases, understanding how specific gut microbes interact with the enteric nervous system (ENS), which is the first point of neuronal exposure becomes critical.
Rubina Aktar, Nabil Parkar, Regis Stentz, Lucas Baumard, Aimee Parker, Andrew Goldson, Arlaine Brion, Simon Carding, Ashley Blackshaw, Madusha Peiris   +9 more
doaj   +1 more source

Molecular regulation of hormone secretion, growth and apoptosis of GLP-1-producing cells [PDF]

, 2013
Type 2 diabetes (T2D) spreads like an epidemic in today’s society, and there is a great need for new and improved treatments. T2D is characterized by hyperglycemia, resulting from impaired insulin production and insulin resistance in peripheral ...
Kappe, Camilla
core   +1 more source

Pharmacological treatment for patients with obesity and heart failure: Focus on glucagon‐like peptide‐1 receptor agonists. European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, EarlyView.
There is growing clinical interest in strategies for improving clinical outcomes in patients with heart failure (HF) and obesity. The development of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and of the dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 RA has expanded therapeutic options for this population. This expert consensus
Luca Monzo, Gianluigi Savarese, Wilfried Mullens, Amr Abdin, Biykem Bozkurt, Ovidiu Chioncel, Seif El Hadidi, Thomas M. Gorter, Riccardo M. Inciardi, Mark C. Petrie, Gabriele G. Schiattarella, Davide Stolfo, Marco Metra, Nicolas Girerd   +13 more
wiley   +1 more source

Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture

Cell Reports, 2020
Summary: Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine cells
Deborah A. Goldspink, Van B. Lu, Emily L. Miedzybrodzka, Christopher A. Smith, Rachel E. Foreman, Lawrence J. Billing, Richard G. Kay, Frank Reimann, Fiona M. Gribble   +8 more
doaj   +1 more source

Unconventional Functions of Amino Acid Transporters: Role in Macropinocytosis (SLC38A5/SLC38A3) and Diet-Induced Obesity/Metabolic Syndrome (SLC6A19/SLC6A14/SLC6A6)

Biomolecules, 2022
Amino acid transporters are expressed in mammalian cells not only in the plasma membrane but also in intracellular membranes. The conventional function of these transporters is to transfer their amino acid substrates across the lipid bilayer; the ...
Yangzom D. Bhutia, Marilyn Mathew, Sathish Sivaprakasam, Sabarish Ramachandran, Vadivel Ganapathy   +4 more
doaj   +1 more source

Intestinal Enteroendocrine Cells: Present and Future Druggable Targets

International Journal of Molecular Sciences, 2023
Enteroendocrine cells are specialized secretory lineage cells in the small and large intestines that secrete hormones and peptides in response to luminal contents. The various hormones and peptides can act upon neighboring cells and as part of the endocrine system, circulate systemically via immune cells and the enteric nervous system.
Atanga, Roger, Singh, Varsha, In, Julie G.   +2 more
openaire   +2 more sources

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. [PDF]

, 2019
The composition of the gastrointestinal microbiota and associated metabolites changes dramatically with diet and the development of obesity. Although many correlations have been described, specific mechanistic links between these changes and glucose ...
Chan, Luisa S, Chordia, Mahendra D, El Ouarrat, Dalila, Han, Andrew W, Jain, Mohit, Johnson, Andrew MF, Lee, Yun Sok, Mahmood, Nadir A, Ofrecio, Jachelle M, Olefsky, Jerrold M, Pan, Dongfeng, Riopel, Matthew, Ryan, Caitlin N, Watrous, Jeramie D, Wollam, Joshua, Xu, Yong-Jiang, Ying, Wei   +16 more
core   +1 more source

The role of gut endocrine cells in control of metabolism and appetite. [PDF]

, 2014
After food is ingested, nutrients pass through the gastrointestinal tract, stimulating the release of a range of peptide hormones. Among their many local, central and peripheral actions, these hormones act to mediate glucose metabolism and satiety ...
Gribble, Fiona M, Parker, Helen E, Reimann, Frank   +2 more
core   +2 more sources