Results 131 to 140 of about 10,616,742 (287)
New Insights and Perspectives in Congenital Diarrheal Disorders [PDF]
, 2017 Purpose of Review We highlight new entities of congenital diarrheal disorders (CDDs) and progresses in understanding of functionally related genes, opening new diagnostic and therapeutic perspectives.
BERNI CANANI, Roberto +6 more
core +1 more source
Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea
JPGN Reports, EarlyView.Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno +7 more
wiley +1 more source
Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies. [PDF]
, 2015 Congenital diarrhoeal disorders (CDDs) represent an evolving web of rare chronic enteropathies, with a typical onset early in life. In many of these conditions, severe chronic diarrhoea represents the primary clinical manifestation, whereas in others ...
BERNI CANANI, ROBERTO +4 more
core +1 more source
Opportunities of patient‐derived organoids in drug development
British Journal of Pharmacology, EarlyView.Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley +1 more source
Scientific Reports, 2019 Transcription factor Neurod1 is required for enteroendocrine progenitor differentiation and maturation. Several earlier studies indicated that ectopic expression of Neurod1 converted non- neuronal cells into neurons.
H. J. Li +5 more
semanticscholar +1 more source
Cell fluorescence analysis for midgut enteroendocrine cells
, 2022 ImageJ tutorial for creating binary cell image and MatLab script for quantifying fluorescence intensity of three confocal channels. This code pulls out data from relevant Z-stacks only and uses local background for background subtraction.
openaire +1 more source
Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation
Development, Growth &Differentiation, EarlyView.ABSTRACT Adult organs exhibit remarkable plasticity, dynamically adjusting their size and function to meet physiological demands. The small‐intestinal epithelium, one of the most rapidly renewing tissues in mammals, undergoes extensive growth and remodeling in response to diet, injury, microbiota changes, and reproduction.
Tomotsune Ameku
wiley +1 more source
SCFAs strongly stimulate PYY production in human enteroendocrine cells. [PDF]
, 2018 Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes.
Blottiere, HM +6 more
core +3 more sources
Obesity Reviews, EarlyView.ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia +5 more
wiley +1 more source
eLifeCell-to-cell communication via Delta-Notch signaling is widely used in various tissues and organs to regulate development and patterning; however, the mechanisms regulating Notch signaling for precise cell fate decisions remain poorly understood. Similar
Kebei Tang +8 more
doaj +1 more source