Results 141 to 150 of about 10,616,742 (287)

Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia [PDF]

, 2017
Expression of the Ret receptor tyrosine kinase is a defining feature of enteric neurons. Its importance is underscored by the effects of its mutation in Hirschsprung disease, leading to absence of gut innervation and severe gastrointestinal symptoms.
Burns, Alan J., Carroll, Thomas, Guiu, Jordi, Hadjieconomou, Dafni, Hoyer, Nina, Hudry, Bruno, Jensen, Kim B., Kallijärvi, Jukka, Konstantinidou, Chrysoula, Miguel-Aliaga, Irene, Milona, Alexandra, Natarajan, Dipa, Perea, Daniel, Soba, Peter, Thapar, Nikhil, Walker, James A.   +15 more
core   +2 more sources

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

The Journal of Physiology, EarlyView.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista, L. Fernando Santana, Martin G. Martin   +2 more
wiley   +1 more source

Mature enteroendocrine cells contribute to basal and pathological stem cell dynamics in the small intestine.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2018
Lgr5-expressing intestinal stem cells (ISCs) maintain continuous and rapid generation of the intestinal epithelium. Here, we present evidence that dedifferentiation of committed enteroendocrine cells (EECs) contributes to maintenance of the epithelium ...
Y. Sei, Jianying Feng, L. Samsel, Ayla O. White, Xilin Zhao, Sajung Yun, D. Citrin, J. Philip McCoy, Sinju Sundaresan, Michael M. Hayes, J. Merchant, A. Leiter, S. Wank   +12 more
semanticscholar   +1 more source

Postbiotics in Functional Foods: Microbial Derivatives Shaping Health, Immunity and Next‐Generation Nutrition

Food Frontiers, Volume 7, Issue 1, January 2026.
Postbiotics are bioactive compounds derived from microbial fermentation, including short‐chain fatty acids, extracellular polysaccharides, and cell wall components. These molecules support health by regulating immune responses, enhancing gut barrier integrity, reducing inflammation, and modulating gut–brain and gut–liver communication.
Alice Njolke Mafe, Javad Sharifi‐Rad, Daniela Calina, Ayobami Joshua Ogunyemi, Abiola O. Tubi   +4 more
wiley   +1 more source

Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

Nature Communications, 2020
Acetylcholine regulates intestinal epithelial secretion via muscarinic Gq-coupled receptors but its role in cell differentiation is unclear. Here, the authors show that Prox1-positive endocrine cells are sensors for the cholinergic intestinal niche and ...
Moritz Middelhoff, Henrik Nienhüser, Giovanni Valenti, H. Carlo Maurer, Yoku Hayakawa, Ryota Takahashi, Woosook Kim, Zhengyu Jiang, Ermanno Malagola, Krystle Cuti, Yagnesh Tailor, Leah B. Zamechek, Bernhard W. Renz, Michael Quante, Kelley S. Yan, Timothy C. Wang   +15 more
doaj   +1 more source

Microbial regulation of the L cell transcriptome. [PDF]

, 2018
L cells are an important class of enteroendocrine cells secreting hormones such as glucagon like peptide-1 and peptide YY that have several metabolic and physiological effects. The gut is home to trillions of bacteria affecting host physiology, but there
A Wichmann, BO Schroeder, C Arvidsson, C Sternini, CA Brighton, DJ Drucker, DR Donohoe, DV Bohorquez, E Delmee, E Larsson, F Murtagh, F Reimann, F Sommer, F Sommer, F Sommer, FM Gribble, G Tolhurst, G Tolhurst, G Yu, JR Kelly, LV Hooper, ME Johansson, ME Ritchie, P Richards, PD Cani, TS Stappenbeck, V Tremaroli, W Walter   +27 more
core   +3 more sources

Exploring the Role of TAS2Rs in Obesity: Insights From Human and Rat Models

Obesity, Volume 34, Issue 1, Page 162-174, January 2026.
ABSTRACT Objective Obesity is a chronic disease with various causes and diverse treatments, including dietary restriction and bariatric surgery. Bitter taste receptors (TAS2Rs), found in the oral cavity and gastrointestinal tract (GIT), are implicated in digestive and metabolic regulation, but their role in obesity remains unclear.
Maria Descamps‐Solà, Florijan Jalševac, Adrià Vilalta, Margalida Fontcuberta, Harry Park, Carmen Aguilar, Teresa Auguet, Raúl Beltrán‐Debón, Esther Rodríguez‐Gallego, Montserrat Pinent, Ximena Terra, Anna Ardévol   +11 more
wiley   +1 more source

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S [PDF]

, 2014
Activation of plasma membrane TGR5 receptors in enteroendocrine cells by bile acids is known to regulate gastrointestinal secretion and motility and glucose homeostasis.
Ancy D. Nalli, Arun J. Sanyal, Divya P. Kumar, John R. Grider, Karnam S. Murthy, Senthilkumar Rajagopal, Sunila Mahavadi, Vanitha Bala   +7 more
core   +2 more sources

Impact of Semaglutide on fat mass, lean mass and muscle function in patients with obesity: The SEMALEAN study

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 112-121, January 2026.
Abstract Aims Semaglutide, a GLP‐1 receptor agonist, has shown efficacy in promoting weight loss. However, limited data exist on its impact on lean mass, muscle function, and metabolic adaptations. The SEMALEAN study aims to evaluate these parameters in patients with obesity treated with Semaglutide (2.4 mg).
Mathieu Alissou, Thomas Demangeat, Vanessa Folope, Hélène Van Elslande, Hélène Lelandais, Julia Blanchemaison, Pierre‐Emmanuel Cailleaux, Suzan Guney, Alexandra Aupetit, Agnès Aubourg, Clément Rapp, André Petit, Morgane Godin, Luc Vignal, Sébastien Grigioni, Pierre Déchelotte, Guillaume Colange, Moïse Coëffier, Najate Achamrah   +18 more
wiley   +1 more source

Intestinal Differentiation of Mouse ESCs

Bio-Protocol, 2013
ES cells (ESCs) are pluripotent and offer a good tool to study early embryonic development. Intestinal cells are derived from the definitive endoderm. In contrast to adult tissue stem cells, embryonic development and differentiation from ES cells have ...
Soichiro Ogaki, Shoen Kume
doaj   +1 more source