Results 81 to 90 of about 20,295 (209)

Additive Glucagonotropic and Insulinotropic Effects of Glucose‐Dependent Insulinotropic Polypeptide and Alanine in Fasted Healthy Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims/Hypothesis Glucose‐dependent insulinotropic polypeptide (GIP) is a bidirectional glucose‐stabilising hormone potentiating insulin secretion at high glucose levels and glucagon secretion during normal‐to‐low plasma glucose levels. Preclinically, GIP and the amino acid alanine show synergistic glucagonotropic effects at low glucose levels ...
Julie Warnøe, Aliya M. Thomas, David S. Mathiesen, Mathilde K. Preskou, Joachim Størling, Mikkel B. Christensen, Bolette Hartmann, Jens J. Holst, Samuel A. J. Trammell, Jonathan E. Campbell, Thomas F. Dejgaard, Asger B. Lund, Filip K. Knop, Lærke S. Gasbjerg   +13 more
wiley   +1 more source

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Oxytocin has been proposed to exert glucose‐stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin during a graded glucose infusion on glucose‐regulating hormones and
Vivian Kliim‐Hansen, Ida M. Gether, Aliya M. Thomas, Anne‐Marie Ellegaard, Miriam G. Pedersen, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +9 more
wiley   +1 more source

Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells

Molecular Metabolism, 2019
Objective: Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell.
Lawrence J. Billing, Pierre Larraufie, Jo Lewis, Andrew Leiter, Joyce Li, Brian Lam, Giles SH. Yeo, Deborah A. Goldspink, Richard G. Kay, Fiona M. Gribble, Frank Reimann   +10 more
doaj   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Cell fluorescence analysis for midgut enteroendocrine cells

, 2022
ImageJ tutorial for creating binary cell image and MatLab script for quantifying fluorescence intensity of three confocal channels. This code pulls out data from relevant Z-stacks only and uses local background for background subtraction.
openaire   +1 more source

Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review

The FEBS Journal, EarlyView.
This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas, Lucas Vinícius Souza Santos, André Gustavo Carvalho de Oliveira, Marina dos Santos Barreto, Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Eloia Emanuelly Dias Silva, Ronaldy Santana Santos, Lucas Alves da Mota Santana, Rajiv Gandhi Gopalsamy, Adriana Gibara Guimarães, Lysandro Pinto Borges   +11 more
wiley   +1 more source

Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Electroacupuncture (EA) reshapes intestinal flora; whether post‐EA fecal microbiota transplantation (post‐EA FMT) regulates gastrointestinal hormones via the gut microbiota–bile acid (BA) pathway remains unclear. Methods Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post‐EA.
Yong‐Li Han, Dong‐Fang Shang, Juli Tang, Dong‐Dong Yu, Liang‐Yu Zhang, Jing Zhou, Qing‐Bo Wang   +6 more
wiley   +1 more source

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Combination of In Ovo Nutritional Components Improves Embryonic Development, Growth Performance, and Gut Health in Broiler Chickens

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study evaluated the effects of intra‐amniotic administration of combined energy, amino acid, and vitamin sources on embryonic development, post‐hatch growth performance, and intestinal health in broiler chickens. On Day 18 of incubation, 460 fertile Ross 308 eggs were allocated to four groups: non‐injected negative control (NC), saline ...
Derya Yeşilbağ, Fulya Odabaşi Erbay, Ender Deniz Asmaz, Berrin Zik, Artun Yibar, Hilmi Can Acar, Engin Erbay, Kadir Yeşilbağ   +7 more
wiley   +1 more source

A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila

Stem Cell Reports, 2018
Summary: The intestinal epithelium in the Drosophila midgut is maintained by intestinal stem cells (ISCs), which are capable of generating both enterocytes and enteroendocrine cells (EEs) via alternative cell fate specification. Activation of Delta-Notch
Chang Yin, Rongwen Xi
doaj   +1 more source