Results 51 to 60 of about 11,603 (201)

An Epidemic of Bloody Diarrhea: Escherichia coli O157 Emerging in Cameroon?

Emerging Infectious Diseases, 1999
Between November 1997 and April 20, 1998, bloody diarrhea sickened 298 persons in Cameroon. Laboratory investigation of the epidemic (case-fatality rate, 16.4%) documented amoebiasis in one of three patients and three types of pathogens: multidrug ...
Patrick Cunin, Etienne Tedjouka, Yves Germani, Chouaïbou Ncharre, Raymond Bercion, Jacques Morvan, Paul M.V. Martin   +6 more
doaj   +1 more source

Intestinal damage in enterohemorrhagic Escherichia coli infection [PDF]

Pediatric Nephrology, 2011
Enterohemorrhagic Escherichia coli (EHEC) infection leads to marked intestinal injury. Sigmoid colon obtained from two children during EHEC infection exhibited abundant TUNEL-positive cells. To define which bacterial virulence factors contribute to intestinal injury the presence of Shiga toxin-2 (Stx2), intimin and the type III secretion system were ...
Békassy, Zivile, Calderon Toledo, Carla, Leoj, Gustav, Kristoffersson, Ann-Charlotte, Leopold, Shana R, Perez, Maria Thereza, Karpman, Diana   +6 more
openaire   +3 more sources

The Synergy Between a Silver‐Ruthenium Antimicrobial and Aminoglycosides Is Based on Severe Macromolecular Damage

Molecular Microbiology, EarlyView.
AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Emmanuel P. Oladokun, Gracious Y. Donkor, Julius K. Narh, Grady D. Jacobson, Cade Ward, Patrick O. Tawiah, Lisa K. Polzer, Kevin A. Edwards, Kyle A. Floyd, Jan‐Ulrik Dahl   +9 more
wiley   +1 more source

Characterization of SepL of Enterohemorrhagic Escherichia coli [PDF]

Journal of Bacteriology, 2000
ABSTRACT The sepL gene is expressed in the locus of enterocyte effacement and therefore is most likely implicated in the attaching and effacing process, as are the products encoded by open reading frames located up- and downstream of this gene.
A U, Kresse, F, Beltrametti, A, Müller, F, Ebel, C A, Guzmán   +4 more
openaire   +2 more sources

Evolution of N‐terminal mechanical lability as a determinant for Type III secretion

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Many Gram‐negative pathogens critically depend on the Type III secretion system (T3SS) to inject effector proteins into host cells for colonization. Because the channel of the T3SS is narrow (~2 nm), effectors must be unfolded for secretion.
Katherine E. DaPron, Alexandre M. Plastow, Morgan R. Fink, Brandon Dzuba, Marc‐Andre LeBlanc, Thomas T. Perkins, Emad Tajkhorshid, Marcelo C. Sousa   +7 more
wiley   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, Volume 32, Issue 25, 2 July 2026.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Bridging the Gap Between General and Transplant Infectious Disease Practice

Transplant Infectious Disease, Volume 28, Issue 4, July/August 2026.
ABSTRACT The population of iatrogenic immunocompromised individuals is steadily rising as we continue to improve in our ability to manage diseases, including cancer, autoimmune disease, and end‐organ dysfunction, with increasing access to novel agents and transplantation.
Jeremey Walker, Emily Eichenberger, Steven Pergam, Maricar Malinis, Andrea J. Zimmer   +4 more
wiley   +1 more source

Enterohemorrhagic Escherichia coli—The Australian Perspective

Journal of Food Protection, 1997
Food borne transmission of hemolytic uremic syndrome (HUS) was first reported in Australia in 1995 when an outbreak of HUS due to Escherichia coli O111 occurred following the consumption of locally produced mettwurst. Federal and state health and food authorities responded rapidly to bring the outbreak under control.
openaire   +2 more sources

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Analysis of Collection of Hemolytic Uremic Syndrome–associated Enterohemorrhagic Escherichia coli

Emerging Infectious Diseases, 2008
Multilocus sequence typing of 169 non-O157 enterohemorrhagic Escherichia coli (EHEC) isolated from patients with hemolytic uremic syndrome (HUS) demonstrated 29 different sequence types (STs); 78.1% of these strains clustered in 5 STs.
Alexander Mellmann, Martina Bielaszewska, Robin Köck, Alexander W. Friedrich, Angelika Fruth, Barbara Middendorf, Dag Harmsen, M. Alexander Schmidt, Helge Karch   +8 more
doaj   +1 more source