Results 211 to 220 of about 21,092 (255)
Some of the next articles are maybe not open access.
Enterohepatic Circulation of Unconjugated Bilirubin in Man
Nature, 1962A S, GILBERTSEN +2 more
openaire +4 more sources
Clinical Pharmacokinetics, 2002
Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often associated with multiple peaks and a longer apparent half-life in a plasma concentration-time profile.
Roberts, M. S. +3 more
openaire +3 more sources
Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often associated with multiple peaks and a longer apparent half-life in a plasma concentration-time profile.
Roberts, M. S. +3 more
openaire +3 more sources
Modeling Enterohepatic Circulation
Current Pharmacology Reports, 2017The objective of the current analysis is to review the anatomy and physiology of the enterohepatic circulation (EHC); describe how those intricacies affect drug concentration profiles; present various pharmacokinetic models used in the literature to describe EHC concentration-time data; and provide a categorization of these models based on common ...
Malek Okour, Richard C. Brundage
openaire +1 more source
Canine bile acid enterohepatic circulation
Steroids, 1982The enterohepatic circulation (EHC) of bile acids has been studied in fasting dogs with portacaval shunt maintained in the steady state. In such animals the rate of EHC is proportional to systemic blood bile acid concentration. Bile acid EHC was irregular (20 to 100% variation) when measured at 15 minute or hourly intervals.
W T, Beher +4 more
openaire +2 more sources
THE ENTEROHEPATIC CIRCULATION OF THYROXINE
Journal of Endocrinology, 1972SUMMARY A quantitative investigation was made of the enterohepatic circulation of endogenous thyroxine (T4) in the rat. Control and cold-acclimated rats were maintained on a low iodine diet and water containing 125I-labelled iodide of known specific activity for 4 weeks. Faeces were then collected over a 3-day period.
V A, Galton, B C, Nisula
openaire +2 more sources
Enterohepatic Circulation of Drugs
The Journal of Clinical Pharmacology, 1989Review on the processes of biliary excretion and enterohepatic circulation of drugs and the pharmacokinetic and pharmacodynamic consequences ...
openaire +2 more sources
Cysteinyl leukotrienes undergo enterohepatic circulation
Prostaglandins, Leukotrienes and Medicine, 1986Abstract Enterohepatic circulation is an important mechanism responsible for extension of the biological half-lives of many endogenous compounds and xenobiotics (1). Cysteinyl leukotrienes play an important role in lethal endotoxin action (2) and in tissue trauma (3).
C, Denzlinger +7 more
openaire +2 more sources
Enterohepatic circulation of sulindac and metabolites
Clinical Pharmacology and Therapeutics, 1983Four subjects were studied by continuous intraduodenal sampling to establish the existence and determine the extent of enterohepatic recirculation of sulindac and its sulfide and sulfone metabolites. Sulindac, 200 mg by mouth, was given every 12 hr for 7 days.
C A, Dujovne +5 more
openaire +2 more sources
2020
The term “Enterohepatic circulation” (EHC) refers to the circulation of metabolites from the intestine to the liver and back to the intestine. Since the first use of the term in 1923, understanding of the detailed physiology, microanatomy, and biochemistry, and of interactions between organs and tissues, has grown dramatically.
openaire +1 more source
The term “Enterohepatic circulation” (EHC) refers to the circulation of metabolites from the intestine to the liver and back to the intestine. Since the first use of the term in 1923, understanding of the detailed physiology, microanatomy, and biochemistry, and of interactions between organs and tissues, has grown dramatically.
openaire +1 more source
Crohn's disease and the enterohepatic circulation
Medical Hypotheses, 1981Crohn's disease is a chronic inflammatory process which may affect any part of the alimentary tract. This cause is unknown. Overall the distribution of the lesions coincides with that of the enterohepatic circulation. A possible causative agent is a metabolic or ingested substance excreted into the bile in the form of a polar and inactive conjugates ...
H, Nyhlin, M A, Eastwood
openaire +2 more sources