Results 81 to 90 of about 51,443 (168)

Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Bloodstream infections (BSIs) pose a significant global health challenge, particularly in developing countries. Neonates are highly vulnerable due to underdeveloped immune systems and immature physical barriers, a risk amplified by poor hygiene and limited healthcare access in low‐ and middle‐income countries (LMICs), leading to an ...
Alex Odoom, Abdul‐Halim Osman, Onyansaniba K. Ntim, Fleischer C. N. Kotey, Eric S. Donkor   +4 more
wiley   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

The Burden of Viral Respiratory Infections in Immunosuppressed Inflammatory Bowel Disease Patients

JGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Background and Aim Due to the increasing immunosuppressant use in inflammatory bowel disease (IBD) and the risk of serious infections, this study investigates the prevalence and risk factors of respiratory pathogen detection in this population to improve patient care.
D. Huynh, E. Khoo, A. Shanmuga Anandan, J. Begun   +3 more
wiley   +1 more source

Human Metapneumovirus Versus Respiratory Syncytial Virus in the Pediatric Emergency Department: Inflammatory Indices, Cycle‐Threshold Profiles and Outcomes

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Inflammatory‐biomarker, cycle‐threshold (Ct) and co‐detection data on human metapneumovirus (hMPV) in the pediatric emergency department remain scarce. We retrospectively studied 203 children with multiplex RT‐PCR–confirmed respiratory virus positivity at a tertiary pediatric emergency department (January–May 2025).
Yılmaz Seçilmiş, Gülşah Kartal, Muhammet Sami Kayan, Mesut Kara, Ömür Mustafa Parkan, Selma Gökahmetoğlu   +5 more
wiley   +1 more source

Acute Myocarditis: From Pathophysiology to Risk‐Stratified Management—A Clinical Review

European Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.
Stepwise approach to patients with suspected acute myocarditis, integrating the 2024 American College of Cardiology (ACC) four‐stage classification (Stages A–D) and the 2025 European Society of Cardiology (ESC) inflammatory myopericardial syndrome (IMPS) framework. Step 1 (Initial Assessment): clinical presentation, first‐line investigations (ECG, high‐
Michele Golino, Marco Giuseppe Del Buono, Michele Marchetta, Nicola Potere, Aldo Bonaventura, Alessandra Vecchiè, Danilo Malandrino, Giacomo Emmi, Jordana Kron, Antonio Abbate   +9 more
wiley   +1 more source

Leucoverdazyls as Novel Potent Inhibitors of Enterovirus Replication

Pathogens
Enteroviruses (EV) are important pathogens causing human disease with various clinical manifestations. To date, treatment of enteroviral infections is mainly supportive since no vaccination or antiviral drugs are approved for their prevention or ...
Alexandrina S. Volobueva, Tatyana G. Fedorchenko, Galina N. Lipunova, Marina S. Valova, Valeriya A. Sbarzaglia, Anna S. Gladkikh, Olga I. Kanaeva, Natalia A. Tolstykh, Andrey N. Gorshkov, Vladimir V. Zarubaev   +9 more
doaj   +1 more source

Regulation of viral replication by host restriction factors

Frontiers in Immunology
Viral infectious diseases, caused by numerous viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), enterovirus (EV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), and human papillomavirus
Ying Lin, Ying Lin, Ying Lin, Yun Zhu, Yun Zhu, Ling Jing, Ling Jing, Ling Jing, Xiaobo Lei, Xiaobo Lei, Zhengde Xie, Zhengde Xie   +11 more
doaj   +1 more source

Respiratory Viral Infections and the Tonsillar Transcriptome: An Exploratory Study

Clinical &Experimental Allergy, Volume 56, Issue 8, Page 932-934, August 2026.
Tanzeela Hanif, Lotta E. Ivaska, Antti Silvoniemi, Emilia Mikola, Tuomo Puhakka, Oscar Palomares, Sanna Toppila‐Salmi, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti   +9 more
wiley   +1 more source

Changes in Seasonal Patterns of Pediatric Respiratory Viral Infections Before, During, and After the COVID-19 Pandemic: A Seventeen-Year Surveillance Study in the Republic of Korea

Viruses
The coronavirus disease 19 pandemic disrupted pediatric respiratory infections through non-pharmaceutical interventions and altered contact patterns. Long-term comparisons across the pandemic timeline in children remain limited.
Mi-Ru Oh, Jeong Su Han, Jae-Sik Jeon, Jae Kyung Kim   +3 more
doaj   +1 more source

Molecular evolution and circulation dynamic of human non-polio enteroviruses across Africa

International Journal of Infectious Diseases
Objectives: Human non-polio enteroviruses represent major public health concerns due to frequent outbreaks. Our study used genomic data to analyze the molecular epidemiology and circulation pattern of NPEVs in Africa, assess their inter-host transmission
Serigne Fallou MBacké NGom, NDack Ndiaye, Ousmane Kébé, NDongo Dia, Martin Faye   +4 more
doaj   +1 more source