Results 61 to 70 of about 52,040 (206)

Streptococcus pneumoniae nasal carriage patterns with and without common respiratory virus detections in households in Seattle, WA, USA before and during the COVID-19 pandemic

Frontiers in Pediatrics, 2023
BackgroundRespiratory viruses might influence Streptococcus pneumoniae nasal carriage and subsequent disease risk. We estimated the association between common respiratory viruses and semiquantitative S.
Julia C. Bennett, Julia C. Bennett, Anne Emanuels, Jessica Heimonen, Jessica O'Hanlon, James P. Hughes, Peter D. Han, Peter D. Han, Eric J. Chow, Eric J. Chow, Eric J. Chow, Constance E. Ogokeh, Constance E. Ogokeh, Melissa A. Rolfes, Christine M. Lockwood, Christine M. Lockwood, Brian Pfau, Brian Pfau, Timothy M. Uyeki, Jay Shendure, Jay Shendure, Samara Hoag, Kairsten Fay, Jover Lee, Thomas R. Sibley, Julia H. Rogers, Julia H. Rogers, Lea M. Starita, Lea M. Starita, Janet A. Englund, Helen Y. Chu   +30 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Pairwise nucleotide and amino acid sequence identities between human enterovirus 85 strains and prototype strains of the HEV-B species.

, 2013
Pairwise nucleotide and amino acid sequence identities between human enterovirus 85 strains and prototype strains of the HEV-B species.
Guohong Huang (285758), Qiang Sun (225630), Huifang Tian (285755), Jing Li (10611), Huafang Jiang (285764), Xiaolei Li (102381), Wenbo Xu (148718), Bo Zhang (6559), Xiaojuan Tan (195499), Shuangli Zhu (195480), Hui Zhu (87035), Zhen Zhu (104773), Yong Zhang (5893), Peng Zheng (187813), Hui Cui (285760), Dongmei Yan (195489), Hongqiu An (195503)   +16 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

High frequency of human enterovirus species C circulation in Madagascar.

, 2005
International audienceFour poliomyelitis outbreaks caused by vaccine-derived polioviruses have been reported recently, including one in Madagascar in 2002.
Rakoto-Andrianarivelo, Mala, S. Chevaliez, S. Guillot, Rousset, Dominique, Razafindratsimandresy, Richter, Guillot, Sophie, Balanant, Jean, D. Rousset, J. Balanant, R. Razafindratsimandresy, Delpeyroux, Francis, M. Rakoto-Andrianarivelo, F. Delpeyroux, Chevaliez, Stéphane   +13 more
core   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Epidemics and Frequent Recombination within Species in Outbreaks of Human Enterovirus B-Associated Hand, Foot and Mouth Disease in Shandong China in 2010 and 2011

PLoS ONE, 2013
The epidemiology and molecular characteristics of human enterovirus B (HEV-B) associated with hand, foot and mouth disease (HFMD) outbreaks in China are not well known. In the present study, we tested 201 HEV isolates from 233 clinical specimens from patients with severe HFMD during 2010-2011 in Linyi, Shandong, China.
Ting Zhang, Jiang Du, Ying Xue, Haoxiang Su, Fan Yang, Qi Jin   +5 more
openaire   +4 more sources

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

Enterovirus 2Apro targets MDA5 and MAVS in infected cells [PDF]

, 2014
UNLABELLED: RIG-I-like receptors (RLRs) MDA5 and RIG-I are key players in the innate antiviral response. Upon recognition of viral RNA, they interact with MAVS, eventually inducing type I interferon production.
Bhoopathi, Praveen, Lloyd, Richard E, Lork, Marie, Feng, Qian, I&I SIB1, Nguyen, Mai, van Kuppeveld, Frank J M, Hato, Stanleyson V, Strategic Infection Biology, Langereis, Martijn A, Emdad, Luni, LS Virologie, Fisher, Paul B, Lanke, Kjerstin   +13 more
core   +2 more sources