Results 41 to 50 of about 52,040 (206)

Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions

Journal of General Virology, 2005
The complete nucleotide sequences of eight Human enterovirus B (HEV-B) strains were determined, representing five serotypes, E6, E7, E11, CVB3 and CVB5, which were isolated in the former Soviet Union between 1998 and 2002. All strains were mosaic recombinants and only the VP2–VP3–VP1 genome region was similar to that of the corresponding prototype HEV ...
Alexander N, Lukashev, Vasilii A, Lashkevich, Olga E, Ivanova, Galina A, Koroleva, Ari E, Hinkkanen, Jorma, Ilonen   +5 more
openaire   +2 more sources

Recombination in enteroviruses is a biphasic replicative process involving the generation of greater-than genome length 'imprecise' intermediates [PDF]

, 2014
Recombination in enteroviruses provides an evolutionary mechanism for acquiring extensive regions of novel sequence, is suggested to have a role in genotype diversity and is known to have been key to the emergence of novel neuropathogenic variants of ...
David J Evans, Woodman, Andrew, Andrew Woodman, Kym Lowry (222718), Jonathan Cook (3435386), Andrew Woodman (577477), Cook, Jonathan, Cook, Jonathan P., David J. Evans (208308), Lowry, Kym, David J. Evans, Evans, David J., Kym Lowry, Jonathan Cook   +13 more
core   +1 more source

Temporal Co-circulation Patterns of Respiratory Pathogens in South Africa, 2024: A Retrospective Analysis of Private Laboratory Surveillance Data [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases
Background and study aim: Respiratory tract infections cause substantial morbidity, and multiplex polymerase chain reaction (PCR) testing demonstrates concurrent circulation of multiple respiratory pathogens.
Somasundram Pillay
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Monitoring antigenic variations of enterovirus 71: implications for virus surveillance and vaccine development. [PDF]

PLoS Neglected Tropical Diseases, 2014
Enterovirus 71 (EV71) causes life-threatening epidemics in Asia and can be phylogenetically classified into three major genogroups (A ∼ C) including 11 genotypes (A, B1 ∼ B5, and C1 ∼ C5).
Min-Yuan Chia, Wan-Yu Chung, Pai-Shan Chiang, Yeh-Sheng Chien, Mei-Shang Ho, Min-Shi Lee   +5 more
doaj   +1 more source

Effects of Nonpharmaceutical COVID-19 Interventions on Pediatric Hospitalizations for Other Respiratory Virus Infections, Hong Kong

Emerging Infectious Diseases, 2022
To determine the effects of nonpharmaceutical interventions (NPIs) for coronavirus disease on pediatric hospitalizations for infection with respiratory viruses other than severe acute respiratory syndrome coronavirus 2, we analyzed hospital data for ...
Susan S. Chiu, Benjamin J. Cowling, J.S. Malik Peiris, Eunice L.Y. Chan, Wilfred H.S. Wong, Kwok Piu Lee   +5 more
doaj   +1 more source

Molecular diagnosis of echovirus 30 as the etiological agent in an outbreak of aseptic meningitis in Panama: May – June 2008

Journal of Infection in Developing Countries, 2012
Introduction: Aseptic meningitis outbreaks are commonly caused by viral pathogens with enterovirus a common etiological agent. Between May and June of 2008, an outbreak of 173 cases of aseptic meningitis occurred in the Chiriqui Province of Panama ...
Alexander A Martinez, Juan Castillo, Mirla C Sanchez, Yamitzel Zaldivar, Yaxelis Mendoza, Maribel Tribaldos, Pablo Acosta, Rebecca E Smith, Juan Miguel Pascale   +8 more
doaj   +1 more source

Protective efficacy of VP1-specific neutralizing antibody associated with a reduction of viral load and pro-inflammatory cytokines in human SCARB2-transgenic mice. [PDF]

PLoS ONE, 2013
Hand-foot-mouth diseases (HFMD) caused by enterovirus 71 (EV71) and coxsackievirus 16 (CVA16) in children have now become a severe public health issue in the Asian-Pacific region.
Hsuen-Wen Chang, Yi-Wen Lin, Hui-Min Ho, Min-Han Lin, Chia-Chyi Liu, Hsiao-Yun Shao, Pele Chong, Charles Sia, Yen-Hung Chow   +8 more
doaj   +1 more source

Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody

Viruses, 2022
Echovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the ...
Shuai Qi, Wangjun Fu, Jinyan Fan, Li Zhang, Binyang Zheng, Kang Wang, Xiangxi Wang, Ling Zhu, Xinjian Li, Yuxia Zhang   +9 more
doaj   +1 more source

Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV ...
Ulferts, R., van der Linden, L., Thibaut, H.J., Lanke, K.H.W., Leyssen, P., Coutard, B., De Palma, A.M., Canard, B., Neyts, J., van Kuppeveld, F.J.M., van Kuppeveld, F.J.M.   +10 more
openaire   +5 more sources