Results 41 to 50 of about 44,128 (189)

Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021

Viruses, 2022
Infection with enterovirus D68 (EV-D68) has been linked with severe neurological disease such as acute flaccid myelitis (AFM) in recent years. However, active surveillance for EV-D68 is lacking, which makes full assessment of this association difficult ...
Alison Tedcastle, Thomas Wilton, Elaine Pegg, Dimitra Klapsa, Erika Bujaki, Ryan Mate, Martin Fritzsche, Manasi Majumdar, Javier Martin   +8 more
doaj   +1 more source

Molecular identification and characterization of two proposed new enterovirus serotypes, EV74 and EV75. [PDF]

, 2004
Sequencing of the gene that encodes the capsid protein VP1 has been used as a surrogate for antigenic typing in order to distinguish enterovirus serotypes; three new serotypes were identified recently by this method.
Lau, Cs, Uddin, M., Oberste, Ms, Magnius, Lo, Ridha, W., Schnurr, D., Cisterna, D., Norder, H., Pallansch, Ma, Chomel, Jj, Junttila, N., Al-Busaidy, S., Michele, Sm, Maher, K.   +13 more
core   +2 more sources

A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier

mSphere, 2017
The blood-brain barrier (BBB) comprises the foremost protective barrier in the brain and is composed in part of a layer of microvascular endothelial cells that line the capillaries surrounding the brain.
John C. Bramley, Coyne G. Drummond, Nicholas J. Lennemann, Charles A. Good, Kwang Sik Kim, Carolyn B. Coyne   +5 more
doaj   +1 more source

A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells

mSphere, 2016
Despite serving as the primary entry portal for coxsackievirus B (CVB), little is known about CVB infection of the intestinal epithelium, owing at least in part to the lack of suitable in vivo models and the inability of cultured cells to recapitulate ...
Coyne G. Drummond, Cheryl A. Nickerson, Carolyn B. Coyne   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis

, 2010
BACKGROUND: The authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) based on expression of 88 human genes.
Gough, J, Kerr, JR, Honeybourne, David, Richards, SC, Ayres, JG, Mattey, DL, Enlander, D, Zhang, L, Ayres, Jonathan, Richards, Selwyn C M, Christmas, D, Main, J, Honeybourne, D, Nutt, DJ   +13 more
core   +1 more source

Surveillance for respiratory and diarrheal pathogens at the human-pig interface in Sarawak, Malaysia. [PDF]

PLoS ONE, 2018
BACKGROUND:The large livestock operations and dense human population of Southeast Asia are considered a hot-spot for emerging viruses. OBJECTIVES:To determine if the pathogens adenovirus (ADV), coronavirus (CoV), encephalomyocarditis virus (EMCV ...
Laura K Borkenhagen, Kerry A Mallinson, Rick W Tsao, Siaw-Jing Ha, Wei-Honn Lim, Teck-Hock Toh, Benjamin D Anderson, Jane K Fieldhouse, Sarah E Philo, Kuek-Sen Chong, William G Lindsley, Alejandro Ramirez, James F Lowe, Kristen K Coleman, Gregory C Gray   +14 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source