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Enterovirus D68 Antivirals: Past, Present, and Future
ACS Infectious Diseases, 2020 Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in children. In severe cases, it can lead to neurological complications such as acute flaccid myelitis (AFM). EV-D68 belongs to the enterovirus genera of the Picornaviridae family, which also includes many other significant human pathogens such as poliovirus, enterovirus ...
Jun Wang, Yanmei Hu, Rami Musharrafieh
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Enterovirus D68 Infection in an Adult
American Journal of Critical Care, 2016The first confirmed US case of severe respiratory tract infection caused by enterovirus D68 in an adult occurred in a pregnant woman with no history of asthma in August 2014. Before she came to the hospital, she had a productive cough, headache, and increasing dyspnea.
Nicholas S, Ward +2 more
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Insights into the molecular evolution of enterovirus D68
Archives of Virology, 2023Enterovirus D68 (EV-D68) is a respiratory virus that primarily affects children and has been associated with sporadic outbreaks of respiratory illness worldwide. In the present study, temporal spreading and molecular evolution of EV-D68 clades (A1, A2, B, B1, B2, B3, and C) were evaluated.
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Receptor-Binding Assays of Enterovirus D68
2020Human enterovirus D68 (EV-D68) is a causative agent for acute respiratory infections and potentially central nervous system illnesses with increasing epidemiological significance. Recent studies have highlighted the role of sialic acids as a functional receptor for EV-D68 in vitro. However, further investigations are required to reveal its significance
Tadatsugu, Imamura +2 more
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Pediatric Infectious Disease Journal, 2020
Background: Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.
Tatsuki, Ikuse +6 more
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Background: Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.
Tatsuki, Ikuse +6 more
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Clinical Course of Enterovirus D68 in Hospitalized Children
Pediatric Infectious Disease Journal, 2017Enterovirus D68 (EV-D68) has been sporadically reported as a cause of respiratory tract infections. In 2014, an international outbreak of EV-D68 occurred and caused severe respiratory disease in the pediatric population.A retrospective chart review was performed of children admitted to Children's Mercy Hospital from August 1, 2014, to September 15 ...
Jennifer E, Schuster +11 more
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Poliomyelitis Is an Enterovirus Acute Flaccid Myelitis and Enterovirus D68
Pediatric Annals, 2022Joseph R, Hageman +1 more
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Global Evolution and Transmission Dynamics of Enterovirus D68
Journal of Medical VirologyABSTRACT Enterovirus D68 (EV‐D68), a serotype of the enterovirus species D, has garnered significant attention due to outbreaks reported in 2014, 2016, and 2018. In this study, 36 Chinese EV‐D68 strains were isolated, sequenced, and combined with all EV‐D68 VP1 sequences ...
Mengyi Xiao +18 more
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MFSD6 is an entry receptor for respiratory enterovirus D68
Cell Host & MicrobeEnterovirus D68 (EV-D68) is a leading non-polio enterovirus that causes severe respiratory diseases and poliomyelitis-like illness in children. Viral entry represents a potential multifaceted target for antiviral intervention; however, there are no approved inhibitors to block EV-D68.
Xize Liu +16 more
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