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Acute respiratory infections [PDF]
Current Problems in Pediatrics, 1974 In conclusion, the purpose of this dissertation has been to review the data on acute respiratory infections as to etiology, pathogenicity, clinical syndromes and treatment. It would take volumes to adequately discuss respiratory infections in all their complexity, and by the time any manuscript gets into print, it is likely to be outdated because of ...
D S, Seto, R M, Heller
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The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Nature Communications, 2020 Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary ...
Takanori Furukawa +22 more
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Lung colonization by Aspergillus fumigatus is controlled by ZNF77
Nature Communications, 2018 Aspergillus fumigatus regularly colonises the lungs but in the context of respiratory disease can be associated with increased pathology. Here the authors show mutations in ZNF77 result in altered bronchial epithelial characteristics and enhanced fungal ...
Sara Gago +6 more
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Paediatric respiratory infections [PDF]
European Respiratory Review, 2016 Pulmonary infections remain a major cause of infant and child mortality worldwide and are responsible for a substantial burden of morbidity. During the 2015 European Respiratory Society International Congress in Amsterdam, some of the main findings from peer-reviewed articles addressing this topic that were published in the preceding 12 months were ...
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Variable DNA methylation of aging-related genes is associated with male COPD
Respiratory Research, 2019 Background Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age.
Xizi Du +13 more
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Scientific Reports, 2018 Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. KCa3.1 ion channels play a critical role in TGFβ1-dependent pro-fibrotic responses in human lung myofibroblasts.
Katy M. Roach +6 more
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Asthma Diagnosis: The Changing Face of Guidelines
Pulmonary Therapy, 2019 Asthma, the most common chronic respiratory disease, is frequently misdiagnosed, and accounts for a significant proportion of healthcare expenditure. This has driven the National Institute for Health and Care Excellence (NICE) in the United Kingdom (UK ...
Sarah M. Drake +2 more
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Stem Cell Research & Therapy, 2020 Background Proliferation and transdifferentiation of lung stem cells (LSCs) could promote lung injury repair. The distal airways of the lung are innervated by the vagus nerve.
Xiaoyan Chen +8 more
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, 2014 The respiratory tract is a common site of infection in cancer patients and is associated with substantial moribidity and mortality in this population. Cancer, chemotherapy, and radiation can all cause noninfectious pulmonary infiltrates and respiratory symptoms that can masquerade as a respiratory tract infection.
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Cell Communication and Signaling, 2020 Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in China. The lack of an effective treatment for this disease results in a high recurrence rate in patients who undergo radical tumor resection, and the 5-year
Benfan Wang +6 more
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