Results 11 to 20 of about 1,055,922 (317)

Respiratory infections and asthma [PDF]

Respiratory Medicine, 2006
Respiratory tract infections caused by both viruses and/or atypical bacteria are involved in the pathogenesis of asthma. In particular, several viruses such as respiratory syncytial virus, rhinovirus and influenza/parainfluenza viruses may favour the expression of the asthmatic phenotype, being also implicated in the induction of disease exacerbations.
Pelaia G, VATRELLA, Alessandro, Gallelli L, Renda T, Cazzola M, Maselli R, Marsico S.A.   +6 more
openaire   +5 more sources

Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding [PDF]

, 2015
RSV is the most important viral cause of pneumonia and bronchiolitis in children worldwide and has been associated with significant disease burden. With the renewed interest in RSV vaccines, we provide realistic estimates on duration, and influencing ...
Agoti, Charles N., Munywoki, Patrick Kiio, Koech, Dorothy C., Kipkoech, J., Medley, Graham, Cane, Patricia, Nokes, D. James, Kibirige, N.   +7 more
core   +1 more source

Preparing for pandemics: a systematic review of pandemic influenza clinical management guidelines

BMC Medicine, 2022
Background The COVID-19 pandemic has highlighted the importance of evidence-based clinical decision-making. Clinical management guidelines (CMGs) may help reduce morbidity and mortality by improving the quality of clinical decisions.
Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W. Horby, Louise Sigfrid   +16 more
doaj   +1 more source

The incidence and clinical burden of respiratory syncytial virus disease identified through hospital outpatient presentations in Kenyan children [PDF]

, 2012
There is little information that describe the burden of respiratory syncytial virus (RSV) associated disease in the tropical African outpatient setting. Methods We studied a systematic sample of children aged
Bett, Ann, Okiro Emelda A., D James Nokes, Ann Bett, Bett Ann, Emelda A Okiro, Ngama Mwanajuma, Nokes D. James, Nokes, D. James, Mwanajuma Ngama, Ngama, Mwanajuma, Okiro, Emelda A.   +11 more
core   +1 more source

The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus

Nature Communications, 2020
Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary ...
Takanori Furukawa, Norman van Rhijn, Marcin Fraczek, Fabio Gsaller, Emma Davies, Paul Carr, Sara Gago, Rachael Fortune-Grant, Sayema Rahman, Jane Mabey Gilsenan, Emma Houlder, Caitlin H. Kowalski, Shriya Raj, Sanjoy Paul, Peter Cook, Josie E. Parker, Steve Kelly, Robert A. Cramer, Jean-Paul Latgé, Scott Moye-Rowley, Elaine Bignell, Paul Bowyer, Michael J. Bromley   +22 more
doaj   +1 more source

Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort [PDF]

, 2013
The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in ...
G.F. Medley, C.J. Sande, Sande, Charles J., P.A. Cane, Medley, Graham, Cane, Patricia, Nokes, D. James, Mutunga, M. N., M.N. Mutunga, E.A. Okiro, D.J. Nokes, Okiro, Emelda A.   +11 more
core   +1 more source

Severe lower respiratory tract infection in early infancy and pneumonia hospitalizations among children, Kenya. [PDF]

, 2013
Severe lower respiratory tract infection (LRTI) in infants caused by respiratory syncytial virus (RSV) has been associated with later pneumonia hospitalization among children.
Eric O. Ohuma, Nokes, D. James, Nokes, DJ, Ngama, Mwanajuma, Ngama, M, Patrick Kiio Munywoki, Bauni, E, Scott, J Anthony G, Ohuma, Eric O., Munywoki, Patrick Kiio, Scott, John, Ohuma, EO, J. Anthony G. Scott, Munywoki, PK, Bauni, Evasius, Mwanajuma Ngama, Scott, J. Anthony G., Nokes, D James, Ohuma, Eric O, Evasius Bauni, D. James Nokes   +20 more
core   +1 more source

Lung colonization by Aspergillus fumigatus is controlled by ZNF77

Nature Communications, 2018
Aspergillus fumigatus regularly colonises the lungs but in the context of respiratory disease can be associated with increased pathology. Here the authors show mutations in ZNF77 result in altered bronchial epithelial characteristics and enhanced fungal ...
Sara Gago, Nicola L. D. Overton, Nagwa Ben-Ghazzi, Lilyann Novak-Frazer, Nick D. Read, David W. Denning, Paul Bowyer   +6 more
doaj   +1 more source

Variable DNA methylation of aging-related genes is associated with male COPD

Respiratory Research, 2019
Background Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age.
Xizi Du, Lin Yuan, Mengping Wu, Meichao Men, Ruoxi He, Leyuan Wang, Shuangyan Wu, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Chengping Hu, Ling Qin, Chi Liu   +13 more
doaj   +1 more source

Risk factors for respiratory syncytial virus bronchiolitis hospital admission in New Zealand. [PDF]

, 2008
This study assessed risk factors for respiratory syncytial virus (RSV) hospitalization and disease severity in Wellington, New Zealand. During the southern hemisphere winter months of 2003--2005, 230 infants aged < 24 months hospitalized with ...
Rich, F. J., Pearce, N., Cheng, S., Cunningham, CW, Kirman, JR, Cunningham, C., Pierce, N., Cheng, S, Pearce, N, Grimwood, K., Cohet, C., Wood, C, Redshaw, N, Rich, F., Wood, C., Cunningham, C. W., Kirman, J., Grimwood, K, Rich, FJ, Cohet, C, Redshaw, N., Kirman, J. R.   +21 more
core   +1 more source