Results 1 to 10 of about 248,805 (183)

A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge [PDF]

Journal of Biomedical Science, 2023
Background Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in children.
Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan, Bor-Luen Chiang   +9 more
doaj   +5 more sources

NAD+ Suppresses EV-D68 Infection by Enhancing Anti-Viral Effect of SIRT1 [PDF]

Viruses
Enterovirus 68 (EV-D68) is a non-enveloped virus with a positive-sense single-stranded RNA genome that causes respiratory diseases and acute flaccid myelitis, posing significant threats to human health.
Yue Wang, Haiyu Li, Xia Huang, Yan Huang, Mingqi Lv, Hong Tang, Xinyue Han, Juntong Liu, Yan Liang, Guangchao Zang, Nan Lu, Guangyuan Zhang   +11 more
doaj   +5 more sources

Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles [PDF]

Frontiers in Microbiology, 2018
Enterovirus D68 (EV-D68) has emerged as a significant respiratory pathogen that can cause severe respiratory disease and acute neurologic disease. At present, there are no approved antiviral agents or vaccines for EV-D68.
Dongyin Wang, Dongyin Wang, Haoran Guo, Junliang Chang, Junliang Chang, Dong Wang, Dong Wang, Bin Liu, Pujun Gao, Wei Wei   +9 more
doaj   +6 more sources

EV-D68 neurological disease: tipping the scales toward immunopathogenesis. [PDF]

J Clin Invest
Over the last decade, there have been multiple outbreaks of enterovirus D68 (EV-D68) disease and associated cases of acute flaccid myelitis (AFM). The underlying cause of EV-D68-induced AFM is contentious; whether spinal cord motor neurons are damaged by direct viral infection, infiltration of immune cells, or a combination of both is not clear.
Krug PW.
europepmc   +5 more sources

Structural insights from vaccine candidates for EV-D68. [PDF]

Commun Biol
Enterovirus D68 (EV-D68), a member of the Picornaviridae family, causes respiratory illness and can lead to acute flaccid myelitis in children. No specific treatment or vaccine is available. Here, we determine cryo-EM structures of EV-D68 virus-like particles (VLPs), inactivated virus particles (InVPs), and altered virus particles (A-particles) from B3
Cheng J, Krug PW, Lei H, Moss DL, Lang ZC, Morton AJ, Shen CH, Pletnev S, Huang RK, Pierson TC, Zhou T, Ruckwardt TJ, Kwong PD.   +12 more
europepmc   +5 more sources

Emerging Therapeutics in the Fight Against EV-D68: A Review of Current Strategies. [PDF]

Influenza Other Respir Viruses
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods.
Kalam N, Balasubramaniam VRMT.
europepmc   +4 more sources

A cross-sectional seroepidemiology study of EV-D68 in China [PDF]

Emerging Microbes and Infections, 2018
Enterovirus 68 (EV-D68) is associated with respiratory diseases, such as acute upper respiratory tract infections (URTIs), lower respiratory tract infections (LRTIs), pneumonia, neurological diseases, and acute flaccid myelitis (AFM).
Shiyang Sun, Fan Gao, Yalin Hu, Lianlian Bian, Xing Wu, Yao Su, Ruixiao Du, Ying Fu, Fengcai Zhu, Qunying Mao, Zhenglun Liang   +10 more
doaj   +4 more sources

Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data. [PDF]

Elife, 2023
Abstract The factors leading to the global emergence of enterovirus D68 (EV-D68) in 2014 as a cause of acute flaccid myelitis (AFM) in children are unknown. To investigate potential changes in virus transmissibility or population susceptibility, we measured the seroprevalence of EV-D68-specific neutralising antibodies in serum samples ...
Pons-Salort M, Lambert B, Kamau E, Pebody R, Harvala H, Simmonds P, Grassly NC.   +6 more
europepmc   +8 more sources

EV-D68 exploits clathrin-mediated endocytosis and compensatory macropinocytosis for cellular entry [PDF]

Journal of Virology
Despite growing health concerns about enterovirus D68 (EV-D68), its cellular entry mechanisms remain incompletely understood. In this study, we investigated the endocytic pathways exploited by the sialic acid-dependent EV-D68 TW-02795-2014 strain using ...
Chia-Yi Lin, Wen-Fang Tang, Kuang-Jing Huang, Li-Ting Wang, Jie-Yun Cai, Cheng-Hsun Chiu, Jim-Tong Horng   +6 more
doaj   +3 more sources

SNAP23 is essential for germination of EV-D68 replication organelles. [PDF]

Virology, 2023
Picornaviruses rearrange host cell membranes to facilitate their own replication. Here we investigate the Qbc SNARE, SNAP23, which is found at the plasma membrane and plays roles in exocytosis. We found that knockdown of SNAP23 expression inhibits virus replication but not release from cells.
Miller K, Wagner MA, Jassey A, Jackson WT.   +3 more
europepmc   +3 more sources