Results 1 to 10 of about 317,847 (188)

A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge [PDF]

Journal of Biomedical Science, 2023
Background Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in children.
Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan, Bor-Luen Chiang   +9 more
doaj   +5 more sources

NAD+ Suppresses EV-D68 Infection by Enhancing Anti-Viral Effect of SIRT1 [PDF]

Viruses
Enterovirus 68 (EV-D68) is a non-enveloped virus with a positive-sense single-stranded RNA genome that causes respiratory diseases and acute flaccid myelitis, posing significant threats to human health.
Yue Wang, Haiyu Li, Xia Huang, Yan Huang, Mingqi Lv, Hong Tang, Xinyue Han, Juntong Liu, Yan Liang, Guangchao Zang, Nan Lu, Guangyuan Zhang   +11 more
doaj   +5 more sources

Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles [PDF]

Frontiers in Microbiology, 2018
Enterovirus D68 (EV-D68) has emerged as a significant respiratory pathogen that can cause severe respiratory disease and acute neurologic disease. At present, there are no approved antiviral agents or vaccines for EV-D68.
Dongyin Wang, Dongyin Wang, Haoran Guo, Junliang Chang, Junliang Chang, Dong Wang, Dong Wang, Bin Liu, Pujun Gao, Wei Wei   +9 more
doaj   +7 more sources

A cross-sectional seroepidemiology study of EV-D68 in China [PDF]

Emerging Microbes and Infections, 2018
Enterovirus 68 (EV-D68) is associated with respiratory diseases, such as acute upper respiratory tract infections (URTIs), lower respiratory tract infections (LRTIs), pneumonia, neurological diseases, and acute flaccid myelitis (AFM).
Shiyang Sun, Fan Gao, Yalin Hu, Lianlian Bian, Xing Wu, Yao Su, Ruixiao Du, Ying Fu, Fengcai Zhu, Qunying Mao, Zhenglun Liang   +10 more
doaj   +4 more sources

EV-D68 exploits clathrin-mediated endocytosis and compensatory macropinocytosis for cellular entry [PDF]

Journal of Virology
Despite growing health concerns about enterovirus D68 (EV-D68), its cellular entry mechanisms remain incompletely understood. In this study, we investigated the endocytic pathways exploited by the sialic acid-dependent EV-D68 TW-02795-2014 strain using ...
Chia-Yi Lin, Wen-Fang Tang, Kuang-Jing Huang, Li-Ting Wang, Jie-Yun Cai, Cheng-Hsun Chiu, Jim-Tong Horng   +6 more
doaj   +3 more sources

Enterovirus D68 Detected in Hospitalized Children With Severe Acute Respiratory Infections in Zambia. [PDF]

Influenza Other Respir Viruses
ABSTRACT Enterovirus D68 (EV‐D68) is a cause of severe acute respiratory infections (SARI) and is associated with acute flaccid paralysis. However, data on EV‐D68 in Africa, where SARI remains a leading cause of morbidity and mortality among children, remain limited.
Ndumba IM, Okamoto M, Simusika P, Imamura T, Monze M, Saito M, Oshitani H.   +6 more
europepmc   +2 more sources

Enterovirus infections in children. [PDF]

Pediatr Investig
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Chen X, Guo L, Lei X, Zhao L, Hei M, Shen J, Yin J, Li F, Deng J, Liu G, Zhang Y, Xie Z.   +11 more
europepmc   +2 more sources

Prospective use of wastewater surveillance for early detection of enterovirus D68 in community outbreaks among children, Niigata City, Japan, 2024 [PDF]

Eurosurveillance
INTRODUCTION Enterovirus D68 (EV-D68) is a re-emerging pathogen that can cause acute respiratory illness in children and difficult to predict outbreaks.
Akihiko Saitoh
doaj   +2 more sources

Molecular and epidemiological study of enterovirus D68 in Taiwan

Journal of Microbiology, Immunology and Infection, 2017
Background/purpose: As an immunofluorescence assay for enterovirus D68 (EV-D68) is not available in the enteroviruses surveillance network in Taiwan, EV-D68 may be the actual pathogen of untypeable enterovirus-suspected isolates.
Yuan-Pin Huang, Tsuey-Li Lin, Ting-Han Lin, Ho-Sheng Wu   +3 more
exaly   +3 more sources

Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021

Viruses, 2022
Infection with enterovirus D68 (EV-D68) has been linked with severe neurological disease such as acute flaccid myelitis (AFM) in recent years. However, active surveillance for EV-D68 is lacking, which makes full assessment of this association difficult ...
Alison Tedcastle, Thomas Wilton, Elaine Pegg, Dimitra Klapsa, Erika Bujaki, Ryan Mate, Martin Fritzsche, Manasi Majumdar, Javier Martin   +8 more
doaj   +1 more source