Results 31 to 40 of about 317,847 (188)

Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA

Emerging Infectious Diseases, 2023
Enterovirus D68 (EV-D68) causes cyclical outbreaks of respiratory disease and acute flaccid myelitis. EV-D68 is primarily transmitted through the respiratory route, but the duration of shedding in the respiratory tract is unknown.
Hai Nguyen-Tran, Careese Thompson, Molly Butler, Kristen R. Miller, Laura Pyle, Sarah Jung, Shannon Rogers, Terry Fei Fan Ng, Janell Routh, Samuel R. Dominguez, Kevin Messacar   +10 more
doaj   +1 more source

Structure and inhibition of EV-D68, a virus that causes respiratory illness in children [PDF]

Science, 2015
Targeting EV-D68, a respiratory virus A recent outbreak of respiratory illness in U.S. children was caused by entorovirus D68 (EV-D68). Enteroviruses also include human pathogens such as human rhinovirus, which causes the common cold, and poliovirus. Most of these viruses are stabilized by a factor that binds in a
Yue, Liu, Ju, Sheng, Andrei, Fokine, Geng, Meng, Woong-Hee, Shin, Feng, Long, Richard J, Kuhn, Daisuke, Kihara, Michael G, Rossmann   +8 more
openaire   +2 more sources

Emergence of divergent enterovirus (EV) D68 sub-clade D1 strains, northern Italy, September to October 2018. [PDF]

Euro Surveill, 2019
An enterovirus D68 (EV-D68) outbreak was recognised at a major tertiary centre and research hospital in Milan and Pavia in the Lombardy region, northern Italy, respectively, between September and October 2018.
Pellegrinelli L, Giardina F, Lunghi G, Uceda Renteria SC, Greco L, Fratini A, Galli C, Piralla A, Binda S, Pariani E, Baldanti F.   +10 more
europepmc   +2 more sources

Genomic analysis of enterovirus D68, including one strain isolated from a child with Wilson's disease in Taiwan

Journal of the Formosan Medical Association, 2019
North America experienced life-threatening outbreaks of enterovirus D68 (EV-D68) in 2014. We retrospectively detected EV-D68 from a child with Wilson's disease in 2008 in Taiwan. After comparing this EV-D68/Taiwan/2008 strain with EV-D68 genomes obtained
Yeh-Sheng Chien, Shu-Ting Luo, Kuo-Chien Tsao, Ying-Hsiang Wang, Tzou-Yien Lin, Yhu-Chering Huang, Min-Shi Lee   +6 more
doaj   +1 more source

CD74 Interacts with Proteins of Enterovirus D68 To Inhibit Virus Replication

Microbiology Spectrum, 2023
Enterovirus D68 (EV-D68) is a member of the species Enterovirus D in the genus Enterovirus of the family Picornaviridae. As an emerging non-polio enterovirus, EV-D68 is widely spread all over the world and causes severe neurological and respiratory ...
Zichun Xiang, Zhongqin Tian, Guanying Wang, Lulu Liu, Kailin Li, Wenjing Wang, Xiaobo Lei, Lili Ren, Jianwei Wang   +8 more
doaj   +1 more source

Enterovirus D68 in Hospitalized Children: Sequence Variation, Viral Loads and Clinical Outcomes.

PLoS ONE, 2016
BackgroundAn outbreak of enterovirus D68 (EV-D68) caused severe respiratory illness in 2014. The disease spectrum of EV-D68 infections in children with underlying medical conditions other than asthma, the role of EV-D68 loads on clinical illness, and the
Katherine Moyer, Huanyu Wang, Douglas Salamon, Amy Leber, Asuncion Mejias   +4 more
doaj   +1 more source

EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA. [PDF]

PLoS Pathog
Enterovirus D68 (EV-D68) is an emerging pathogen associated with severe respiratory diseases and neurological complications, such as acute flaccid myelitis.
Tan R, Zhang Y, Huang M, Chen H, Liu Z, Wang Z, Li X, Wang T, Wang Z.   +8 more
europepmc   +2 more sources

Serial viral passage and reverse genetics protocol for identifying the antiviral drug targets of EV-D68 antivirals. [PDF]

STAR Protoc
Identifying antiviral targets and mechanisms is crucial for drug discovery. Here, we present a protocol to select EV-D68 variants resistant to Jun6504 by combining serial passage and reverse genetics. We describe steps for viral serial passage, sequencing, and viral genome mutagenesis.
Tan H, Li K, Wang J.
europepmc   +4 more sources

Acute flaccid myelitis associated with enterovirus D68 in a non-epidemic setting

IDCases, 2019
Acute flaccid myelitis (AFM) is a recently defined clinical disease accompanied by the national outbreak of enterovirus D68 (EV-D68) in the United States during the late summer/fall of 2014; 258 cases of EV-D68 and 59 cases of AFM were reported in Japan ...
Kazuki Hatayama, Shinichiro Goto, Masato Yashiro, Harushi Mori, Tsuguto Fujimoto, Nozomu Hanaoka, Keiko Tanaka-Taya, Tomoka Zuzan, Masaru Inoue   +8 more
doaj   +1 more source

SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis. [PDF]

J Virol
Pyroptosis plays a crucial role in the pathogenesis of coronavirus disease 2019, and comprehending its function may facilitate the development of novel therapeutic strategies. This study aims to explore how viral-encoded proteases modulate pyroptosis.
Shen S, Guo H, Li Y, Zhang L, Tang Y, Li H, Li X, Wang P-H, Yu X-F, Wei W.   +9 more
europepmc   +3 more sources