Results 11 to 20 of about 317,847 (188)

EV-D68 neurological disease: tipping the scales toward immunopathogenesis. [PDF]

J Clin Invest
Over the last decade, there have been multiple outbreaks of enterovirus D68 (EV-D68) disease and associated cases of acute flaccid myelitis (AFM). The underlying cause of EV-D68–induced AFM is contentious; whether spinal cord motor neurons are damaged by direct viral infection, infiltration of immune cells, or a combination of both
Krug PW.
europepmc   +5 more sources

Structural insights from vaccine candidates for EV-D68. [PDF]

Commun Biol
Enterovirus D68 (EV-D68), a member of the Picornaviridae family, causes respiratory illness and can lead to acute flaccid myelitis in children. No specific treatment or vaccine is available. Here, we determine cryo-EM structures of EV-D68 virus-like particles (VLPs), inactivated virus particles (InVPs), and altered virus particles (A-particles) from B3
Cheng J, Krug PW, Lei H, Moss DL, Lang ZC, Morton AJ, Shen CH, Pletnev S, Huang RK, Pierson TC, Zhou T, Ruckwardt TJ, Kwong PD.   +12 more
europepmc   +5 more sources

Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68). [PDF]

J Med Chem, 2019
Enterovirus D68 (EV-D68) is an atypical nonpolio enterovirus that mainly infects the respiratory system of humans, leading to moderate-to-severe respiratory diseases. In rare cases, EV-D68 can spread to the central nervous system and cause paralysis in infected patients, especially young children and immunocompromised individuals. There is currently no
Musharrafieh R, Zhang J, Tuohy P, Kitamura N, Bellampalli SS, Hu Y, Khanna R, Wang J.   +7 more
europepmc   +5 more sources

Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data. [PDF]

Elife, 2023
Abstract The factors leading to the global emergence of enterovirus D68 (EV-D68) in 2014 as a cause of acute flaccid myelitis (AFM) in children are unknown. To investigate potential changes in virus transmissibility or population susceptibility, we measured the seroprevalence of EV-D68-specific neutralising antibodies in serum samples ...
Pons-Salort M, Lambert B, Kamau E, Pebody R, Harvala H, Simmonds P, Grassly NC.   +6 more
europepmc   +8 more sources

In vitro and in vivo models for the study of EV-D68 infection [PDF]

Pathology, 2023
Enterovirus D68 (EV-D68) is one of hundreds of non-polio enteroviruses that typically cause cold-like respiratory illness. The first EV-D68 outbreak in the United States in 2014 aroused widespread concern among the public and health authorities.
Yuan Teng Hooi, Vinod R.M.T. Balasubramaniam   +1 more
openaire   +3 more sources

Prevalence and clinical presentation of EV-D68 infections in Kansas City children during the 2022 season

Diagnostic Microbiology and Infectious Disease, 2023
Seasonal EV-D68 infections can strain medical care resources due to increased pediatric hospitalizations for respiratory illness. In this study, we examine Kansas City's 2022 EV-D68 season. Rhinovirus/enterovirus (RV/EV) positive respiratory specimens from standard of care testing were salvaged and tested by EV-D68 specific PCR. Of the 1412 respiratory
Stephanie Gummersheimer, Amanda Hayes, Christopher Harrison, Brian Lee, Jennifer Schuster, Minati Dhar, Anjana Sasidharan, Dithi Banerjee, Rangaraj Selvarangan   +8 more
core   +4 more sources

Enterovirus D68 – The New Polio? [PDF]

Frontiers in Microbiology, 2018
Enterovirus D68 (EV-D68) has emerged over the recent years, with large outbreaks worldwide. Increased occurrence has coincided with improved clinical awareness and surveillance of non-polio enteroviruses.
Hayley Cassidy, Randy Poelman, Marjolein Knoester, Coretta C. Van Leer-Buter, Hubert G. M. Niesters   +4 more
doaj   +3 more sources

SNAP23 is essential for germination of EV-D68 replication organelles. [PDF]

Virology, 2023
Picornaviruses rearrange host cell membranes to facilitate their own replication. Here we investigate the Qbc SNARE, SNAP23, which is found at the plasma membrane and plays roles in exocytosis. We found that knockdown of SNAP23 expression inhibits virus replication but not release from cells.
Miller K, Wagner MA, Jassey A, Jackson WT.   +3 more
europepmc   +3 more sources

Additional file 1 of A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge

, 2023
Additional file 1: Figure S1. EV-D68- and EV-A71-specific IgG1 and IgG2c responses in sera of mice. Figure S2. Comparative assessment of the virulence of diverse enterovirus strains, infection routes, and inoculation titres in ICR mice.
Lin, Yu-Li, Cheng, Pei-Yun, Chin, Chiao-Li, Chuang, Kuan-Ting, Lin, Jing-Yi, Chang, Ning, Pan, Chun-Kei, Lin, Cheng-Sheng, Pan, Siao-Cian, Chiang, Bor-Luen   +9 more
openaire   +2 more sources

Emerging Therapeutics in the Fight Against EV-D68: A Review of Current Strategies. [PDF]

Influenza Other Respir Viruses
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods.
Kalam N, Balasubramaniam VRMT.
europepmc   +3 more sources