Results 11 to 20 of about 248,805 (183)

Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68). [PDF]

J Med Chem, 2019
Enterovirus D68 (EV-D68) is an atypical nonpolio enterovirus that mainly infects the respiratory system of humans, leading to moderate-to-severe respiratory diseases. In rare cases, EV-D68 can spread to the central nervous system and cause paralysis in infected patients, especially young children and immunocompromised individuals. There is currently no
Musharrafieh R, Zhang J, Tuohy P, Kitamura N, Bellampalli SS, Hu Y, Khanna R, Wang J.   +7 more
europepmc   +5 more sources

Enterovirus D68 – The New Polio? [PDF]

Frontiers in Microbiology, 2018
Enterovirus D68 (EV-D68) has emerged over the recent years, with large outbreaks worldwide. Increased occurrence has coincided with improved clinical awareness and surveillance of non-polio enteroviruses.
Hayley Cassidy, Randy Poelman, Coretta C Van Leer-Buter   +2 more
exaly   +4 more sources

The association between acute flaccid myelitis (AFM) and Enterovirus D68 (EV-D68) - what is the evidence for causation? [PDF]

Euro Surveill, 2018
Background Enterovirus D68 (EV-D68) has historically been a sporadic disease, causing occasional small outbreaks of generally mild infection. In recent years, there has been evidence of an increase in EV-D68 infections globally.
Dyda A, Stelzer-Braid S, Adam D, Chughtai AA, MacIntyre CR.   +4 more
europepmc   +9 more sources

Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy

Journal of Clinical Virology, 2018
In recent years, several outbreaks due to Enterovirus D-68 (EV-D68) have been reported, and it was confirmed that the virus can cause upper and lower respiratory tract diseases and be associated with the development of neurological problems.The main aim of this research was to study the genetic characteristics of EV-D68 strains that were circulating in
Antonio Piralla, Alessia Girello, Federica Giardina   +2 more
exaly   +5 more sources

Enterovirus D68 Infection [PDF]

Viruses, 2015
First described in 1962 in children hospitalized for pneumonia and bronchiolitis, the Enterovirus D68 (EV-D68) is an emergent viral pathogen. Since its discovery, during the long period of surveillance up to 2005, EV-D68 was reported only as a cause of ...
Susanna Esposito, Samantha Bosis, Hubert G M Niesters   +2 more
exaly   +4 more sources

Molecular and epidemiological study of enterovirus D68 in Taiwan

Journal of Microbiology, Immunology and Infection, 2017
Background/purpose: As an immunofluorescence assay for enterovirus D68 (EV-D68) is not available in the enteroviruses surveillance network in Taiwan, EV-D68 may be the actual pathogen of untypeable enterovirus-suspected isolates.
Tsuey-Li Lin, Ho-Sheng Wu
exaly   +4 more sources

In vitro and in vivo models for the study of EV-D68 infection [PDF]

Pathology, 2023
Enterovirus D68 (EV-D68) is one of hundreds of non-polio enteroviruses that typically cause cold-like respiratory illness. The first EV-D68 outbreak in the United States in 2014 aroused widespread concern among the public and health authorities.
Yuan Teng Hooi, Vinod R.M.T. Balasubramaniam   +1 more
openaire   +3 more sources

Altered cell function and increased replication of rhinoviruses and EV-D68 in airway epithelia of asthma patients. [PDF]

Front Microbiol, 2023
IntroductionRhinovirus (RV) infections constitute one of the main triggers of asthma exacerbations and an important burden in pediatric yard. However, the mechanisms underlying this association remain poorly understood.MethodsIn the present study, we compared infections of in vitro reconstituted airway epithelia originating from asthmatic versus ...
Essaidi-Laziosi M, Royston L, Boda B, Pérez-Rodriguez FJ, Piuz I, Hulo N, Kaiser L, Clément S, Huang S, Constant S, Tapparel C.   +10 more
europepmc   +4 more sources

STING Orchestrates EV-D68 Replication and Immunometabolism within Viral-Induced Replication Organelles. [PDF]

Viruses
Some respiratory viruses, such as Human Rhinovirus, SARS-CoV-2, and Enterovirus D-68 (EV-D68), share the feature of hijacking host lipids in order to generate specialised replication organelles (ROs) with unique lipid compositions to enable viral replication.
Triantafilou K, Szomolay B, Shepherd MW, Ramanjulu J, Triantafilou M.   +4 more
europepmc   +4 more sources

Pharmacological activation of TLR7 exerts inhibition on the replication of EV-D68 in respiratory cells. [PDF]

J Virol
ABSTRACT The globally reemerging respiratory pathogen enterovirus D68 (EV-D68) is implicated in outbreaks of severe respiratory illness and associated with acute flaccid myelitis. However, there remains a lack of effective treatments for EV-D68 infection.
Li H, Huang Y, Yang Q, Zhang Z, Shen S, Guo H, Wei W.   +6 more
europepmc   +3 more sources