Results 21 to 30 of about 248,805 (183)

Prospective use of wastewater surveillance for early detection of enterovirus D68 in community outbreaks among children, Niigata City, Japan, 2024 [PDF]

Eurosurveillance
INTRODUCTION Enterovirus D68 (EV-D68) is a re-emerging pathogen that can cause acute respiratory illness in children and difficult to predict outbreaks.
Akihiko Saitoh
doaj   +2 more sources

Serial viral passage and reverse genetics protocol for identifying the antiviral drug targets of EV-D68 antivirals. [PDF]

STAR Protoc
Identifying antiviral targets and mechanisms is crucial for drug discovery. Here, we present a protocol to select EV-D68 variants resistant to Jun6504 by combining serial passage and reverse genetics. We describe steps for viral serial passage, sequencing, and viral genome mutagenesis.
Tan H, Li K, Wang J.
europepmc   +4 more sources

SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis. [PDF]

J Virol
Pyroptosis plays a crucial role in the pathogenesis of coronavirus disease 2019, and comprehending its function may facilitate the development of novel therapeutic strategies. This study aims to explore how viral-encoded proteases modulate pyroptosis.
Shen S, Guo H, Li Y, Zhang L, Tang Y, Li H, Li X, Wang P-H, Yu X-F, Wei W.   +9 more
europepmc   +3 more sources

Respiratory enterovirus D68: virology, clinical surveillance, host-pathogen interactions, and therapeutic prospects [PDF]

Frontiers in Cellular and Infection Microbiology
Enterovirus D68 (EV-D68), a unique enterovirus resembling human rhinoviruses, was long considered to cause only sporadic outbreaks of mild, self-limiting respiratory infections mainly in children.
Yanshan Gui, Bing Han, Jialong Wei, Danlei Sun, Laixian Zhou, Shuchen Yuan, Wenzhan Xie, Hui Feng   +7 more
doaj   +2 more sources

Rational design and in vivo validation of capsid inhibitors for enterovirus D68 [PDF]

Nature Communications
Enterovirus D68 (EV-D68) is a respiratory virus that causes neurological complications such as acute flaccid myelitis (AFM) and death in children. No vaccine or antiviral is available for EV-D68.
Kan Li, Michael J. Rudy, Thomas Klose, Haozhou Tan, Xiangmeng Wu, Hiwot A. Demssie, Jacqueline S. Anderson, Prakash Jadhav, Qing-Yu Zhang, Penny Clarke, Richard J. Kuhn, Kenneth L. Tyler, Jun Wang   +12 more
doaj   +2 more sources

Enterovirus-D68—Neglected Pathogen in Acute Respiratory Infections: Insights from Croatia [PDF]

Pathogens
Background: Enterovirus-D68 (EV-D68) was long underreported, with only sporadic cases of respiratory disease worldwide until 2014, when numerous countries experienced significant outbreaks of EV-D68.
Zeljka Hruskar, Lucija Skara Abramovic, Ivana Ferencak, Dragan Juric, Josipa Lozic, Anita Juric, Bojana Bocka, Marin Bajek, Mirela Josipovic, Viktor Bekic, Irena Tabain   +10 more
doaj   +2 more sources

Epidemiology of Enterovirus D68 in Ontario. [PDF]

PLoS ONE, 2015
In August 2014, children's hospitals in Kansas City, Missouri and Chicago, Illinois notified the Centers for Disease Control and Prevention (CDC) about increased numbers of pediatric patients hospitalized with severe respiratory illness (SRI).
Adriana Peci, Anne-Luise Winter, Bryna Warshawsky, Tim F Booth, AliReza Eshaghi, Aimin Li, Stephen Perusini, Romy Olsha, Alex Marchand-Austin, Erik Kristjanson, Jonathan B Gubbay   +10 more
doaj   +2 more sources

Additional file 1 of A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge

, 2023
Additional file 1: Figure S1. EV-D68- and EV-A71-specific IgG1 and IgG2c responses in sera of mice. Figure S2. Comparative assessment of the virulence of diverse enterovirus strains, infection routes, and inoculation titres in ICR mice.
Lin, Yu-Li, Cheng, Pei-Yun, Chin, Chiao-Li, Chuang, Kuan-Ting, Lin, Jing-Yi, Chang, Ning, Pan, Chun-Kei, Lin, Cheng-Sheng, Pan, Siao-Cian, Chiang, Bor-Luen   +9 more
openaire   +2 more sources

Sensitive and Accurate Quantification of Enterovirus-D68 (EV-D68) Viral Loads Using Droplet Digital PCR (ddPCR). [PDF]

Microorganisms
Enterovirus-D68 (EV-D68) is a reemerging virus that has been associated with numerous outbreaks in children in the past 10 years. Most assays examining viral infection kinetics have relied on the use of quantitative RT-PCR (qRT-PCR) assays as an assay of
Grizer CS, Li Z, Mattapallil JJ.
europepmc   +2 more sources

Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021

Viruses, 2022
Infection with enterovirus D68 (EV-D68) has been linked with severe neurological disease such as acute flaccid myelitis (AFM) in recent years. However, active surveillance for EV-D68 is lacking, which makes full assessment of this association difficult ...
Alison Tedcastle, Thomas Wilton, Elaine Pegg, Dimitra Klapsa, Erika Bujaki, Ryan Mate, Martin Fritzsche, Manasi Majumdar, Javier Martin   +8 more
doaj   +1 more source