Results 21 to 30 of about 317,847 (188)

Altered cell function and increased replication of rhinoviruses and EV-D68 in airway epithelia of asthma patients. [PDF]

Front Microbiol, 2023
IntroductionRhinovirus (RV) infections constitute one of the main triggers of asthma exacerbations and an important burden in pediatric yard. However, the mechanisms underlying this association remain poorly understood.MethodsIn the present study, we compared infections of in vitro reconstituted airway epithelia originating from asthmatic versus ...
Essaidi-Laziosi M, Royston L, Boda B, Pérez-Rodriguez FJ, Piuz I, Hulo N, Kaiser L, Clément S, Huang S, Constant S, Tapparel C.   +10 more
europepmc   +4 more sources

Sensitive and Accurate Quantification of Enterovirus-D68 (EV-D68) Viral Loads Using Droplet Digital PCR (ddPCR). [PDF]

Microorganisms
Enterovirus-D68 (EV-D68) is a reemerging virus that has been associated with numerous outbreaks in children in the past 10 years. Most assays examining viral infection kinetics have relied on the use of quantitative RT-PCR (qRT-PCR) assays as an assay of
Grizer CS, Li Z, Mattapallil JJ.
europepmc   +2 more sources

Zinc Influx Restricts Enterovirus D68 Replication

Frontiers in Microbiology, 2021
Enterovirus D68 (EV-D68) is a respiratory viral pathogen that causes severe respiratory diseases and neurologic manifestations. Since the 2014 outbreak, EV-D68 has been reported to cause severe complications worldwide.
Shunan Liu, Xia Cao, Haoran Guo, Wei Wei
doaj   +1 more source

Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan

BMC Infectious Diseases, 2023
Background Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to ...
Kazuhiro Yoshida, Masamichi Muramatsu, Hiroyuki Shimizu   +2 more
doaj   +1 more source

STING Orchestrates EV-D68 Replication and Immunometabolism within Viral-Induced Replication Organelles. [PDF]

Viruses
Some respiratory viruses, such as Human Rhinovirus, SARS-CoV-2, and Enterovirus D-68 (EV-D68), share the feature of hijacking host lipids in order to generate specialised replication organelles (ROs) with unique lipid compositions to enable viral replication.
Triantafilou K, Szomolay B, Shepherd MW, Ramanjulu J, Triantafilou M.   +4 more
europepmc   +4 more sources

Pterostilbene, an active constituent of blueberries, enhances innate immune activation and restricts enterovirus D68 infection

Frontiers in Immunology, 2023
Enterovirus D68 (EV-D68) is a globally re-emerging respiratory pathogen implicated in outbreaks of severe respiratory illnesses and associated with acute flaccid myelitis. However, effective vaccines or treatments for EV-D68 infections remain scarce.
Qingran Yang, Huili Li, Zhaoxue Li, Jiaxin Yang, Zhe Zhang, Lili Zhang, Haoran Guo, Wei Wei, Wei Wei   +8 more
doaj   +1 more source

Pharmacological activation of TLR7 exerts inhibition on the replication of EV-D68 in respiratory cells. [PDF]

J Virol
ABSTRACT The globally reemerging respiratory pathogen enterovirus D68 (EV-D68) is implicated in outbreaks of severe respiratory illness and associated with acute flaccid myelitis. However, there remains a lack of effective treatments for EV-D68 infection.
Li H, Huang Y, Yang Q, Zhang Z, Shen S, Guo H, Wei W.   +6 more
europepmc   +3 more sources

Enterovirus (EV) D68 TaqMan 2018 (EV-D68-TM2018) v1 [PDF]

, 2018
This protocol aims to amplify enterovirus (EV) D68 viruses and not other viruses. This protocol is modified from a previously published method cited below. Details of the modification are included in the method. The oligonucleotides target the 5'UTR noncoding region. This is a qualitative test for investigating EV-D68 infection of humans.
Ian M Mackay, Judy A Northill
openaire   +1 more source

Enterovirus (EV) D68 real-time RT-PCR (EV-D68-TM2018) v2 [PDF]

, 2019
This protocol aims to amplify enterovirus (EV) D68 viruses but not other viruses. This protocol is modified from a previously published method cited below. Details of the modification are included in the method. The oligonucleotides target the 5'UTR noncoding region. This is a qualitative test for investigating EV-D68 infection of humans.
Ian M Mackay, Judy A Northill
openaire   +1 more source

Apical-out airway organoids are susceptible to infection with EV-D68

, 2023
 (A) Representative brightfield images showing the cytopathologic effect of EV-D68 infection over 48 h. Infected Ap-O AO organoids disintegrate to single cells over the course of the infection (scale bars = 300 μm).
Georgios Stroulios (12536191)
core   +1 more source