Results 121 to 130 of about 3,381,515 (303)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

The Dunkl convolution operators and multipoint de la Vallee–Poussin problem

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2013
The Dunkl operator as an object of mathematical physics is considered, we study the kernel and the surjectivity of Dunkl convolution operators in the space of entire functions and the space of entire functions of exponential type.
Karina Raisovna Zabirova   +1 more
doaj   +1 more source

Factorization of entire solutions of some difference equations [PDF]

open access: yesProceedings of the Japan Academy, Series A, Mathematical Sciences, 1984
Let P(w) be a polynomial and \(\lambda\) a number such that \(\lambda =P(\lambda)\), \(P'(\lambda)=1\) and \(P(w)=\lambda +(w-\lambda)+A_ m(w- \lambda)^{m+1}+...,\) (m\(\geq 1)\) then the difference equation \((1)\quad y(x+1)=P(y(x))\) possesses an entire solution \(\phi_{\lambda}(x).\) The author proves several theorems concerning entire solutions of (
openaire   +2 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Entire Solutions of Nonhomogeneous Linear Differential Equations

open access: yesJournal of Mathematical Analysis and Applications, 1999
A general theorem concerning the existence of entire solutions of a type of second-order nonhomogeneous linear differential equations is established provided that its coefficients and forcing function are themselves entire functions. The proof of this theorem involves obtaining solutions to a subsidiary equation involving a change of scale of the ...
openaire   +3 more sources

Protein kinase FAM20C—when subcellular localization matters

open access: yesFEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

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