Results 121 to 130 of about 3,462,281 (263)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Radial solutions of singular nonlinear biharmonic equations and applications to conformal geometry

open access: yesElectronic Journal of Differential Equations, 2003
Positive entire solutions of the singular biharmonic equation $Delta^2 u + u^{-q}=0$ in $mathbb{R}^n$ with $q>1$ and $ngeq 3$ are considered. We prove that there are infinitely many radial entire solutions with different growth rates close to quadratic ...
P. J. McKenna, Wolfgang Reichel
doaj  

On a long standing conjecture: positive Liouville Theorem for hypoelliptic Ornstein-Uhlenbeck operators

open access: yesBruno Pini Mathematical Analysis Seminar
Let $\mathcal{L}$ be the hypoelliptic Ornstein-Uhlenbeck operator associated with the pair of matrices (A,B). In 2004, Priola and Zabczyk proved the following Liouville-type theorem: every bounded entire solution of $\mathcal{L}u=0$ is constant if and ...
Alessia E. Kogoj   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Entire solutions for a mono-stable delay population model in a 2D lattice strip

open access: yesElectronic Journal of Differential Equations, 2014
This article concerns the entire solutions of a mono-stable age-structured population model in a 2D lattice strip. In a previous publication, we established the existence of entire solutions related to traveling wave solutions with speeds larger than ...
Hai-Qin Zhao, San-Yang Liu
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Existence of entire solutions for non-local delayed lattice differential equations

open access: yesElectronic Journal of Differential Equations, 2013
In this article we study entire solutions for a non-local delayed lattice differential equation with monostable nonlinearity. First, based on a concavity assumption of the birth function, we establish a comparison theorem.
Shi-Liang Wu, San-Yang Liu
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

ENTIRE SOLUTIONS OF HESSIAN EQUATIONS

open access: yes, 2009
We study in this thesis the existence and uniqueness of entire solutions, in appropriate weighted Hölder spaces, of elliptic Hessian equations in Rn and Cn, with rotational invariance.
openaire   +1 more source

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