Results 141 to 150 of about 73,004 (270)

Increased levels of GFAP and purinergic P2X7 receptor in Alzheimer’s disease brain are associated with Aβ, tau pathologies and synaptic loss

Alzheimer’s Research & Therapy
Astrogliosis plays an important role in Alzheimer’s disease(AD). We characterized glial fibrillary acidic protein(GFAP) and purinergic P2X7 receptor(P2X7R) alterations in AD and their associations with amyloid-β levels, tau pathology and synaptic density.
Cinzia A. Maschio, Oscar Moreno, Junlong Wang, Upasana Maheshwari, Annika Keller, Uwe Konietzko, Daniel Razansky, Agneta Nordberg, Axel Rominger, Christoph Hock, Jordi Llop, Roger M. Nitsch, Ruiqing Ni   +12 more
doaj   +1 more source

Quantitative investigations on the human entorhinal area [PDF]

, 1994
Bethke, B., Bohl, J., Eisenmenger, Wolfgang, Götz, M., Heinsen, H., Henn, R., Lockemann, U., Püschel, K.   +7 more
core   +1 more source

Selective reduction of KCNA4 in vulnerable glutamatergic–serotonin neurons of the dorsal raphe nucleus in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Our previous studies demonstrate that htau mice recapitulate many of the neuropsychiatric features of early Alzheimer's disease (AD), and that the dorsal raphe nucleus (DRN) contains distinct subregions. Herein, we investigate the vulnerability of the centromedial DRN to pathologically phosphorylated tau (p‐tau), a region composed
Louis J. Kolling, Nagalakshmi Balasubramanian, Shafa Ismail, Alexander J. Feller, Jessica Marie Hunter Alberhasky, Ruixiang Wang, Luke Jennings, Marco Hefti, Catherine Anne Marcinkiewcz   +8 more
wiley   +1 more source

Correlation of the Changes of Gray Matter Volume with Aβ Deposition and Learning and Memory Abilities in APP/PS1 Mice at Different Periods

康复学报, 2020
Objective:To analyze the correlation in the changes of cerebral gray matter volume and the ability of memory learning, and the deposition of β-amyloid protein (Aβ) in related brain regions of Alzheimer's disease (AD) double-transgenic APP/PS1 model mice,
Yuhao ZHANG, Hao JIN, Xiufeng ZHANG, Shengxiang LIANG, Weilin LIU, Jing TAO, Lidian CHEN   +6 more
doaj  

Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The 2025 Leon Thal Summit convened an international panel of clinicians, neuroscientists, neuropathologists, and neuroimaging specialists to evaluate the current state of biomarker development for chronic traumatic encephalopathy (CTE) and to outline priorities for advancing translational research for this important area.
Charles Bernick, Brooke Conway Kleven, Michael L. Alosco, Hector Arciniega, Nicholas Ashton, Andrew Bender, Kevin F. Bieniek, Dietmar Cordes, Laura Cordes, Douglas I. Katz, Dirk Keene, Jefferson Kinney, LeeAnn Mandarino, Dawn Matthews, Anne McKee, Jesse Mez, Edwin C. Oh, Elaine Peskind, Gil D. Rabinovici, Eric M. Reiman, Robert A. Stern, Neil Vasdev, Henrik Zetterberg, Xiaowei Zhuang, Jeffrey L. Cummings   +24 more
wiley   +1 more source

Entorhinal grid-like codes for visual space during memory formation

Nature Communications
Eye movements, such as saccades, allow us to gather information about the environment and, in this way, can shape memory. In non-human primates, saccades are associated with the activity of grid cells in the entorhinal cortex.
Luise P. Graichen, Magdalena S. Linder, Lars Keuter, Ole Jensen, Christian F. Doeller, Claus Lamm, Tobias Staudigl, Isabella C. Wagner   +7 more
doaj   +1 more source

Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Functional decline in activities of daily living (ADL)—advanced (AADL), instrumental (IADL), and basic (BADL)—is a hallmark of Alzheimer's disease (AD). However, integrated clinical–neuroanatomical evidence on progression across the AD continuum remains limited, particularly in Latin American populations.
Fernando Henríquez, Patricio Riquelme, Gonzalo Forno, Joaquín Migeot, Rodrigo Henríquez, Patricia Lillo, Daniela Thumala‐Dockendorff, Cecilia Okuma, Cecilia González Campo, Michael Hornberger, Francisco Aboitiz, Andrea Slachevsky   +11 more
wiley   +1 more source

Abnormal amyloid PET usually represents intermediate/high Alzheimer's disease neuropathologic change

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease neuropathologic change (ADNC) classification identifies not/low and intermediate/high levels of neuropathology. Our goal was to assess how frequently a positive amyloid positron emission tomography (PET) scan indicates not/low ADNC and whether this autopsy finding can occur >10 years after a positive amyloid ...
Brian J. Burkett, Heather J. Wiste, Derek R. Johnson, Bradley F. Boeve, Kejal Kantarci, Ronald C. Petersen, David S. Knopman, Prashanthi Vemuri, Jonathan Graff‐Radford, Val Lowe, Petrice M. Cogswell, Jay Pillai, Christopher G. Schwarz, Aivi T. Nguyen, Melissa E. Murray, Dennis W. Dickson, Clifford R. Jack Jr   +16 more
wiley   +1 more source

Correlation between in vivo 18F‐flortaucipir PET and whole‐brain postmortem histological tau signals in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Clinicopathological studies offer crucial interpretations of 18F‐flortaucipir (FTP) tau positron emission tomography (PET) signal but are limited by methods. We leveraged whole‐brain, quantitative immunohistochemical (IHC) Alzheimer's Disease (AD) tau density maps to comprehensively evaluate the FTP tracer.
Yishu Chao, Yuheng Chen, Trevor A. Chadwick, Theresa M. Harrison, Leonardo Iaccarino, Helmut Heinsen, Daniela Ushizima, Duygu Tosun, William J. Jagust, Lea T. Grinberg   +9 more
wiley   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, Volume 99, Issue 5, Page 1343-1353, May 2026.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source