Results 21 to 30 of about 40,448 (203)

Entorhinal cortex dysfunction in Alzheimer's disease

Trends in Neurosciences, 2023
The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and cell death. Recently, brain imaging studies from preclinical AD patients and electrophysiological recordings from AD animal models have shown that impaired neuronal ...
openaire   +4 more sources

Effects of entorhinal cortex lesions on memory in different tasks

Brazilian Journal of Medical and Biological Research, 1997
Lesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different
G.P. Gutierrez-Figueroa, C. Dalmaz, I. Izquierdo   +2 more
doaj   +1 more source

Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex

Communications Biology, 2023
The hippocampus and entorhinal cortex are deeply involved in learning and memory. However, little is known how ongoing events are processed in the hippocampal-entorhinal circuit.
Shogo Soma, Shinya Ohara, Satoshi Nonomura, Naofumi Suematsu, Junichi Yoshida, Eva Pastalkova, Yutaka Sakai, Ken-Ichiro Tsutsui, Yoshikazu Isomura   +8 more
doaj   +1 more source

A sense of direction in human entorhinal cortex [PDF]

Proceedings of the National Academy of Sciences, 2010
Finding our way in spatial environments is an essential part of daily life. How do we come to possess this sense of direction? Extensive research points to the hippocampus and entorhinal cortex (EC) as key neural structures underlying spatial navigation.
Joshua, Jacobs, Michael J, Kahana, Arne D, Ekstrom, Matthew V, Mollison, Itzhak, Fried   +4 more
openaire   +2 more sources

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Heterosynaptic plasticity of the visuo-auditory projection requires cholecystokinin released from entorhinal cortex afferents

eLife
The entorhinal cortex is involved in establishing enduring visuo-auditory associative memory in the neocortex. Here we explored the mechanisms underlying this synaptic plasticity related to projections from the visual and entorhinal cortices to the ...
Wenjian Sun, Haohao Wu, Yujie Peng, Xuejiao Zheng, Jing Li, Dingxuan Zeng, Peng Tang, Ming Zhao, Hemin Feng, Hao Li, Ye Liang, Junfeng Su, Xi Chen, Tomas Hökfelt, Jufang He   +14 more
doaj   +1 more source

Medial temporal pathways for contextual learning: Network c- mapping in rats with or without perirhinal cortex lesions

Brain and Neuroscience Advances, 2017
Background: In the rat brain, context information is thought to engage network interactions between the postrhinal cortex, medial entorhinal cortex, and the hippocampus.
Lisa Kinnavane, Eman Amin, Cristian M. Olarte-Sánchez, John P. Aggleton   +3 more
doaj   +1 more source

Structural Analysis of Brain Hub Region Volume and Cortical Thickness in Patients with Mild Cognitive Impairment and Dementia

Medicina, 2020
Background and Objectives: A complex network of axonal pathways interlinks the human brain cortex. Brain networks are not distributed evenly, and brain regions making more connections with other parts are defined as brain hubs.
Nauris Zdanovskis, Ardis Platkājis, Andrejs Kostiks, Guntis Karelis   +3 more
doaj   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Distribution of calcium-binding proteins immunoreactivity in the bottlenose dolphin entorhinal cortex

Frontiers in Neuroanatomy
IntroductionThe entorhinal cortex has been shown to be involved in high-level cognitive functions in terrestrial mammals. It can be divided into two main areas: the lateral entorhinal area (LEA) and the medial entorhinal area (MEA).
Jean-Marie Graïc, Annamaria Grandis, Simona Sacchini, Claudio Tagliavia, Giulia Salamanca, Bruno Cozzi, Cristiano Bombardi   +6 more
doaj   +1 more source