Results 41 to 50 of about 41,716 (223)

Trajectory Encoding in the Hippocampus and Entorhinal Cortex [PDF]

Neuron, 2000
We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same position depending on where the ...
Frank, Loren M, Brown, Emery N, Wilson, Matthew   +2 more
openaire   +2 more sources

Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex.

PLoS ONE, 2022
Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex.
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapman   +5 more
doaj   +1 more source

Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory

Neural Plasticity, 2008
The entorhinal cortex plays an important role in spatial memory and episodic memory functions. These functions may result from cellular mechanisms for integration of the afferent input to entorhinal cortex.
Michael E. Hasselmo, Mark P. Brandon
doaj   +1 more source

Depressive Symptom Dimensions and Their Association with Hippocampal and Entorhinal Cortex Volumes in Community Dwelling Older Adults

Frontiers in Aging Neuroscience, 2018
Objective: Research has shown that depression is a risk factor for Alzheimer’s disease (AD) and subsequent cognitive decline. This is compounded by evidence showing an association between depression and reduced hippocampal volumes; a primary structure ...
Deirdre M. O’Shea, Deirdre M. O’Shea, Deirdre M. O’Shea, Vonetta M. Dotson, Vonetta M. Dotson, Vonetta M. Dotson, Adam J. Woods, Adam J. Woods, Adam J. Woods, Eric C. Porges, Eric C. Porges, Eric C. Porges, John B. Williamson, John B. Williamson, John B. Williamson, Andrew O’Shea, Andrew O’Shea, Ronald Cohen, Ronald Cohen, Ronald Cohen   +19 more
doaj   +1 more source

A sense of direction in human entorhinal cortex [PDF]

Proceedings of the National Academy of Sciences, 2010
Finding our way in spatial environments is an essential part of daily life. How do we come to possess this sense of direction? Extensive research points to the hippocampus and entorhinal cortex (EC) as key neural structures underlying spatial navigation.
Joshua, Jacobs, Michael J, Kahana, Arne D, Ekstrom, Matthew V, Mollison, Itzhak, Fried   +4 more
openaire   +2 more sources

Network Neurodegeneration in Alzheimer’s Disease via MRI based Shape Diffeomorphometry and High Field Atlasing

Frontiers in Bioengineering and Biotechnology, 2015
This paper examines MRI analysis of neurodegeneration in Alzheimer’s Disease (AD) in a network of structures within the medial temporal lobe using diffeomorphometry methods coupled with high-field atlasing in which the entorhinal cortex is partitioned ...
Michael I Miller, Michael I Miller, Michael I Miller, J Tilak eRatnanather, J Tilak eRatnanather, J Tilak eRatnanather, Daniel J. Tward, Daniel J. Tward, Daniel J. Tward, Timothy eBrown, David S Lee, David S Lee, Michael eKetcha, Michael eKetcha, Kanami eMori, Mei-Chang eWang, Susumu eMori, Marilyn S Albert, Laurent eYounes, Laurent eYounes, Laurent eYounes   +20 more
doaj   +1 more source

Functional topography of the human entorhinal cortex [PDF]

eLife, 2015
Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-based analyses to identify corresponding subregions in ...
Tobias Navarro Schröder, Koen V Haak, Nestor I Zaragoza Jimenez, Christian F Beckmann, Christian F Doeller   +4 more
openaire   +5 more sources

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source

Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum

Nature Communications, 2019
In rodents, cells in the medial entorhinal cortex and subiculum are known to encode the allocentric direction to nearby walls and boundaries. Here, using fMRI the authors show that this is also true in humans, with allocentric boundary direction being ...
J. P. Shine, J. P. Valdés-Herrera, C. Tempelmann, T. Wolbers   +3 more
doaj   +1 more source

Anatomy and Function of the Primate Entorhinal Cortex

Annual Review of Vision Science, 2020
The entorhinal cortex (EC) is a critical element of the hippocampal formation located within the medial temporal lobe (MTL) in primates. The EC has historically received attention for being the primary mediator of cortical information going into and coming from the hippocampus proper.
Garcia, Aaron D, Buffalo, Elizabeth A
openaire   +2 more sources