Results 41 to 50 of about 40,545 (235)

Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory

Neural Plasticity, 2008
The entorhinal cortex plays an important role in spatial memory and episodic memory functions. These functions may result from cellular mechanisms for integration of the afferent input to entorhinal cortex.
Michael E. Hasselmo, Mark P. Brandon
doaj   +1 more source

Presurgical magnetoencephalography‐derived network control metrics distinguish successful hippocampal resection vs sparing in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Surgical decision‐making in temporal lobe epilepsy (TLE) faces a critical challenge in determining whether the hippocampus can be safely spared during anterior temporal resection, particularly when surgery involves the language‐dominant hemisphere.
Guhan Seshadri NP, Himanshu Kumar, Neha Sara John, Andreas V. Alexopoulos, Richard C. Burgess, Hiroatsu Murakami, Balu Krishnan   +6 more
wiley   +1 more source

Depressive Symptom Dimensions and Their Association with Hippocampal and Entorhinal Cortex Volumes in Community Dwelling Older Adults

Frontiers in Aging Neuroscience, 2018
Objective: Research has shown that depression is a risk factor for Alzheimer’s disease (AD) and subsequent cognitive decline. This is compounded by evidence showing an association between depression and reduced hippocampal volumes; a primary structure ...
Deirdre M. O’Shea, Deirdre M. O’Shea, Deirdre M. O’Shea, Vonetta M. Dotson, Vonetta M. Dotson, Vonetta M. Dotson, Adam J. Woods, Adam J. Woods, Adam J. Woods, Eric C. Porges, Eric C. Porges, Eric C. Porges, John B. Williamson, John B. Williamson, John B. Williamson, Andrew O’Shea, Andrew O’Shea, Ronald Cohen, Ronald Cohen, Ronald Cohen   +19 more
doaj   +1 more source

Ultrafast oscillations in the human brain and their functional significance

Epilepsia, EarlyView.
Abstract Objective The upper frequency limit of human brain activity remains unknown. Using ultrahigh sampling rate (≥20 kHz) intracranial microelectroencephalography, this study aimed to systematically explore and quantitatively characterize brain field oscillations beyond the established high‐frequency oscillation range (>2 kHz), and to determine ...
Milan Brázdil, Vojtěch Trávníček, Jonathan Curot, Martin Pail, Monika Służewska‐Niedźwiedź, Robert Roman, Filip Plešinger, Emmanuel Barbeau, Michal Kucewicz, Petr Klimeš, Jan Cimbálník, Pavel Jurák, William C. Stacey, Gregory A. Worrell   +13 more
wiley   +1 more source

Network Neurodegeneration in Alzheimer’s Disease via MRI based Shape Diffeomorphometry and High Field Atlasing

Frontiers in Bioengineering and Biotechnology, 2015
This paper examines MRI analysis of neurodegeneration in Alzheimer’s Disease (AD) in a network of structures within the medial temporal lobe using diffeomorphometry methods coupled with high-field atlasing in which the entorhinal cortex is partitioned ...
Michael I Miller, Michael I Miller, Michael I Miller, J Tilak eRatnanather, J Tilak eRatnanather, J Tilak eRatnanather, Daniel J. Tward, Daniel J. Tward, Daniel J. Tward, Timothy eBrown, David S Lee, David S Lee, Michael eKetcha, Michael eKetcha, Kanami eMori, Mei-Chang eWang, Susumu eMori, Marilyn S Albert, Laurent eYounes, Laurent eYounes, Laurent eYounes   +20 more
doaj   +1 more source

Paroxysmal slow waves mark ictal networks

Epilepsia, EarlyView.
Abstract Objective Epilepsy diagnosis and treatment monitoring are hindered by the episodic, heterogeneous expression of seizures and by normal‐appearing scalp electroencephalography (EEG) in many patients. We previously described paroxysmal slow‐wave events (PSWEs), brief epochs of broadband slowing detectable on EEG in people with epilepsy.
Florent J. M. Boyer‐Aymé, Hamza Imtiaz, Ofer Prager, Evyatar Swissa, Alaa Abu Ahmad, Yonatan Serlin, Refat Aboghazleh, Ilan Goldberg, Maayan Ben nun Caller, Idit Tamir, Oded Shor, Ben Whatley, Felix Benninger, Alon Friedman   +13 more
wiley   +1 more source

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

Cross‐material memory prediction: Influence of preoperative visual memory on postoperative verbal memory change after left anterior temporal lobe resection in people with epilepsy

Epilepsia, EarlyView.
Abstract Objective Left anterior temporal lobe resection (TLR) in people with epilepsy is associated with a high risk of postoperative verbal memory decline. Whereas substantial evidence supports the role of preoperative verbal memory in predicting postoperative verbal memory change, the potential contribution of preoperative visual memory has been ...
Lea Marie Reisch, Anne Hagemann, Johanna Lena Hopf, Florian J. Muecke, Friedrich G. Woermann, Christian G. Bien, Philip Grewe   +6 more
wiley   +1 more source

Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum

Nature Communications, 2019
In rodents, cells in the medial entorhinal cortex and subiculum are known to encode the allocentric direction to nearby walls and boundaries. Here, using fMRI the authors show that this is also true in humans, with allocentric boundary direction being ...
J. P. Shine, J. P. Valdés-Herrera, C. Tempelmann, T. Wolbers   +3 more
doaj   +1 more source

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source