Results 61 to 70 of about 40,448 (203)

Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats

Neurobiology of Disease, 2008
We investigated the potential of 4-AP (50–100 μM) to induce seizure-like events (SLEs) in combined entorhinal cortex–hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus.
Robert K. Zahn, Else A. Tolner, Christian Derst, Clemens Gruber, Rüdiger W. Veh, Uwe Heinemann   +5 more
doaj   +1 more source

Effect of reward on electrophysiological signatures of grid cell population activity in human spatial navigation

Scientific Reports, 2021
The regular equilateral triangular periodic firing pattern of grid cells in the entorhinal cortex is considered a regular metric for the spatial world, and the grid-like representation correlates with hexadirectional modulation of theta (4–8 Hz) power in
Wenjing Wang, Wenxu Wang
doaj   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Functional subregions of the human entorhinal cortex

eLife, 2015
The entorhinal cortex (EC) is the primary site of interactions between the neocortex and hippocampus. Studies in rodents and nonhuman primates suggest that EC can be divided into subregions that connect differentially with perirhinal cortex (PRC) vs parahippocampal cortex (PHC) and with hippocampal subfields along the proximo-distal axis. Here, we used
Anne Maass, David Berron, Laura A Libby, Charan Ranganath, Emrah Düzel   +4 more
openaire   +6 more sources

A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus.

PLoS ONE
Alzheimer's disease varies by sex but is broadly characterized by widespread neurodegeneration and the accumulation of insoluble amyloid plaques and neurofibrillary tangles.
Alyssa M Ash, Sue Rim Baek, Peyton Holder, Sara Singh, Nicholas P Vyleta, Matthew Willman, Kevin R Nash, Jason S Snyder   +7 more
doaj   +1 more source

Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

eLife, 2018
Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the
Tim James Viney, Minas Salib, Abhilasha Joshi, Gunes Unal, Naomi Berry, Peter Somogyi   +5 more
doaj   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Convergent Projections from Perirhinal and Postrhinal Cortices Suggest a Multisensory Nature of Lateral, but Not Medial, Entorhinal Cortex

Cell Reports, 2019
Summary: The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different “where” and “what” pathways enter MTL as parallel parahippocampal cortex (PHC)-medial entorhinal cortex (MEC ...
Thanh P. Doan, Maria J. Lagartos-Donate, Eirik S. Nilssen, Shinya Ohara, Menno P. Witter   +4 more
doaj   +1 more source