Results 71 to 80 of about 73,004 (270)
Mnemonic discrimination relates to perforant path integrity: An ultra-high resolution diffusion tensor imaging study. [PDF]
, 2016 Pattern separation describes the orthogonalization of similar inputs into unique, non-overlapping representations. This computational process is thought to serve memory by reducing interference and to be mediated by the dentate gyrus of the hippocampus ...
Bennett, Ilana J, Stark, Craig EL
core +2 more sources
Anatomy and Function of the Primate Entorhinal Cortex
Annual Review of Vision Science, 2020 The entorhinal cortex (EC) is a critical element of the hippocampal formation located within the medial temporal lobe (MTL) in primates. The EC has historically received attention for being the primary mediator of cortical information going into and coming from the hippocampus proper.
Garcia, Aaron D, Buffalo, Elizabeth A
openaire +2 more sources
Epilepsia, EarlyView.Abstract Objective The thalamus is a key hub in seizure propagation, and its nuclei are emerging targets for neuromodulation. However, the contributions of individual nuclei to epileptic networks remain unclear, particularly in children, who are less studied than adults.
Xiyu Feng +11 more
wiley +1 more source
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology
Nature Communications, 2016 Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical ...
Taylor W. Schmitz +2 more
doaj +1 more source
Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults
Frontiers in Human Neuroscience, 2014 Alzheimer’s disease (AD) risk genes alter brain structure and function decades before disease onset. Apolipoprotein E (APOE) is the strongest known genetic risk factor for Alzheimer’s disease, and a related gene, apolipoprotein J (APOJ), also affects ...
Amanda Marie Dibattista +4 more
doaj +1 more source
Space, Time and Learning in the Hippocampus: How Fine Spatial and Temporal Scales Are Expanded into Population Codes for Behavioral Control [PDF]
, 2006 The hippocampus participates in multiple functions, including spatial navigation, adaptive timing, and declarative (notably, episodic) memory. How does it carry out these particular functions?
Gorchetchnikov, Anatoli +1 more
core +1 more source
Speed cells in the medial entorhinal cortex
Nature, 2015 Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous ...
Emilio Kropff +3 more
openaire +3 more sources
Trajectory Encoding in the Hippocampus and Entorhinal Cortex [PDF]
Neuron, 2000 We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same position depending on where the ...
Frank, Loren M +2 more
openaire +2 more sources
Epilepsia, EarlyView.Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras +6 more
wiley +1 more source
Neurobiology of Disease, 2008 We investigated the potential of 4-AP (50–100 μM) to induce seizure-like events (SLEs) in combined entorhinal cortex–hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus.
Robert K. Zahn +5 more
doaj +1 more source