Results 91 to 100 of about 40,448 (203)

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]‐SMBT‐1 Positron‐Emission Tomography

Glia, Volume 74, Issue 8, August 2026.
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Lewis S. Crawford, James W. M. Kang, OIivia I. Davanzo, Hyunsol Lim, Sabrina Salberg, Marissa Srgo, Crystal Li, Gaelle M. Emvalomenos, Bianca Jupp, Matthew Long, Wayne Noonan, Mohammad B. Haskali, Richelle Mychasiuk, Kevin A. Keay, Luke A. Henderson   +14 more
wiley   +1 more source

Dissecting the Strain and Sex Specific Connectome Signatures of Unanesthetized C57BL/6J and DBA/2J Mice Using Magnetic Resonance Imaging

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
C57BL/6J and DBA/2J mice were used to investigate strain and sex‐specific features of the brain connectome in awake animals using magnetic resonance imaging (MRI). By combining resting‐state and diffusion MRI, we found significant differences in the motor, sensory, limbic, and salience networks between C57BL/6J and DBA/2J mice.
Tanzil M. Arefin, Hayreddin Said Ünsal, Thomas Neuberger, Nanyin Zhang, Helen M. Kamens   +4 more
wiley   +1 more source

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Positron emission tomography (PET) is a valuable tool for assessing tau pathology in Alzheimer's disease (AD), but it is not widely accessible. Clarifying the relationship between fluid tau species and tau PET in AD may allow for the identification of fluid biomarkers that could serve as more accessible surrogates for tau PET ...
Julie Lee, Emily Olafson, Balazs Toth, Ellen Casavant, Stephen Schauer, Tobias Bittner, Matthew R. Meyer, Philip B. Verghese, Venky Venkatesh, Tim West, Joel B. Braunstein, Anne Biever, Emilia Calderon, Melanie Mandl, Anna Bayfield, Casper C. Hoogenraad, Edmond Teng, Cecilia Monteiro, Veronica G. Anania, Sandra M. Sanabria Bohórquez, Felix L. Yeh   +20 more
wiley   +1 more source

Sleep fragmentation correlates with amyloid beta deposition at brain autopsy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Poor sleep is a symptom and candidate risk factor for Alzheimer's disease (AD). We investigated whether objective and subjective longitudinal sleep measures correlated with AD pathology at brain autopsy. METHODS Rush Memory and Aging Project (MAP) participants (n = 798; Meanage at baseline = 81.72) underwent annual evaluation with
Mark A. Rudolf, Yee To Ng, Andrew P. Lieberman   +2 more
wiley   +1 more source

Boundary Vector Cells Encode a Future‐Biased Spectrum of Positions in the Rat

Hippocampus, Volume 36, Issue 4, July 2026.
ABSTRACT Spatial tuning is a hallmark property of neural firing in the hippocampal formation. Yet, that tuning is often less well correlated with the instantaneous current position of an animal than it is with an integrated version of the past or future state of the animal.
Ehren Lee Newman, Inna Mashanova‐Galikova, Zoran Tiganj, Colin Lever   +3 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, Volume 36, Issue 4, July 2026.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp   +2 more
wiley   +1 more source

Status epilepticus and thinning of the entorhinal cortex

Epilepsy & Behavior
Status epilepticus (SE) carries risks of morbidity and mortality. Experimental studies have implicated the entorhinal cortex in prolonged seizures; however, studies in large human cohorts are limited. We hypothesised that individuals with temporal lobe epilepsy (TLE) and a history of SE would have more severe entorhinal atrophy compared to others with ...
Jonathan Horsley, Yujiang Wang, Callum Simpson, Vytene Janiukstyte, Karoline Leiberg, Bethany Little, Jane de Tisi, John Duncan, Peter N. Taylor   +8 more
openaire   +4 more sources

Mental navigation in the primate entorhinal cortex

Nature
AbstractA cognitive map is a suitably structured representation that enables novel computations using previous experience; for example, planning a new route in a familiar space1. Work in mammals has found direct evidence for such representations in the presence of exogenous sensory inputs in both spatial2,3 and non-spatial domains4–10. Here we tested a
Sujaya Neupane, Ila Fiete, Mehrdad Jazayeri   +2 more
openaire   +2 more sources