Results 91 to 100 of about 41,716 (223)

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Adolescent Ethanol Exposure Disrupts the Mature Phenotype of Surviving Neuroprogenitors in Female Mice

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Rodent models of human adolescent binge drinking persistently reduce adult neurogenesis and induce innate immune signaling cascades, suggesting long‐lasting dysfunction in the hippocampal neurogenic niche. Nevertheless, many neuroprogenitors survive, and the impact of adolescent ethanol on the mature phenotype of these surviving neurons is ...
Kaitlyn Campbell, Madison McDowell, Eymani Alston, Hunter Kelley, Michael Kasten, Paul B. Manis, Fulton Crews, Victoria Macht   +7 more
wiley   +1 more source

Mental Scene and Memory Construction and the Hippocampus

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT A neurocomputational theory of scene and memory construction during memory recall, prospective thinking, and autobiographical memory is described. The theory describes the nature of the representation of scenes using spatial view cells in a continuous attractor network in the medial parahippocampal cortex, and how the location in the scene ...
Edmund T. Rolls
wiley   +1 more source

Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A High‐Resolution Whole‐Brain fMRI Investigation

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Mnemonic discrimination—the ability to distinguish between existing memories and similar new inputs—supports accurate memory in the face of interference (e.g., in a card game, recognizing that the card you are currently seeing, the King of Hearts, is distinct from the King of Diamonds you encountered earlier in the same hand).
Min Sung Seo, Rebecca L. Wagner, Jordan D. Chamberlain, Kelsey L. Canada, Nancy A. Dennis   +4 more
wiley   +1 more source

Status epilepticus and thinning of the entorhinal cortex

Epilepsy & Behavior
Status epilepticus (SE) carries risks of morbidity and mortality. Experimental studies have implicated the entorhinal cortex in prolonged seizures; however, studies in large human cohorts are limited. We hypothesised that individuals with temporal lobe epilepsy (TLE) and a history of SE would have more severe entorhinal atrophy compared to others with ...
Jonathan Horsley, Yujiang Wang, Callum Simpson, Vytene Janiukstyte, Karoline Leiberg, Bethany Little, Jane de Tisi, John Duncan, Peter N. Taylor   +8 more
openaire   +4 more sources

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2002-2016, October 2026.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Early neurofibrillary tau degeneration in the entorhinal cortex (EC) is a hallmark of Alzheimer's disease (AD) and aging. We propose a biomechanical cascade hypothesis, suggesting proximity to the tentorial incisura (TI) may render the EC susceptible to chronic mechanical stress, potentially contributing to tau pathology.
Luyue Zhang, Ana M. Franceschi, John F. Crary, Frank A. Provenzano, for the Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Our prior work demonstrated systemic P301L‐tau injections in mice with mature amyloid resulted in several‐fold enhancement of tauopathy compared to non‐transgenic (NTg) littermates. METHODS APP+PS1 mice were injected intravenously with AAV.CAP‐B10 expressing P301L tau (A/P+P301L).
Dylan J. Finneran, Taylor Desjarlais, Brianna M. Jackman, David Morgan, Marcia N. Gordon   +4 more
wiley   +1 more source