Results 111 to 120 of about 41,716 (223)
Most Early‐Born Subplate Neurons Persist as Layer 6b Neurons in the Adult Mouse Neocortex
Comprehensive EdU birthdating and 3D volumetric analyses revealed that most early‐born subplate neurons (SpNs) persist into adulthood as layer 6b (L6b) neurons in the mouse neocortex. Green circles indicate SpNs/L6b neurons, and magenta labeling indicates EdU‐labeled early‐born neurons.
Yusuke Sugita +3 more
wiley +1 more source
The entorhinal cortex and hippocampus are interconnected brain regions required for episodic learning and memory. For this functional encoding, correct assembly of specific synaptic connections across this circuit is critical during development. To guide
Jordan D. Donohue +8 more
doaj +1 more source
Whole‐brain input–output mapping reveals that DMDLepRb and DMHLepRb neurons share a highly conserved global connectivity architecture yet exhibit local connection biases: DMDLepRb neurons preferentially integrate arousal and defensive signals, whereas DMHLepRb neurons favor viscerosensory and metabolic inputs, uncovering a principle of conserved global
Yaxin Hao +8 more
wiley +1 more source
Ictal Epileptogenic Network Differences in Posterior Cingulate Epilepsy Subtypes Based on SEEG
Visual recall function was more severely impaired in patients with RSC epilepsy than in those with PCC epilepsy. During the propagation phase, ipsilateral mesial temporal structures exhibited a predominant “driver” role, whereas lateral temporal cortices functioned as “receivers.” RSC epilepsy also demonstrated stronger propagation strength toward ...
Zhaofen Yan +10 more
wiley +1 more source
In patients with post‐COVID‐19 condition, a significant shift in gut microbiota composition can be observed, marked by a decrease in butyrate‐producing taxa. Relevant taxa correlate with clinical symptoms, structural and functional brain changes, which suggests potential therapeutic targets and highlight the need for further investigation in their ...
Sophie Wetz +8 more
wiley +1 more source
Greater growth of white matter signal aberration (WMSA) volume, the most common age‐related finding on brain MRI, is connected to increased cortical thinning, more so in men than women. In men only, the cortical regions experiencing increased thinning due to WMSA growth displayed a concomitant cortical area expansion.
Asta K. Håberg +2 more
wiley +1 more source
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang +5 more
wiley +1 more source
Through a single metabolic intervention, Sleeve Gastrectomy improves metabolic health and attenuates Alzheimer's pathology in 3xTg‐AD mice across dietary contexts. It reduces cortical amyloid and neuroinflammation via region‐specific brain insulin–autophagy signaling and rescues memory under Western‐diet stress, independent of caloric intake.
Reji Babygirija +13 more
wiley +1 more source

