Results 111 to 120 of about 40,545 (235)
Exploring longitudinal relationships among Alzheimer's disease biomarkers
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION While most studies of Alzheimer's disease (AD) examine cross‐sectional relationships among biomarkers, longitudinal relationships are also highly relevant. METHODS This study in the Alzheimer's Disease Neuroimaging Initiative cohort (n = 373) used non‐parametric Spearman correlations to explore the relationships of baseline values
Benjamin Saef +25 more
wiley +1 more source
Sex specificity of resistance to caTAUstrophe
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION As amyloid beta (Aβ) accumulates, tau pathology spreads beyond medial temporal lobe (MTL) into neocortical (NEO) regions, though some older adults resist this progression, or what we call here “caTAUstrophe.” Given previous evidence of higher tau levels in women, we tested how tau resistance presented in men and women separately ...
Maria Carrigan +21 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Alzheimer's disease neuropathologic change (ADNC) and limbic‐predominant age‐related transactive response DNA‐binding protein 43 kDa (TDP‐43) encephalopathy neuropathologic change (LATENC) are common in older adults, yet differences in brain morphometry patterns when one or both pathologies are present remain unclear.
Khalid Saifullah +7 more
wiley +1 more source
Hormone replacement therapy and its association with LATE‐NC in older adults
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA‐binding protein 43 (TDP‐43) encephalopathy neuropathological change (LATE‐NC) is a cause of dementia resembling Alzheimer's disease (AD). The 90+ Study found women using hormone replacement therapy (HRT) two to three decades before death had lower odds of LATE‐NC.
Yohana M. Kim +6 more
wiley +1 more source
Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage‐informed framework in which rapid eye movement (REM) sleep‐related respiratory events amplify vascular ...
Destiny E. Berisha +2 more
wiley +1 more source
Arachnoid granulation morphologies and β‐amyloid and tau pathology in older adults
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Arachnoid granulations (AG) prominently enlarge with age, yet limited studies evaluate AG in neurodegeneration. Here, we investigate the associations of AG morphologies with Alzheimer's disease (AD). METHODS Macroscopic AG properties were evaluated along dorsal post mortem brain specimens (n = 882).
Rashi I. Mehta +7 more
wiley +1 more source
Vulnerability of locus coeruleus connections to aging and Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION The locus coeruleus (LC) is important in coordinating communication between brain regions through its widespread connections. However, the organization of its connections, and its changes with aging and Alzheimer's disease (AD), remains unclear.
Blanca Zufiria‐Gerbolés +9 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Subjective cognitive concerns frequently diverge from objective cognitive performance in cognitively unimpaired (CU) older adults, yet the neurobiological basis of this mismatch remains unclear. METHODS In 648 participants from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE), we defined four
Lu Wan +20 more
wiley +1 more source