Results 101 to 110 of about 40,545 (235)

Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dementia clinical risk scores (CRSs) provide accessible tools for identifying individuals at risk for Alzheimer's disease (AD) and related dementias, yet their performance across diverse populations and relationships to AD endophenotypes remains unclear.
Meri Okorie, Xiaqing Jiang, Kristine Yaffe, Jennifer S. Yokoyama, Shea J. Andrews, for the Health and Aging Brain Study–Health Disparities   +5 more
wiley   +1 more source

Lower cardiac output is a risk factor for faster cerebral atrophy over a 11‐year follow‐up period in APOE‐ε4 carriers

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Subclinical lower cardiac output (volume of blood pumped per minute) cross‐sectionally relates to smaller cerebral gray matter volumes in older adults. This study relates cardiac output to longitudinal gray matter volumes among middle‐aged and older adults over an 11‐year period.
Elizabeth E. Moore, Panpan Zhang, Omair A. Khan, Dandan Liu, Deepak K. Gupta, Kimberly R. Pechman, Katherine A. Gifford, Bennett A. Landman, Timothy J. Hohman, Angela L. Jefferson   +9 more
wiley   +1 more source

Mental navigation in the primate entorhinal cortex

Nature
AbstractA cognitive map is a suitably structured representation that enables novel computations using previous experience; for example, planning a new route in a familiar space1. Work in mammals has found direct evidence for such representations in the presence of exogenous sensory inputs in both spatial2,3 and non-spatial domains4–10. Here we tested a
Sujaya Neupane, Ila Fiete, Mehrdad Jazayeri   +2 more
openaire   +2 more sources

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source

BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION We examined whether locus coeruleus (LC) contrast, an indirect proxy for neuronal density and structural health, was related to delayed episodic memory in healthy older adults (OAs) and those with mild cognitive impairment (MCI) and its association with encoding‐related brain activity, controlling for emotional salience.
Lucia Penalba‐Sánchez, Yeo‐Jin Yi, Elif Kurt, Grazia Daniela Femminella, Clare Loane, Millie Duckett, Alina Zhunussova, Nikolaus Weiskopf, Martina F Callaghan, Ray Dolan, Robert J Howard, Emrah Düzel, Dorothea Hämmerer   +12 more
wiley   +1 more source

Increased levels of GFAP and purinergic P2X7 receptor in Alzheimer’s disease brain are associated with Aβ, tau pathologies and synaptic loss

Alzheimer’s Research & Therapy
Astrogliosis plays an important role in Alzheimer’s disease(AD). We characterized glial fibrillary acidic protein(GFAP) and purinergic P2X7 receptor(P2X7R) alterations in AD and their associations with amyloid-β levels, tau pathology and synaptic density.
Cinzia A. Maschio, Oscar Moreno, Junlong Wang, Upasana Maheshwari, Annika Keller, Uwe Konietzko, Daniel Razansky, Agneta Nordberg, Axel Rominger, Christoph Hock, Jordi Llop, Roger M. Nitsch, Ruiqing Ni   +12 more
doaj   +1 more source

miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. METHODS We utilized in silico analyses of published databases, MIR155‐deleted and ‐overexpressing human induced pluripotent stem cell ...
Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich   +10 more
wiley   +1 more source

Correlation of the Changes of Gray Matter Volume with Aβ Deposition and Learning and Memory Abilities in APP/PS1 Mice at Different Periods

康复学报, 2020
Objective:To analyze the correlation in the changes of cerebral gray matter volume and the ability of memory learning, and the deposition of β-amyloid protein (Aβ) in related brain regions of Alzheimer's disease (AD) double-transgenic APP/PS1 model mice,
Yuhao ZHANG, Hao JIN, Xiufeng ZHANG, Shengxiang LIANG, Weilin LIU, Jing TAO, Lidian CHEN   +6 more
doaj  

Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine‐related dysfunction on tau and its impact on cognition

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Animal models demonstrated that pharmacologically‐induced lesioning of the locus coeruleus (LC), the brain's primary source of norepinephrine, triggered astrocyte reactivity, exacerbating Alzheimer's disease (AD) pathology and cognitive deficits.
Prokopis C. Prokopiou, Maxime Van Egroo, Joost M. Riphagen, Marion Baillet, Nicholas J. Ashton, Shorena Janelidze, Reisa A. Sperling, Keith A. Johnson, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Heidi I. L. Jacobs   +11 more
wiley   +1 more source

Entorhinal grid-like codes for visual space during memory formation

Nature Communications
Eye movements, such as saccades, allow us to gather information about the environment and, in this way, can shape memory. In non-human primates, saccades are associated with the activity of grid cells in the entorhinal cortex.
Luise P. Graichen, Magdalena S. Linder, Lars Keuter, Ole Jensen, Christian F. Doeller, Claus Lamm, Tobias Staudigl, Isabella C. Wagner   +7 more
doaj   +1 more source