Results 101 to 110 of about 41,716 (223)

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau‐PET.
Isabella Bizzi, Arthur C. Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Firoza Z. Lussier, Cécile Tissot, Gleb Bezgin, Étienne Aumont, Tevy Chan, Seyyed Ali Hosseini, Delphine Oliva‐Lopez, Marina Pereira Gonçalves, Guilherme Povala, Pamela C. L. Ferreira, Bruna Bellaver, Livia Amaral, Emma Ruppert, Marina Scop Medeiros, Rayan Mroué, Andréia Rocha, Kok Pin Ng, Eduardo R. Zimmer, Joseph Masdeu, Belen Pascual, Val J. Lowe, Hwamee Oh, David N. Soleimani‐Meigooni, Juan Fortea, Zahinoor Ismail, Suzanne Baker, Tharick A Pascoal, Pedro Rosa‐Neto, for the HEAD Study, Cristiano S Aguzzoli, Livia Amaral, Guilherme Bauer‐Negrini, Bruna Bellaver, Ann D Cohen, Alvaro de Oliveira Franco, Douglas T Leffa, Pamela C L Ferreira, Firoza Z Lussier, Marina S Medeiros, Rayan Mroué, Markley S Oliveira, Tharick A Pascoal, Guilherme Povala, Andréia Rocha, Matheus S Rodrigues, Emma Ruppert, Pampa Saha, Juli Singer, Carolina Soares, Dana L Tudorascu, Raphael L Tuma, Suzanne L Baker, Cécile Tissot, Hsin‐Yeh Tsai, Pedro Rosa‐Neto, Tevy Chan, Vladimir Fonov, Yasser Iturria‐Medina, Wan Lu Jia, Jesse Klostranec, Maxime Montembault, Nesrine Rahmouni, Jenna Stevenson, Karine Provost, Paolo Vitali, Selma Avdagic, Emerine Cummings, Brian A Gordon, Danielle Gray, Victoria Tate, Joseph C Masdeu, Belen Pascual, Hwamee Oh, Xiaoyang Hu, Val Lowe, David N Soleimani‐Meigooni, Juan Fortea, Arthur Toga, Tatiana Foroud   +83 more
wiley   +1 more source

Associations between plasma biomarker levels and quantitative postmortem neuropathologic measures in Alzheimer's disease and related dementias

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Validation of Alzheimer's disease blood‐based biomarkers (BBMs) has relied largely on amyloid beta (Aβ) and tau positron emission tomography (PET), with limited quantitative neuropathologic correlation studies. We examined associations between BBMs and quantitative postmortem neuropathology in 124 participants from the ...
Celia R. Bianco, Neus Rabaneda‐Lombarte, Hadia Fatima, Johanna Celedon, Derek H. Oakley, Steven E. Arnold, Pia Kivisäkk, Alberto Serrano‐Pozo   +7 more
wiley   +1 more source

Cell‐based polygenic risk scores predict clinical progression and prioritize network‐based therapeutic targets in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Late‐onset Alzheimer's disease (AD) exhibits substantial biological heterogeneity. We developed a framework linking cell‐type–specific polygenic risk profiles to precision medicine in AD. METHODS Cell‐based polygenic risk scores (cbPRSs) derived from single‐nucleus RNA‐seq co‐expression networks were evaluated in Alzheimer's Disease
Nathan Sahelijo, Priya Rajagopalan, Lu Qian, Rufuto Rahman, Daniel Goldstein, Sophia I. Thomopoulos, David A. Bennett, Lindsay A. Farrer, Thor D. Stein, Li Shen, Heng Huang, Kwangsik Nho, Andrew J. Saykin, Christos Davatzikos, Paul M. Thompson, Julia TCW, Gyungah R. Jun   +16 more
wiley   +1 more source

Increased levels of GFAP and purinergic P2X7 receptor in Alzheimer’s disease brain are associated with Aβ, tau pathologies and synaptic loss

Alzheimer’s Research & Therapy
Astrogliosis plays an important role in Alzheimer’s disease(AD). We characterized glial fibrillary acidic protein(GFAP) and purinergic P2X7 receptor(P2X7R) alterations in AD and their associations with amyloid-β levels, tau pathology and synaptic density.
Cinzia A. Maschio, Oscar Moreno, Junlong Wang, Upasana Maheshwari, Annika Keller, Uwe Konietzko, Daniel Razansky, Agneta Nordberg, Axel Rominger, Christoph Hock, Jordi Llop, Roger M. Nitsch, Ruiqing Ni   +12 more
doaj   +1 more source

Plasma eMTBR‐tau243 as a disease biomarker across Alzheimer's disease clinical phenotypes

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION The concentration of endogenous tau microtubule‐binding region containing residue‐243 in plasma (eMTBR‐tau243) has been proposed to be a sensitive biomarker of tangle pathology in Alzheimer's disease (AD). We assessed eMTBR‐tau243 and phosphorylated tau217 (p‐tau217) with tau and Aβ‐positron emission tomography (PET) across ...
Jennifer L. Whitwell, Jerusha G. Bhaskaran, Ryota Satoh, Jonathan Graff‐Radford, Mary M. Machulda, Val J. Lowe, Michelle M. Mielke, Dennis W. Dickson, Shin‐Cheng Tzeng, John Bui, Philip B. Verghese, Tim West, Venky Venkatesh, Keith A. Josephs   +13 more
wiley   +1 more source

Entorhinal grid-like codes for visual space during memory formation

Nature Communications
Eye movements, such as saccades, allow us to gather information about the environment and, in this way, can shape memory. In non-human primates, saccades are associated with the activity of grid cells in the entorhinal cortex.
Luise P. Graichen, Magdalena S. Linder, Lars Keuter, Ole Jensen, Christian F. Doeller, Claus Lamm, Tobias Staudigl, Isabella C. Wagner   +7 more
doaj   +1 more source

Correlation of the Changes of Gray Matter Volume with Aβ Deposition and Learning and Memory Abilities in APP/PS1 Mice at Different Periods

康复学报, 2020
Objective:To analyze the correlation in the changes of cerebral gray matter volume and the ability of memory learning, and the deposition of β-amyloid protein (Aβ) in related brain regions of Alzheimer's disease (AD) double-transgenic APP/PS1 model mice,
Yuhao ZHANG, Hao JIN, Xiufeng ZHANG, Shengxiang LIANG, Weilin LIU, Jing TAO, Lidian CHEN   +6 more
doaj  

Proteomic dysregulation associated with cerebral amyloid angiopathy

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is characterized by impaired vascular amyloid‐β clearance, distinct from Alzheimer's disease (AD), underscoring the need to clarify its molecular basis for predicting therapy‐related amyloid‐related imaging abnormalities. METHODS We analyzed post‐mortem brain proteomics from Religious Orders Study
Sang‐Won Han, Young Ho Park, Jung‐Min Pyun, Paula J. Bice, David A. Bennett, Shahram Oveisgharan, Andrew J. Saykin, SangYun Kim, Kwangsik Nho   +8 more
wiley   +1 more source

Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Alzheimer's disease (AD) is accompanied by persistent disturbances in brain energy metabolism, and microglial glucose metabolic reprogramming constitutes an important link among pathological protein deposition, neuroinflammation, and impaired clearance.
Yuan Chen, Fuyao Li, Junlei Zhang, Mingqing Wei, Jingnian Ni, Ting Li, Lulu Yao, Jinzhou Tian, Jing Shi   +8 more
wiley   +1 more source

Network‐dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Tau pathology in Alzheimer's disease (AD) propagates along the brain's connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to tau‐harboring epicenters. METHODS One hundred thirty‐one amyloid‐positive individuals underwent dynamic [
Lukas Frontzkowski, Sebastian Roemer‐Cassiano, Johannes Gnörich, Daniel Janowitz, Hannah Eyob, Katharina Probst, Dario Dhoqina, Anna Dewenter, Anna Steward, Zeyu Zhu, Madleen Klonowski, Fabian Hirsch, Davina Biel, Melina Paulus, Jonathan Vöglein, Sonja Schönecker, Boris‐Stephan Rauchmann, Carolin Kurz, Carolin Koriath, Jan Häckert, Sophia Stöcklein, Carla Palleis, Robert Perneczky, Johannes Levin, Katharina Buerger, Rudolf A. Werner, Günter Höglinger, Matthias Brendel, Nicolai Franzmeier   +28 more
wiley   +1 more source