Results 51 to 60 of about 40,545 (235)

Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid

Communications Medicine, 2023
Introduction Non-invasive diffusion-weighted imaging (DWI) to assess brain microstructural changes via cortical mean diffusivity (cMD) has been shown to be cross-sectionally associated with tau in cognitively normal older adults, suggesting that it might
Geoffroy Gagliardi, Elena Rodriguez-Vieitez, Victor Montal, Jorge Sepulcre, Ibai Diez, Cristina Lois, Bernard Hanseeuw, Aaron P. Schultz, Michael J. Properzi, Kathryn V. Papp, Gad A. Marshall, Juan Fortea, Keith A. Johnson, Reisa A. Sperling, Patrizia Vannini   +14 more
doaj   +1 more source

Epileptic arousals: A neglected clinical entity

Epilepsia, EarlyView.
Abstract Objective Epileptic arousals (EAs) are seizures characterized solely by arousal from sleep. EAs are unrecognized in current seizure classifications. Their subtle semiology and inconsistently detectable ictal activity in scalp electroencephalography (EEG) complicate differentiation from physiological arousals (PAs). This study characterizes EAs
Lea Fisel, Nóra Pető, Sotirios Kalousios, Nicolas Zabler, Armin Brandt, Peter C. Reinacher, Dieter Riemann, Mohammad F. Khazali, Andreas Schulze‐Bonhage   +8 more
wiley   +1 more source

Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation

Brazilian Journal of Medical and Biological Research, 1997
A total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were
M.S. Zanatta, J.H. Quillfeldt, E. Schaeffer, P.K. Schmitz, J. Quevedo, J.H. Medina, I. Izquierdo   +6 more
doaj   +1 more source

Trajectory Encoding in the Hippocampus and Entorhinal Cortex [PDF]

Neuron, 2000
We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same position depending on where the ...
Frank, Loren M, Brown, Emery N, Wilson, Matthew   +2 more
openaire   +2 more sources

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Nature Communications, 2016
Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical ...
Taylor W. Schmitz, R. Nathan Spreng, The Alzheimer's Disease Neuroimaging Initiative   +2 more
doaj   +1 more source

Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults

Frontiers in Human Neuroscience, 2014
Alzheimer’s disease (AD) risk genes alter brain structure and function decades before disease onset. Apolipoprotein E (APOE) is the strongest known genetic risk factor for Alzheimer’s disease, and a related gene, apolipoprotein J (APOJ), also affects ...
Amanda Marie Dibattista, Benson W Stevens, Benson W Stevens, G William Rebeck, Adam E. Green   +4 more
doaj   +1 more source

Speed cells in the medial entorhinal cortex

Nature, 2015
Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous ...
Emilio Kropff, James E. Carmichael, May-Britt Moser, Edvard I. Moser   +3 more
openaire   +3 more sources

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Predictive grid cells: Future spatial representations in the hippocampal-entorhinal circuit

Neuroscience Research
Place cells in the hippocampus and grid cells in the entorhinal cortex have long been interpreted as neural representations of an animal’s current location in space. However, an increasing amount of theoretical and experimental evidence suggests that the
Ayako Ouchi
doaj   +1 more source