Results 91 to 100 of about 50,610 (294)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Second Law Analysis of Laminar Flow In A Channel Filled With Saturated Porous Media

Entropy, 2005
The entropy generation rate in a laminar flow through a channel filled with saturated porous media is investigated. The upper surface of the channel is adiabatic and the lower wall is assumed to have a constant heat flux.
E. Osalusi, O. D. Makinde
doaj   +1 more source

Insight into High-quality Aerodynamic Design Spaces through Multi-objective Optimization [PDF]

, 2008
An approach to support the computational aerodynamic design process is presented and demonstrated through the application of a novel multi-objective variant of the Tabu Search optimization algorithm for continuous problems to the aerodynamic design ...
Clarkson, P. J., Dawes, Bill, Jaeggi, Daniel, Kipouros, Timoleon, Parks, Geoff, Savill, Mark A.   +5 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Simulation of Entropy Generation under Stall Conditions in a Centrifugal Fan

Entropy, 2014
Rotating stalls are generally the first instability met in turbomachinery, before surges. This 3D phenomenon is characterized by one or more stalled flow cells which rotate at a fraction of the impeller speed. The goal of the present work is to shed some
Lei Zhang, Jinhua Lang, Kuan Jiang, Songling Wang   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Coalescing neutron stars - a step towards physical models III. Improved numerics and different neutron star masses and spins [PDF]

, 2001
(Abridged) In this paper we present a compilation of results from our most advanced neutron star merger simulations, including a description of the employed numerical procedures and a more complete overview over a large number of computed models.
Akmal, Ayal, Baumgarte, Baumgarte, Baumgarte, Bildsten, Blanchet, Blandford, Bonazzola, Bulik, Centrella, Colella, Cook, Cook, Cook, Cooperstein, Cutler, Davies, Duncan, Eichler, Faber, Faber, Flanagan, Freiburghaus, Fryer, H.-Th. Janka, Haensel, Heiselberg, Hilf, Hulse, Janka, Janka, Kalogera, Kochanek, Lai, Lai, Lai, Lai, Lai, Lattimer, Lattimer, Lattimer, Lattimer, Lee, Li, Lombardi, M. Ruffert, Marronetti, Meyer, Mészáros, Mészáros, Nakamura, New, Oohara, Oohara, Paczynski, Paczynski, Popham, Qian, Rasio, Rasio, Rasio, Rosswog, Rosswog, Ruffert, Ruffert, Ruffert, Ruffert, Ruffert, Ruffert, Sawyer, Shen, Shibata, Shibata, Shibata, Shibata, Sumiyoshi, Swesty, Symbalisty, Taniguchi, Thorne, Thorne, Tscharnuter, van den Horn, Waxman, Waxman, Woosley, Woosley, Zhuge   +88 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A novel method for estimating the entropy generation rate in a human body

Thermal Science, 2007
The main objective of this study is to show a method for calculating entropy generation (Sgen) in a human body under various environmental and physiological conditions. The Sgen in a human body is a measure of activeness of motions, reactions, and irreversibility of processes occurring in a body and is a kind of holistic and thermodynamic index, which ...
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source