Results 131 to 140 of about 4,290,745 (350)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Entropy generation in MHD radiative viscous nanofluid flow over a porous wedge using the bivariate spectral quasi-linearization method

Case Studies in Thermal Engineering, 2018
We study the viscous nanofluid flow over a non-isothermal wedge with thermal radiation. The entropy due to irreversible processes in the system may degrade the performance of the thermodynamic system. Studying entropy generation in the flow over a porous
S.P. Goqo, S.D. Oloniiju, H. Mondal, P. Sibanda, S.S. Motsa   +4 more
doaj   +1 more source

Investigation of forced convection enhancement and entropy generation of nanofluid flow through a corrugated minichannel filled with a porous media

, 2020
Corrugating channel wall is considered to be an efficient procedure for achieving improved heat transfer. Further enhancement can be obtained through the utilization of nanofluids and porous media with high thermal conductivity.
Mirza Gheytaghi, Amir (author), Aminian, Ehsan, Moghadasi, Hesam, Hesam Moghadasi, Moghadasi, Hesam (author), Mirza Gheytaghi, Amir, Amir Mirza Gheitaghy, Ehsan Aminian, Hamid Saffari, Aminian, Ehsan (author), Saffari, Hamid (author), Saffari, Hamid   +11 more
core   +1 more source

Entropy Generation Minimization for Energy-Efficient Desalination [PDF]

, 2018
Desalination systems can be conceptualized as power cycles, in which the useful work output is the work of separation of fresh water from saline water. In this framing, thermodynamic analysis provides powerful tools for raising energy efficiency.
Lienhard, John H, John H. Lienhard
core   +1 more source

Physical generalizations of the Rényi entropy [PDF]

International Journal of Modern Physics D, 2019
We present a new type of generalization of the Rényi entropy that follows naturally from its representation as a thermodynamic quantity. We apply it to the case of [Formula: see text]-dimensional conformal field theories (CFTs) reduced on a region bounded by a sphere. It is known how to compute their Rényi entropy as an integral of the thermal entropy
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Effect of Magnetic Field on Entropy Generation Due to Laminar Forced Convection Past a Horizontal Flat Plate

Entropy, 2004
Magnetic field effect on local entropy generation due to steady two-dimensional laminar forced convection flow past a horizontal plate was numerically investigated.
Moh'd A. Al-Nimr, Renhe A. Damseh, Mohammed Q. Al-Odat   +2 more
doaj   +1 more source

Second law analysis for couple stress fluid flow through a porous medium with constant heat flux [PDF]

, 2017
Journal article published in the Journal of Entropy 2017, 19, 498In the present work, entropy generation in the flow and heat transfer of couple stress fluid through an infinite inclined channel embedded in a saturated porous medium is presented. Due to the
Fakoya, Michael Bamidele, Adesanya, Samuel Olumide   +1 more
core  

Entropy generation: Minimum inside and maximum outside

, 2014
Extremum of the entropy generation is evaluated for both maximum and minimum using a thermodynamic approach which is usually applied in engineering to design energy transduction systems.
Umberto Lucia, LUCIA, UMBERTO
core   +1 more source