Results 121 to 130 of about 4,290,745 (350)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Tracing the classical molecular nature of entropy generation

AIP Advances
The second law of thermodynamics and the concept of positive entropy generation are analyzed following classical statistical mechanics methods. Previously, using the generalized Boltzmann–Gibbs entropy and its associated general entropy conservation ...
Michael H. Peters
doaj   +1 more source

A mathematical model for entropy generation in a Powell-Eyring nanofluid flow in a porous channel

Heliyon, 2019
The continuous generation of entropy leads to exergy destruction which reduces the performance of a physical system. Hence, entropy minimization becomes necessary.
Hammed Abiodun Ogunseye, Precious Sibanda   +1 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Entropy Generation of Desalination Powered by Variable Temperature Waste Heat

, 2015
Powering desalination by waste heat is often proposed to mitigate energy consumption and environmental impact; however, thorough technology comparisons are lacking in the literature.
Hyung Chung, Nayar, Kishor Govind, Karan H. Mistry, Kishor Nayar, John Lienhard, Kishor G. Nayar, Mistry, Karan Hemant, Chung, Hyung Won, David M. Warsinger, David Warsinger, Lienhard, John H, Chung, Hyung, John H. Lienhard V, Warsinger, David Elan Martin, Karan Mistry, Hyung Won Chung   +15 more
core   +1 more source

Does a computer have an arrow of time? [PDF]

, 2007
In [Sch05a], it is argued that Boltzmann's intuition, that the psychological arrow of time is necessarily aligned with the thermodynamic arrow, is correct.
Maroney, Owen, Maroney, OJE, O J E Maroney   +2 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Entropy generation in a micropolar fluid flow through an inclined channel

Alexandria Engineering Journal, 2016
In this paper the entropy generation is studied due to micropolar fluid flow through an inclined channel of parallel plates with constant pressure gradient.
D. Srinivasacharya, K. Hima Bindu
doaj   +1 more source

Entropy Generation Analysis of Wildfire Propagation [PDF]

, 2017
Entropy generation is commonly applied to describe the evolution of irreversible processes, such as heat transfer and turbulence. These are both dominating phenomena in fire propagation.
Verda, Vittorio, Elisa Guelpa, Vittorio Verda, Guelpa, Elisa   +3 more
core   +1 more source