Results 101 to 110 of about 2,934,371 (304)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Entropy generation during fluid flow in sharp edge wavy channels with horizontal pitch

Advances in Mechanical Engineering, 2016
In this study, the volumetric entropy generation rate is analyzed in sharp edge wavy channels. A two-dimensional steadily developing fluid flow is considered. Air is considered as the working fluid in the numerical analysis.
Haitham MS Bahaidarah
doaj   +1 more source

Teach Second Law of Thermodynamics via Analysis of Flow through Packed Beds and Consolidated Porous Media

Fluids, 2019
The second law of thermodynamics is indispensable in engineering applications. It allows us to determine if a given process is feasible or not, and if the given process is feasible, how efficient or inefficient is the process.
Rajinder Pal
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Effect of Incidence Angle on Entropy Generation in the Boundary Layers on the Blade Suction Surface in a Compressor Cascade

Entropy, 2019
The entropy generation that occurs within boundary layers over a C4 blade at a Reynolds number of 24,000 and incidence angles (i) of 0°, 2.5°, 5°, 7.5°, and 10° are investigated experimentally using a particle image velocimetry ...
Lei Shi, Hongwei Ma
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Second law efficiency and thermal entropy generation of 30:70% of glycerol + water based SiO2 nanofluids in a thermosyphon flat plate collector: Experimental and Bayesian artificial neural network algorithm

International Journal of Thermofluids
This research examines the thermal entropy generation, frictional entropy generation, entropy generation number, and energy efficiency, which were experimentally assessed for a flat plate collector functioning under thermosyphon conditions utilizing a ...
L.S. Sundar, Sérgio M.O. Tavares, Korada V Sharma, António M.B. Pereira   +3 more
doaj   +1 more source

Entropy generation analysis in an evaporative air-cooled heat exchanger

Journal of Thermal Science and Technology, 2014
In the present study, air-side entropy generation rate for an evaporative air-cooled heat exchanger has been investigated using thermodynamic second-law analysis.
Shoeib MAHJOUB, Mohammad Reza SALIMPOUR, Hossein SHOKOUHMAND, Zabihollah BAHRAMI   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A mathematical model for entropy generation in a Powell-Eyring nanofluid flow in a porous channel

Heliyon, 2019
The continuous generation of entropy leads to exergy destruction which reduces the performance of a physical system. Hence, entropy minimization becomes necessary.
Hammed Abiodun Ogunseye, Precious Sibanda   +1 more
doaj   +1 more source