Results 91 to 100 of about 3,082,804 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Generalized Entropy Generation Expressions in Gases [PDF]

Entropy, 2019
In this study, we generalize our previous methods for obtaining entropy generation in gases without the need to carry through a specific expansion method, such as the Chapman–Enskog method. The generalization, which is based on a scaling analysis, allows for the study of entropy generation in gases for any arbitrary state of the gas and consistently ...
openaire   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

On the Connections of Generalized Entropies With Shannon and Kolmogorov–Sinai Entropies [PDF]

Entropy, 2014
We consider the concept of generalized Kolmogorov–Sinai entropy, where instead of the Shannon entropy function, we consider an arbitrary concave function defined on the unit interval, vanishing in the origin. Under mild assumptions on this function, we show that this isomorphism invariant is linearly dependent on the Kolmogorov–Sinai entropy.
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Entropy Generation Analysis of Wildfire Propagation [PDF]

, 2017
Entropy generation is commonly applied to describe the evolution of irreversible processes, such as heat transfer and turbulence. These are both dominating phenomena in fire propagation.
Verda, Vittorio, Elisa Guelpa, Vittorio Verda, Guelpa, Elisa   +3 more
core   +1 more source

A study of the local entropy generation rate in a porous media burner

Archives of Mechanics, 2020
In this paper, the work and performance of the premixed methane-air porous axisymmetrical burner have firstly been simulated numerically using the CFD tools.
I. Mohammadi, J.A. Esfahani, K.C. Kim
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Teach Second Law of Thermodynamics via Analysis of Flow through Packed Beds and Consolidated Porous Media

Fluids, 2019
The second law of thermodynamics is indispensable in engineering applications. It allows us to determine if a given process is feasible or not, and if the given process is feasible, how efficient or inefficient is the process.
Rajinder Pal
doaj   +1 more source