Results 81 to 90 of about 2,934,371 (304)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Entropy-based semi-fragile watermarking of remote sensing images in the wavelet domain
, 2019 This article presents a semi-fragile image tampering detection method for multi-band images. In the proposed scheme, a mark is embedded into remote sensing images, which have multiple frequential values for each pixel, applying tree-structured vector ...
Serra Ruiz, Jordi +5 more
core +1 more source
Entropy Region and Network Information Theory [PDF]
, 2011 This dissertation takes a step toward a general framework for solving network information theory problems by studying the capacity region of networks through the entropy region.
Sormeh Shadbakht, Shadbakht, Sormeh
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
On Generalized Schürmann Entropy Estimators
Entropy, 2022 We present a new class of estimators of Shannon entropy for severely undersampled discrete distributions. It is based on a generalization of an estimator proposed by T. Schürmann, which itself is a generalization of an estimator proposed by myself.For a special set of parameters, they are completely free of bias and have a finite variance, something ...
openaire +7 more sources
A Brief Review of Generalized Entropies [PDF]
Entropy, 2018 Entropy appears in many contexts (thermodynamics, statistical mechanics, information theory, measure-preserving dynamical systems, topological dynamics, etc.) as a measure of different properties (energy that cannot produce work, disorder, uncertainty, randomness, complexity, etc.). In this review, we focus on the so-called generalized entropies, which
José M. Amigó +2 more
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Diffuser and Nozzle Design Optimization by Entropy Generation Minimization
, 2011 Diffusers and nozzles within a flow system are optimized with respect to their wall shapes for a given change in cross sections. The optimization target is a low value of the head loss coefficient K, which can be linked to the overall entropy generation ...
Heinz Herwig +3 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source