Results 121 to 130 of about 25,153,568 (292)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Entropy Generation Analysis of Hybrid Nanomaterial through Porous Space with Variable Characteristics. [PDF]

Entropy (Basel), 2021
Sadiq MA, Haider F, Hayat T.
europepmc   +1 more source

Entropy generation analysis in greenhouse environmental system

Journal of Physics: Conference Series
Abstract To minimize energy loss in a greenhouse environmental system, analyzing the entropy generation within the system is crucial. Based on the established mathematical model of the greenhouse environment, entropy generation in the greenhouse environment system is analyzed, and the irreversible energy loss in the greenhouse ...
Shujiao Tian, Yixiao Chang, Riru Zhang, Zhijuan Zhang   +3 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Entropy generation: Minimum inside and maximum outside

, 2014
Extremum of the entropy generation is evaluated for both maximum and minimum using a thermodynamic approach which is usually applied in engineering to design energy transduction systems.
Umberto Lucia, LUCIA, UMBERTO
core   +1 more source

Bioconvective Reiner-Rivlin nanofluid flow over a rotating disk with Cattaneo-Christov flow heat flux and entropy generation analysis. [PDF]

Sci Rep, 2021
Lv YP, Gul H, Ramzan M, Chung JD, Bilal M.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Maximum or minimum entropy generation for open systems?

, 2012
Entropy generation is analysed and obtained from the entropy balance for open systems, considering the lifetime of the natural real process. The Lagrangian approach is discussed in order to develop an analytical method to obtain the stationary states of ...
Lucia, Umberto
core   +1 more source

Optimization of Entropy generation on peristaltic flow of nanofluid having compliant walls by RSM: Sensitivity analysis

International Journal of Thermofluids
In this study the mathematical model of entropy generation of peristaltic flow of nanofluid is developed under the assumption of long wavelength and low Reynolds number.
Saima Muhammad, Dilawar Hussain, Munawwar Ali Abbas   +2 more
doaj   +1 more source

Numerical Study of Fin-and-Tube Heat Exchanger in Low-Pressure Environment: Air-Side Heat Transfer and Frictional Performance, Entropy Generation Analysis, and Model Development. [PDF]

Entropy (Basel), 2022
Zhang L, Wang J, Liu R, Li G, Han X, Zhang Z, Zhao J, Dai B.   +7 more
europepmc   +1 more source