Results 91 to 100 of about 54,636 (287)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Entropy generation and jet engine optimization

open access: yes, 2010
In 2009, it was shown that, with an original approach to hydrodynamic cavitation, a phenomenological model was realized in order to compute some of the physical parameters needed for the design of the most common technological applications (turbo ...
Lucia, Umberto
core  

Adaptive compressive tomography: a numerical study

open access: yes, 2019
We perform several numerical studies for our recently published adaptive compressive tomography scheme [D. Ahn et al. Phys. Rev. Lett. 122, 100404 (2019)], which significantly reduces the number of measurement settings to unambiguously reconstruct any ...
Ahn, D.   +7 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Entropic Lattice Boltzmann Method for Moving and Deforming Geometries in Three Dimensions

open access: yes, 2016
Entropic lattice Boltzmann methods have been developed to alleviate intrinsic stability issues of lattice Boltzmann models for under-resolved simulations.
Chikatamarla, S. S.   +2 more
core   +1 more source

Entropy generation minimization in parallel-plates counterflow heat exchangers

open access: yesInternational Journal of Energy Research, 2000
This paper shows that the main architectural features of a counterflow heat exchanger can be determined based on thermodynamic optimization subject to volume constraint. It is assumed that the channels are formed by parallel plates, the two fluids are ideal gases, and the flow is fully developed, laminar or turbulent. In the first part of the paper, it
Juan Carlos Ord��ez, Adrian Bejan
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

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