Results 91 to 100 of about 125,230 (316)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Entropy, 2016 Dan Rudolph showed that for an amenable group, Γ, the generic measure-preserving action of Γ on a Lebesgue space has zero entropy. Here, this is extended to nonamenable groups.
Lewis Bowen
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Approximate entropy as an indicator of non-linearity in self paced voluntary finger movement EEG [PDF]
, 2013 This study investigates the indications of non-linear dynamic structures in electroencephalogram signals. The iterative amplitude adjusted surrogate data method along with seven non-linear test statistics namely the third order autocorrelation, asymmetry
Balli, Tugce +2 more
core +1 more source
A New Entropy Measure and COPRAS Method for Spherical Fuzzy Sets
IEEE AccessOne of the best ways to handle the ambiguity and unpredictable nature of decision-making is through fuzzy logic, and one of the most recent developments in this area is the concept of spherical fuzzy sets.
Abdul Haseeb Ganie +2 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 2023 So far, most articles using the multivariate multi-scale entropy algorithm mainly use algorithms to analyze the multivariable signal complexity without clearly describing what characteristics of signals these algorithms measure and what factors affect ...
Xiuru Zhang +6 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 2020 An improved permutation entropy (PE) algorithm named coded permutation entropy (CPE) is proposed in this paper to optimize the problems existing in PE based on the secondary partitioning. The principle of CPE algorithm is given, and the performance of it
Huan Kang +2 more
core +1 more source