Results 71 to 80 of about 392,964 (284)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combinatorial Entropy for Distinguishable Entities in Indistinguishable States

, 2007
The combinatorial basis of entropy by Boltzmann can be written $H= {N}^{-1} \ln \mathbb{W}$, where $H$ is the dimensionless entropy of a system, per unit entity, $N$ is the number of entities and $\mathbb{W}$ is the number of ways in which a given ...
Andrea Rapisarda, Constantino Tsallis, Hans Herrmann, Piero Quarati, Robert K. Niven, Sumiyoshi Abe   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

E-BOOT: Preventing Boot-Time Entropy Starvation in Cloud Systems

IEEE Access, 2020
Due to the impracticability of generating true randomness by running deterministic algorithms in computers, boot-loaders and operating systems undergo the lack of enough supplies of entropy at boot-time.
Fernando Vano-Garcia, Hector Marco-Gisbert   +1 more
doaj   +1 more source

Extrapolation estimates for entropy numbers

Journal of Functional Analysis, 2012
Let \(\Theta \subseteq [0,1]\) be an interval, let \(Y_0,Y_1\) be Banach spaces and let \(\{ Y_\eta \}_{\eta \in \Theta}\) be an ordered family of Banach spaces, i.e., \(Y_0 \hookrightarrow Y_\theta \hookrightarrow Y_\eta \hookrightarrow Y_1\) for any \(\theta \leq \eta\) with \(\theta, \eta \in \Theta\).
Cobos, Fernando, Kühn, Thomas
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Entropy numbers of spheres in Banach and quasi-Banach spaces

, 2015
We prove sharp upper bounds on the entropy numbers $e_k(S^{d-1}_p,\ell_q^d)$ of the $p$-sphere in $\ell_q^d$ in the case $k \geq d$ and $0< p \leq q \leq \infty$. In particular, we close a gap left open in recent work of the second author, T. Ullrich and
Hinrichs, Aicke, Mayer, Sebastian
core   +1 more source

Quantum lower bounds by entropy numbers

Journal of Complexity, 2007
We use entropy numbers in combination with the polynomial method to derive a new general lower bound for the n-th minimal error in the quantum setting of information-based complexity. As an application, we improve some lower bounds on quantum approximation of embeddings between finite dimensional L_p spaces and of Sobolev embeddings.
openaire   +3 more sources

Pseudorandom numbers and entropy conditions

Journal of Complexity, 2007
The authors investigate measures of pseudorandomness of finite sequences \((x_n)\) of real numbers. They extend the well-distribution measure introduced by \textit{C. Mauduit} and \textit{A. Sárközy} [Acta Arith. 82, No. 4, 365--377 (1997; Zbl 0886.11048)], which analyzes the behavior of a sequence \((x_n)\) along arithmetic progressions \((x_{ak+b})\),
Berkes, István, Philipp, Walter, Tichy, Robert F.   +2 more
openaire   +1 more source