Results 251 to 260 of about 307,376 (353)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

V-SYNTHES2-the next generation tool for structure-based virtual screening of giga-scale chemical spaces. [PDF]

NPJ Drug Discov
Nazarova AL, Sadybekov AV, Sadybekov AA, Protopopov M, Radchenko DS, Moroz YS, Tarkhanova OO, Katritch V.   +7 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Survivors' Responses to an Online Intervention to Promote Discussions of Cancer Genetic Risk with Blood Relatives.

Public Health Genomics
Zhao J, McBride CM, Shepperd JA, An W, Escoffery C, Ward K, Pentz RD, Guan Y.   +7 more
europepmc   +1 more source

Reliability of the L3 Transverse Process as a Landmark for Lumbar Spine Enumeration Across Different Vertebral Segmentation Patterns: A Retrospective CT Study. [PDF]

Diagnostics (Basel)
Jankowski J, Maślanek N, Glin M, Jasiewicz M, Pawełczyk A, Polguj M, Radek M.   +6 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Current Status and Future Trends in <i>Campylobacter</i> Detection and Quantification Across the Food Production Continuum. [PDF]

Pathogens
Bommineni V, Edison LK, Kariyawasam S.
europepmc   +1 more source

The Enumeration of Blood Platelets [PDF]

Journal of Clinical Pathology, 1948
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Serology Confirms Near-Absence of Malaria Transmission in Timor-Leste. [PDF]

Am J Trop Med Hyg
Amaral EF, Byrne I, Brazal Monzo H, Sarmento R, Do Rosario De Fatima Mota M, Rangel G, Tanesi M, Salles de Sousa A, Martins N, Oakley T, Alves L, Yan J, Arkell P, Francis JR, Drakeley C.   +14 more
europepmc   +1 more source