Results 41 to 50 of about 14,572 (203)

Microglial reactivity attenuates ptau231‐related amyloid accumulation in preclinical Alzheimer’s disease [PDF]

Alzheimers Dement
Abstract Background Recent studies indicate that soluble tau phosphorylated at threonine 231 (p‐tau231) rises most prominently in the earliest preclinical stages of Alzheimer's disease (AD), preceding overt amyloid‐beta (Aβ) PET positivity. Elevated p‐tau231 levels may promote emerging Aβ deposition, but the biological mechanisms linking early tau ...
Pelkmans W, Shekari M, Escalante A, Kollmorgen G, Quijano‐Rubio C, Blennow K, Zetterberg H, Gispert J, Suárez‐Calvet M, Salvadó G.   +9 more
europepmc   +3 more sources

Efecto terapéutico de la biomodulina T homeopática con pacientes portadores de enfermedad pulmonar obstructiva crónica

Revista Habanera de Ciencias Médicas, 2011
Se realizó un Ensayo Clínico Controlado, fase II, aleatorizado y abierto en el Centro de Investigaciones sobre Longevidad, Envejecimiento y Salud, durante el período comprendido entre el año 2008 y 2009, con el objetivo de evaluar el efecto terapéutico ...
Marlene García Orihuela, René Suárez Martínez, Inés Castro González, Diarislay Santiago Paz, Ismary Alfonso Orta   +4 more
doaj  

Differential contribution of T‐type voltage‐gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits

Experimental Physiology, EarlyView.
Abstract figure T‐type VGCCs contribute to the contraction of the rabbit aorta and modulate both contraction and vasodilation in the rabbit renal artery. α1, alpha 1 adrenergic receptor; ATR, angiotensin II receptor; Ang II, angiotensin II; CaM, calmodulin; Cav3, T‐type voltage‐gated Ca2⁺ channels; cGMP, cyclic guanidine monophosphate; EC, endothelial ...
Andrea Suarez, Sol Guerra‐Ojeda, Manuel Zarzoso, Marta Serna‐García, Jose M. Vila, Eva Serna, Maria D. Mauricio   +6 more
wiley   +1 more source

Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION It is unknown if neurodegeneration trajectories differ between Down syndrome (DS) and autosomal dominant Alzheimer's disease (ADAD), both of which are genetic forms of Alzheimer's disease (AD). METHODS We compared brain volumes in DS, ADAD, and unaffected family members serving as controls.
James T. Kennedy, Julie K. Wisch, Anna H. Boerwinkle, Peter R. Millar, Nicole S. McKay, Adam M. Brickman, Jasmeer P. Chhatwal, Patricio Chrem Mendez, Bradley T. Christian, Anne Cohen, Carlos Cruchaga, Alisha Daniels, Shaney Flores, Benjamin L. Handen, Sigan L. Hartley, Elizabeth Head, Laura Ibanez, Sharon J. Krisnsky‐McHale, Christian la Fougere, Florence Lai, Charles M. Laymon, Joseph H. Lee, Jae‐Hong Lee, Johannes Levin, Jorge Llibre‐Guerra, David F. Aguillon, Ira T. Lott, Mark Mapstone, Eric McDade, John Morris, Sid E. O'Bryant, Julie C. Price, Michael S. Rafii, Jee Hoon Roh, H. Diana Rosas, Nicole Schupf, Charlene Supnet‐Bell, Chengjie Xiong, Shahid Zaman, Tammie L. S. Benzinger, Brian A. Gordon, Beau M. Ances, the Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network   +43 more
wiley   +1 more source

Cognitive Reserve and Its Relationship With Memory Changes: An Analysis of the Survey of Health, Aging, and Retirement in Europe (SHARE)

International Journal of Geriatric Psychiatry, Volume 41, Issue 1, January 2026.
ABSTRACT Objectives To examine the longitudinal association between cognitive reserve (CR)‐related proxies and episodic memory in older adults, and to explore the role of sociodemographic and clinical risk factors. Methods Data were drawn from 2279 participants of the Survey of Health, Aging and Retirement in Europe (SHARE), with baseline in wave 5 ...
Juan C. Melendez, Luis Carlos Venegas, Claire P. de la Fuente   +2 more
wiley   +1 more source

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Validation status of cognitive digital assessments by the FDA BEST framework and context of use in preclinical AD studies: A systematic review

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract Digital cognitive assessments have rapidly expanded in Alzheimer's disease (AD) research, offering a sensitive, scalable, and cost‐effective alternative to traditional neuropsychological tests. This systematic review examines the validation and utility of digital cognitive assessments in cognitively normal (CN) individuals and explores their ...
Clàudia Porta‐Mas, Oriol Grau‐Rivera, Juan Domingo Gispert, Gemma Salvadó Blasco, Gonzalo Sánchez‐Benavides   +4 more
wiley   +1 more source

Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Functional impairment across degenerative dementias remains understudied in Latin American contexts. We aimed to assess total and item‐level functional performance, determine specific instrumental activities, and identify differences in functional profiles between groups.
Nilton Custodio, Gregory Brown, Belén Custodio, Rosa Montesinos, Milagros Nuñez‐Huanca, Pamela Bartolo, Zadith Yauri, Katherine Agüero, Graciet Verastegui, Agustin Ibañez   +9 more
wiley   +1 more source

Envejecimiento activo en Latinoamérica: Revisión narrativa de la literatura

Horizonte Sanitario
Objetivo: Presentar una revisión narrativa de la literatura sobre el envejecimiento activo en Latinoamérica. Material y métodos: La búsqueda de artículos se efectuó en las bases de datos EBSCO Host, Web of Science, SciELO, Redalyc, Dialnet plus, JSTOR,
María Alejandra Favela Ocaño, María del Carmen Castro Vásquez   +1 more
doaj   +1 more source

Envejecimiento normal

Revista Estomatología, 1993
El envejecimiento normal o fisiológico está más cerca de la salud que de la enfermedad; el envejecimiento como proceso natural no es deteriorante y ésta es una idea que se debe resaltar. El envejecimiento biológico comprende los cambios orgánicos estructurales y.funcionales en los seres vivos y en el ser humano a nivel macroscópico y microscópico.
openaire   +1 more source