Results 151 to 160 of about 4,160,774 (255)

The Transmembrane Envelope Protein of Porcine Endogenous Retroviruses Modulates Cytokine Release and Gene Expression in Human Immune Cells. [PDF]

Int J Mol Sci
Ban J, Schienke A, Quotschalla M, Brinkmann A, Krabben L, Rausch S, Kaufer BB, Schwinzer R, Noyan F, Denner J.   +9 more
europepmc   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

Darunavir and Fosamprenavir Inhibit Zika Virus Replication via Dual Targeting of the Envelope Protein and NS2B-NS3 Protease. [PDF]

J Med Virol
Kan JY, Su HC, Lai HC, Lin YF, Chiu SW, Wu PC, Hsueh PR, Lu CH, Lin CW.   +8 more
europepmc   +1 more source

A Fluorogenic Cysteine‐Tetrapeptide Tagging Strategy for Nonperturbative Protein Labeling and Protein–Ligand Interaction Tracking

Advanced Science, EarlyView.
A compact Phe‐Cys‐Pro‐Phe (FCPF) tag and an environment‐sensitive SBD‐Cl‐derived probe form a sequence‐selective fluorogenic pair for wash‐free live‐cell protein imaging. This minimally perturbing chemistry allows flexible insertion at termini or loops, produces strong fluorescence upon local microenvironment confinement, supports FRET‐assisted ...
Xiao Wang, Xingcan Pan, Yongling Ying, Ziqian Bai, Jingming Zhang, Zhuang Shao, Jialiang Qian, Hongwei Li, Ning Zhang, Fan Yang, Yuan Liu, Xing Yang   +11 more
wiley   +1 more source

Full-length SARS-CoV-2 envelope protein adopts an interfacial topology in lipid bilayers. [PDF]

Biochim Biophys Acta Biomembr
Morris AK, Wardrip L, Sahu ID, Lorigan GA.   +3 more
europepmc   +1 more source

Envelope Addressed to Clara MacNaughton from Clara B. Colby

, 1905
Envelope addressed to Clara MacNaughton from Clara B. Colby; envelope redirected from Washington, D.C., to Grand Rapids, Mich.Incoming Correspondence to Dr.
Colby, Clara Dorothy Bewick, 1846-1916, MacNaughton, Clara   +1 more
core  

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +2 more sources

HBV Envelope Protein-Bearing Vesicles Show Preferential Uptake in Hepatocyte-Derived Cells. [PDF]

Int J Mol Sci
Takayama E, Enomoto M, Nagae M, Tomoda M, Miyazumi Y, Iwaisako Y, Shirasawa R, Suzuki Y, Nakano T, Ueda K, Fujimuro M.   +10 more
europepmc   +1 more source

Interface‐Confined Cavitation at an MXene/TiO2 Schottky Heterointerface for Non‐Thermal Juice Preservation

Advanced Science, EarlyView.
This work establishes an MXene/TiO2 Schottky heterointerface for non‐thermal sonocatalysis. Interface‐confined cavitation and dynamic Ti3+/V₀ shuttles drive charge transport and reactive oxygen species (ROS) generation. The platform achieves 3‐log pathogen reduction while retaining heat‐labile nutrients in complex food matrices, redefining sonocatalyst
Xiaoge Wu, Yunxiao Zhu, Nan Qin, Zhaoli Zhang, Qi Zhang, Yang Tao   +5 more
wiley   +1 more source