Results 51 to 60 of about 521,167 (261)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2

Journal of Virology
Porcine reproductive and respiratory syndrome viruses (PRRSVs) are significant pathogens that affect the global swine industry. Its virions consist of a central core composed of nucleocapsid (N) protein, surrounded by multiple distinct viral envelope ...
Yuan-Zhe Bai, Shujie Wang, Yue Sun, Yong-Gang Liu, Hong-Liang Zhang, Qian Wang, Rui Huang, Cui-Hong Rao, Shi-Jia Xu, Zhi-Jun Tian, Tong-Qing An, Xue-Hui Cai, Yan-Dong Tang   +12 more
doaj   +1 more source

Phosphorylation of chloroplast ribulose bisphosphate carboxylase/oxygenase small subunit by an envelope-bound protein kinase in situ [PDF]

, 1983
A new protein kinase of the cAMP independent type was found to be bound to the outer envelope membrane of spinach chloroplasts. While stimulated by Mg2+ and inhibited by ADP, the enzyme showed no response to conventional protein substrates and was ...
Buchanan, Bob B., Soll, Jürgen
core  

Expression in Escherichia coli of a cloned DNA sequence encoding the pre-S2 region of hepatitis B virus [PDF]

, 1985
A DNA sequence encoding the entire pre-S2 region (amino acids 120-174; serotype ayw) of human hepatitis B virus envelope protein has been inserted into the lacZ gene of the plasmid pSKS105 yielding a recombinant, pWS3.
Acs, George, Christman, Judith K., Kent, Stephen B. H., Neurath, A. Robert, Offensperger, Wolf, Price, Peter, Strick, Nathan, Wahl, Silke   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

In-silico Antigenicity Determination and Clustering of Dengue Virus Serotypes

Frontiers in Genetics, 2018
Emerging or re-emerging dengue virus (DENV) causes dengue fever epidemics globally. Current DENV serotypes are defined based on genetic clustering, while discrepancies are frequently observed between the genetic clustering and the antigenicity ...
Jingxuan Qiu, Yuxuan Shang, Zhiliang Ji, Tianyi Qiu   +3 more
doaj   +1 more source

Transcription of the Envelope Protein by 1-L Protein–RNA Recognition Code Leads to Genes/Proteins That Are Relevant to the SARS-CoV-2 Life Cycle and Pathogenesis

Current Issues in Molecular Biology, 2022
The theoretical protein–RNA recognition code was used in this study to research the compatibility of the SARS-CoV-2 envelope protein (E) with mRNAs in the human transcriptome.
Jozef Nahalka
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Adjuvant-Mediated Epitope Specificity and Enhanced Neutralizing Activity of Antibodies Targeting Dengue Virus Envelope Protein

Frontiers in Immunology, 2017
The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies.
Denicar Lina Nascimento Fabris Maeda, Milene Tavares Batista, Milene Tavares Batista, Lennon Ramos Pereira, Mariana de Jesus Cintra, Jaime Henrique Amorim, Camila Mathias-Santos, Sara Araújo Pereira, Silvia Beatriz Boscardin, Sandriana dos Ramos Silva, Eliana L. Faquim-Mauro, Vanessa Barbosa Silveira, Danielle Bruna Leal Oliveira, Stephen Albert Johnston, Luís Carlos de Souza Ferreira, Juliana Falcão Rodrigues   +15 more
doaj   +1 more source

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins

Frontiers in Microbiology, 2022
The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains, which is identical to the PBM of SARS-CoV.
Yanlei Zhu, Flavio Alvarez, Nicolas Wolff, Ariel Mechaly, Sébastien Brûlé, Benoit Neitthoffer, Sandrine Etienne-Manneville, Ahmed Haouz, Batiste Boëda, Célia Caillet-Saguy   +9 more
doaj   +1 more source